The neuropilin ‐1 receptor mediates enhanced tumor delivery of H2K polyplexes

ConclusionsCombining an endosomolytic peptide, H3K, with H2K polyplexes as a carrier further enhanced transfection in vivo. Moreover, the widespread distribution of H2K polyplexes is mediated by NRP‐1, suggesting that transcytosis of these polyplexes through the tumor endothelium may lead to efficient transfection. Copyright © 2016 John Wiley & Sons, Ltd.

Source: The Journal of Gene Medicine - July 4, 2016 Category: Genetics & Stem Cells Authors: Qixin Leng, A. James Mixson Tags: Research Article Source Type: research