Association between LEKR1 ‐CCNL1, IGSF21‐KLHDC7A gene polymorphism and diabetic retinopathy of type 2 diabetes mellitus in Chinese Han population
ConclusionsOur results suggest that LEKR1‐CCNL1 and IGSF21‐KLHDC7A influence the development of DR. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 31, 2016 Category: Genetics & Stem Cells Authors: Xiaohui Lin, Jihong Wang, Lixia Yun, Shuhong Jiang, Langen Li, Xiaohai Chen, Zhen Li, Qiang Lu, Yihui Zhang, Xiaocheng Ma Tags: RESEARCH ARTICLE Source Type: research
A kidney injury molecule ‐1 (Kim‐1) gene reporter in a mouse artificial chromosome: the responsiveness to cisplatin toxicity in immortalized mouse kidney S3 cells
ConclusionsWe report the feasibility of measuring in vitro cisplatin nephrotoxicity using a Kim‐1 reporter gene in S3 cells. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 31, 2016 Category: Genetics & Stem Cells Authors: Kenji Kokura, Yasushi Kuromi, Takeshi Endo, Naohiko Anzai, Yasuhiro Kazuki, Mitsuo Oshimura, Tetsuya Ohbayashi Tags: Research Article Source Type: research
Promoter Optimisation of Lentiviral Vectors for Efficient Insulin Gene Expression in Canine Mesenchymal Stromal Cells: Potential Surrogate Beta Cells
ConclusionOur results suggest that optimised lentiviral transduction of the insulin gene into primary canine MSCs renders these cells capable of secreting insulin both short‐ and long‐term, in sufficient quantities in vitro to support their potential use in insulin gene therapy. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 31, 2016 Category: Genetics & Stem Cells Authors: Pratigya Gautam, Robert D. Foale, Asha Recino, Jing Zhao, Shu Uin Gan, Maja Wallberg, Roy Calne, Andrew M. L. Lever Tags: Research Article Source Type: research
Adeno ‐associated virus‐mediated colonic secretory expression of HMGB1 A box attenuates experimental colitis in mice
ConclusionsIntracolonic application of AAV‐HMGB1 A box is effective in alleviating murine colitis and has therapeutic potential in human IBDs. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 31, 2016 Category: Genetics & Stem Cells Authors: Xiaoyan Zheng, Yifei Lv, Shuang Li, Qiannan Zhang, Xueting Zhang, Zhiming Hao Tags: RESEARCH ARTICLE Source Type: research
MicroRNA ‐144 regulates cancer cell proliferation and cell‐cycle transition in acute lymphoblastic leukemia through the interaction of FMN2
ConclusionMiR‐144 is functioning as a tumor suppressor in ALL, very likely through the inverse regulation of its target gene FMN2. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 31, 2016 Category: Genetics & Stem Cells Authors: Jie Jin, Yu Wang, Yang Xu, Xu Zhou, Yu Liu, Xiang Li, Jin Wang Tags: RESEARCH ARTICLE Source Type: research
Genetic variation of MMP ‐2(‐735 C > T) and MMP‐9(‐1562 C > T) gene in risk of development of HAND and severity of HAND
ConclusionIndividuals with MMP‐2 ‐735CT genotype, ‐735T allele and combined genotype MMP‐2 ‐735TT + MMP‐9 ‐1562CC enhanced the risk to develop HAND. Whereas MMP‐2 ‐735 CT genotype and ‐735 T allele and combined genotype of MMP‐2‐735TT + MMP‐9‐1562CC suggested protection from developing severe HAND. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 31, 2016 Category: Genetics & Stem Cells Authors: HariOm Singh, Shruti D Marathe, Vijay Nema, Manisha V Ghate, Raman R. Gangakhedkar Tags: RESEARCH ARTICLE Source Type: research
The neuropilin ‐1 receptor mediates enhanced tumor delivery of H2K polyplexes
ConclusionsCombining an endosomolytic peptide, H3K, with H2K polyplexes as a carrier further enhanced transfection in vivo. Moreover, the widespread distribution of H2K polyplexes is mediated by NRP‐1, suggesting that transcytosis of these polyplexes through the tumor endothelium may lead to efficient transfection. Copyright © 2016 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 4, 2016 Category: Genetics & Stem Cells Authors: Qixin Leng, A. James Mixson Tags: Research Article Source Type: research
Intramyocardial injection of SERCA2a ‐expressing lentivirus improves myocardial function in doxorubicin‐induced heart failure
