An in vivo transfection system for inducible gene expression and gene silencing in murine hepatocytes

ConclusionsOur vector system combines Cre‐lox mediated gene mutation with inducible gene expression or gene knock‐down, respectively. It provides the opportunity for rapid and specific modification of hepatocyte gene expression and can be a useful tool for genetic screening approaches and analysis of target genes specifically in genetically engineered mouse models.

Source: The Journal of Gene Medicine - September 30, 2016 Category: Genetics & Stem Cells Authors: Eric K Hubner, Christian Lechler, Birgit Kohnke ‐Ertel, Anne‐Flore Zmoos, Julien Sage, Roland M Schmid, Ursula Ehmer Tags: RESEARCH ARTICLE Source Type: research