Association of Expression of Selenoprotein P in mRNA and Protein Levels with Metabolic Syndrome in Subjects with Cardiovascular Disease: Results of Selenegene Study
ConclusionsIn conclusion, we demonstrated a significant decrease in circulating SeP levels according to MetS status in patients with documented cardiovascular disease. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 31, 2016 Category: Genetics & Stem Cells Authors: Mojgan Gharipour, Masoumeh Sadeghi, Mansour Salehi, Mehrdad Behmanesh, Elham Khosravi, Minoo Dianatkhah, Rouzbeh Razavi, Amin Gharipour Tags: RESEARCH ARTICLE Source Type: research
mRNA destabilization improves glycemic responsiveness of transcriptionally regulated hepatic insulin gene therapy in vitro and in vivo.
ConclusionsData suggest that combining transcriptional and post‐transcriptional regulatory strategies may reduce undesirable glycemic excursion in models of HIGT. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 31, 2016 Category: Genetics & Stem Cells Authors: Peter M. Thul é, Yulin Lin, Dingwu Jia, Darin E. Olson, Shiue‐Cheng Tang, Athanassios Sambanis Tags: RESEARCH ARTICLE Source Type: research
Issue Information
No abstract is available for this article. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 28, 2016 Category: Genetics & Stem Cells Tags: ISSUE INFORMATION Source Type: research
ZNF208 polymorphisms associate with ischemic stroke in southern Chinese Han population
ConclusionThe results indicate a potential association between ZNF208 variants and ischemic stroke risk in southern Chinese Han population. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 8, 2016 Category: Genetics & Stem Cells Authors: Jianzhong Yu, Feng Zhou, Dong Luo, Nianzhen Wang, Chong Zhang, Tianbo Jin, Xiongfei Liang, Dan Yu Tags: RESEARCH ARTICLE Source Type: research
Posterior tibial tendinopathy associated with Matrix Metalloproteinase 13 promoter genotype and haplotype
ConclusionsIn conclusions these findings indicate that MMP‐13 g.‐77 A > G (rs2252070) polymorphism isolated and its haplotypes MMP‐1 g.‐519 A > G (rs1144393), MMP‐1 g.‐1607 G > GG (rs1799750) and MMP‐8 g.‐799 C > T (rs11225395) may contribute to PTT dysfunction. This article is protected by copyright. All rights reserved. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - November 24, 2016 Category: Genetics & Stem Cells Authors: Francielle Bo çon Araujo Munhoz, José Eduardo Baroneza, Alexandre Godoy‐Santos, Túlio Diniz Fernandes, Filipe Polese Branco, Lupe Furtado Alle, Ricardo Lehtonen Souza, Maria Cristina Leme Godoy Santos Tags: REVIEW ARTICLE Source Type: research
Gene Therapy for Achromatopsia
ConclusionDuring the last years, huge progress has been made towards bringing a curative treatment for ACHM into clinics. First clinical trials are ongoing or will be launched soon and are expected to contribute important data on the safety and efficacy of ACHM gene supplementation therapy. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - October 31, 2016 Category: Genetics & Stem Cells Authors: Stylianos Michalakis, Christian Sch ön, Elvir Becirovic, Martin Biel Tags: REVIEW ARTICLE Source Type: research
Humanized Chondroitinase ABC Sensitizes Glioblastoma Cells to Temozolomide
ConclusionThese data reveal that OV‐ChaseM enhances glioma cell viral susceptibility and sensitivity to TMZ. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - October 31, 2016 Category: Genetics & Stem Cells Authors: Alena Cristina Jaime ‐Ramirez, Nina Dmitrieva, Ji Young Yoo, Yeshavanth Banasavadi‐Siddegowda, Jianying Zhang, Theresa Relation, Chelsea Bolyard‐Blessing, Jeffrey Wojton, Balveen Kaur Tags: RESEARCH ARTICLE Source Type: research
Association of the HNF1A polymorphisms and serum lipid traits, the risk of coronary artery disease and ischemic stroke
ConclusionsThese findings suggest that the HNF1A polymorphisms may be the genetic risk factors for CAD and IS. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - October 31, 2016 Category: Genetics & Stem Cells Authors: Yi ‐Jiang Zhou, Rui‐Xing Yin, Shao‐Cai Hong, Qian Yang, Xiao‐Li Cao, Wu‐Xian Chen Tags: RESEARCH ARTICLE Source Type: research
Genetic disruption of the KLF1 gene to overexpress the γ‐globin gene using the CRISPR/Cas9 system