ConclusionsSERCA2a gene transfer significantly improves left ventricle function and dimensions in doxorubicin‐induced cardiomyopathy, thus making LV‐SERCA2a gene transfer an attractive treatment modality for doxorubicin‐induced heart failure. Copyright © 2016 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 4, 2016 Category: Genetics & Stem Cells Authors: Minttu Mattila, Juha Koskenvuo, Mirva S öderström, Kim Eerola, Mikko Savontaus Tags: Research Article Source Type: research
Sendai viroplexes for epidermal growth factor receptor ‐directed delivery of interleukin‐12 and salmosin genes to cancer cells
ConclusionsThe results of the present study suggest that anti‐EGFR viroplexes can be utilized as an effective strategy for tumor‐directed gene delivery. Copyright © 2016 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 4, 2016 Category: Genetics & Stem Cells Authors: Jung Seok Kim, Min Woo Kim, Hwa Yeon Jeong, Seong Jae Kang, Sang Il Park, Yeon Kyung Lee, Hong Sung Kim, Keun Sik Kim, Yong Serk Park Tags: Research Article Source Type: research
Adenovirus ‐mediated artificial microRNA against human fibrinogen like protein 2 inhibits hepatocellular carcinoma growth
ConclusionsHFGL2 might be a potential target for controlling angiogenesis in HCC and hfgl2 gene silencing via miRNA may be an alternative strategy for the management of HCC. Copyright © 2016 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 4, 2016 Category: Genetics & Stem Cells Authors: Ming Wang, Junhui Liu, Dong Xi, Xiaoping Luo, Qin Ning Tags: Research Article Source Type: research
Cancer ‐specific promoters for expression‐targeted gene therapy: ran, brms1 and mcm5
ConclusionsThe ran, brms1, and mcm5 promoters have the specificity and strength needed for cancer‐specific expression‐targeted gene therapy. pran in particular produced exciting results when coupled with a version of the caspase 3 exon to treat bladder cancer. Copyright © 2016 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 4, 2016 Category: Genetics & Stem Cells Authors: Xuguang Chen, Jacqueline E. Scapa, David X. Liu, W T. Godbey Tags: Research Article Source Type: research
Sendai viroplexes for epidermal growth factor receptor‐directed delivery of interleukin‐12 and salmosin genes to cancer cells
ConclusionsThe results of the present study suggest that anti‐EGFR viroplexes can be utilized as an effective strategy for tumor‐directed gene delivery. Copyright © 2016 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 4, 2016 Category: Genetics & Stem Cells Authors: Jung Seok Kim, Min Woo Kim, Hwa Yeon Jeong, Seong Jae Kang, Sang Il Park, Yeon Kyung Lee, Hong Sung Kim, Keun Sik Kim, Yong Serk Park Tags: Research Article Source Type: research
Adenovirus‐mediated artificial microRNA against human fibrinogen like protein 2 inhibits hepatocellular carcinoma growth
ConclusionsHFGL2 might be a potential target for controlling angiogenesis in HCC and hfgl2 gene silencing via miRNA may be an alternative strategy for the management of HCC. Copyright © 2016 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 4, 2016 Category: Genetics & Stem Cells Authors: Ming Wang, Junhui Liu, Dong Xi, Xiaoping Luo, Qin Ning Tags: Research Article Source Type: research
Cancer‐specific promoters for expression‐targeted gene therapy: ran, brms1 and mcm5
ConclusionsThe ran, brms1, and mcm5 promoters have the specificity and strength needed for cancer‐specific expression‐targeted gene therapy. pran in particular produced exciting results when coupled with a version of the caspase 3 exon to treat bladder cancer. Copyright © 2016 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 4, 2016 Category: Genetics & Stem Cells Authors: Xuguang Chen, Jacqueline E. Scapa, David X. Liu, W T. Godbey Tags: Research Article Source Type: research
Issue Information
No abstract is available for this article. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - July 4, 2016 Category: Genetics & Stem Cells Tags: Issue Information Source Type: research