ConclusionsThe findings obtained in the present study support the induction of an indel mutation in the KLF1 gene leading to a null allele. As a result, the effect of KLF1 on the expression of BCL11A is decreased and its inhibitory effect on γ‐globin gene expression is removed. Application of CRISPR technology to induce an indel in the KLF1 gene in adult erythroid progenitors may provide a method for activating fetal hemoglobin expression in individuals with β‐thalassemia or sickle cell disease. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - October 29, 2016 Category: Genetics & Stem Cells Authors: Laleh Shariati, Hossein Khanahmad, Mansoor Salehi, Zahra Hejazi, Ilnaz Rahimmanesh, Mohammad Amin Tabatabaiefar, Mohammad Hossein Modarressi Tags: RESEARCH ARTICLE Source Type: research
Association between LEKR1 ‐CCNL1 and IGSF21‐KLHDC7A gene polymorphisms and diabetic retinopathy of type 2 diabetes mellitus in the Chinese Han population
ConclusionsOur results suggest that LEKR1‐CCNL1 and IGSF21‐KLHDC7A influence the development of DR. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - October 29, 2016 Category: Genetics & Stem Cells Authors: Xiaohui Lin, Jihong Wang, Lixia Yun, Shuhong Jiang, Langen Li, Xiaohai Chen, Zhen Li, Qiang Lu, Yihui Zhang, Xiaocheng Ma Tags: RESEARCH ARTICLE Source Type: research
Issue Information
No abstract is available for this article. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - October 29, 2016 Category: Genetics & Stem Cells Tags: Issue Information Source Type: research
An in vivo transfection system for inducible gene expression and gene silencing in murine hepatocytes
ConclusionsOur vector system combines Cre‐lox mediated gene mutation with inducible gene expression or gene knock‐down, respectively. It provides the opportunity for rapid and specific modification of hepatocyte gene expression and can be a useful tool for genetic screening approaches and analysis of target genes specifically in genetically engineered mouse models. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - September 30, 2016 Category: Genetics & Stem Cells Authors: Eric K Hubner, Christian Lechler, Birgit Kohnke ‐Ertel, Anne‐Flore Zmoos, Julien Sage, Roland M Schmid, Ursula Ehmer Tags: RESEARCH ARTICLE Source Type: research
Integration of expression quantitative trait loci and pleiotropy identifies novel psoriasis susceptibility gene, PTPN1
ConclusionsThe results highlight the eQTL enrichment and pleiotropy in psoriasis and schizophrenia, suggest a possible key role of the PTPN1 gene in the etiology of psoriasis. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - September 30, 2016 Category: Genetics & Stem Cells Authors: Xianyong Yin, Yuan Lin, Changbing Shen, Ling Wang, Xianbo Zuo, Xiaodong Zheng, Sen Yang, Jianjun Liu, Kirk C. Wilhelmsen, Xuejun Zhang Tags: RESEARCH ARTICLE Source Type: research
MicroRNA ‐4656 is a prognostic factor and tumor suppressor in human pancreatic through downstream tareget of TrkA
ConclusionMiR‐4656 is lowly expressed and a potential biomarker in PC. Overexpressing miR‐4656 has tumor suppressive effects on PC development both in vitro and in vivo, likely through its downstream target of TrkA gene. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - September 30, 2016 Category: Genetics & Stem Cells Authors: Xianglong Tan, Jinyong Lv, Guodong Zhao, Zhiming Zhao, Chenggang Li, Yong Xu, Minggen Hu Tags: RESEARCH ARTICLE Source Type: research
Genomic Data Integration in Chronic Lymphocytic Leukemia
We described a novel method to elucidate how these mutations affect gene expression by finding small‐scale signatures to predict the IgVH, NOTCH1 and SF3B1 mutations. We subsequently defined the biological pathways and correlation networks that are involved in the disease development with the potential goal of identifying new druggable targets.
MethodsWe modeled a microarray data set consisting of 48807 probes derived from 163 samples. Using Fisher's ratio and Fold change combined with feature elimination allowed us to identify the minimum number of genes with the highest predictive mutation power and subsequently applie...
Source: The Journal of Gene Medicine - September 30, 2016 Category: Genetics & Stem Cells Authors: Juan Luis Fern ández‐Martínez, Enrique J. deAndrés‐Galiana, Stephen T. Sonis Tags: RESEARCH ARTICLE Source Type: research
