Issue Information
No abstract is available for this article. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - May 23, 2017 Category: Genetics & Stem Cells Tags: ISSUE INFORMATION Source Type: research
Association of incretins receptors genetic polymorphisms with type 2 Diabetes Mellitus in Egyptian patients
Conclusionwe revealed for the first time an association between GIPR rs2302382 polymorphism with T2DM in Egyptians. Yet, there was no significant association of GIPR rs1800437 or GLP‐1R rs367543060 with T2DM risk. The haplotype A (rs2302382) C (rs1800437) was associated with increased risk of T2DM. Furthermore, there was a significant increase of GIP and a significant decrease of GLP‐1 levels when compared the diabetic patients to the controls. An important finding was that there was a relation between both GIPRrs2302382 and rs1800437 variants with their cognate ligand levels. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - May 1, 2017 Category: Genetics & Stem Cells Authors: Sally M. Shalaby, Haidy E. Zidan, AmiraShokry, Jehan Saeed, Rehab H. El ‐Sokkary Tags: RESEARCH ARTICLE Source Type: research
Susceptibility to HIV ‐1 infection is influenced by Toll like Receptor‐2 (‐196 to ‐174) Polymorphism in North Indian Population
ConclusionThis study reports for the first time that TLR2 ‐196 to ‐174 Ins/Del polymorphism is a risk factor for HIV‐1 transmission in HIV‐1 infected North Indian individuals. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - May 1, 2017 Category: Genetics & Stem Cells Authors: Sanjukta Vidyant, Animesh Chatterjee, Vikas Agarwal, Tapan N. Dhole Tags: RESEARCH ARTICLE Source Type: research
Multivalent methionine ‐functionalized biocompatible block copolymers for targeted siRNA delivery and subsequent reversal effect on adriamycin resistance in human breast cancer cell line MCF‐7/ADR
ConclusionsThe synthesized polymer vector can deliver siRNA molecules into tumor cells and then reverse drug resistance by down regulation of P‐glycoprotein (P‐gp) mRNA expression. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - May 1, 2017 Category: Genetics & Stem Cells Authors: Yang Wu, Wei Zhang, Tinghan Li, Rong Ma, Dan Chen, Junying Zhang, Jianzhong Wu, Jinhai Tang Tags: RESEARCH ARTICLE Source Type: research
In vitro and in vivo gene delivery using chitosan/hyaluronic acid nanoparticles: Influences of molecular mass of hyaluronic acid and lyophilization on the transfection efficiency
ConclusionsThe coating of pDNA/chitosan complexes with high‐molecular‐weight HA augmented the stability and cellular transfection ability of the complexes following lyophilization‐rehydration. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - May 1, 2017 Category: Genetics & Stem Cells Authors: Toshinori Sato, Mitsuhiro Nakata, Zhihong Yang, Yu Torizuka, Satoko Kishimoto, Masayuki Ishihara Tags: RESEARCH ARTICLE Source Type: research
Sustained secretion of anti ‐TNF alpha monoclonal antibody from ex‐vivo genetically engineered dermal tissue demonstrates therapeutic activity in mouse model of rheumatoid arthritis
ConclusionsThis work demonstrates micro dermal tissues engineered to secrete active adalimumab as a proof of concept for antibody sustained secretion from the novel ex‐vivo gene therapy TARGT platform. This technology may now be applied to a range of antibodies for the therapy of other diseases. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - May 1, 2017 Category: Genetics & Stem Cells Authors: Inbal Zafir ‐Lavie, Reem Miari, Shay Sherbo, Simi Krispel, Osnat Tal, Atar Liran, Tamar Shatil, Felix Badinter, Haim Goltsman, Nir Shapir, Itai Benhar, Garry A. Neil, Amos Panet Tags: RESEARCH ARTICLE Source Type: research
Association of TNFSF13 polymorphisms with IgA nephropathy in Chinese Han population
ConclusionsOur results indicated that the genetic variations and gene expression level of TNFSF13 were associated with the susceptibility and severity of IgAN in Han Chinese population. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - May 1, 2017 Category: Genetics & Stem Cells Authors: Zhong Zhong, Shao ‐Zhen Feng, Ri‐Cong Xu, Zhi‐Jian Li, Feng‐Xian Huang, Pei‐Ran Yin, Wen‐Ting Liu, Meng Wang, Dian‐Chun Shi, Qian Zhou, Xue‐Qing Yu, Ming Li Tags: RESEARCH ARTICLE Source Type: research
Polymer functionalized gold nanoparticles as non ‐viral gene delivery reagents
ConclusionsNon‐viral vectors based on gold nanoparticles covalently coupled with polyethylene glycol (PEG) and Polyethylenimine (PEI) can be used as efficient transfection reagents showing expression levels same or greater than the ones obtained with commercially available lipoplexes. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - May 1, 2017 Category: Genetics & Stem Cells Authors: M. Mar Encabo ‐Berzosa, Maria Sancho‐Albero, Victor Sebastian, Silvia Irusta, Manuel Arruebo, Jesus Santamaria, Pilar Martín Duque Tags: RESEARCH ARTICLE Source Type: research
Developmental history and application of CRISPR in human disease
Abstract
Genome editing tools are programmable artificial nucleases, mainly including zinc‐finger nucleases (ZFNs), transcription activator‐like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeat (CRISPR). By recognizing and cleaving specific DNA sequences, genome editing tools make it possible to generate site‐specific DNA double‐strand breaks (DSBs) in the genome. DSBs will then be repaired by either error‐prone non‐homologous end joining (NHEJ) or high‐fidelity homologous recombination (HR) mechanisms. Through these two different mechanisms, endogenous genes can be kno...
Source: The Journal of Gene Medicine - May 1, 2017 Category: Genetics & Stem Cells Authors: Puping Liang, Xiya Zhang, Yuxi Chen, Junjiu Huang Tags: REVIEW ARTICLE Source Type: research
Variants in MODY genes associated with maternal lipids profiles in second trimester of pregnancy
ConclusionsVariants in MODY genes played critical role in lipid and glucose homeostasis. Future studies will be required to further clarify the molecular mechanisms underlying these observed associations. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - May 1, 2017 Category: Genetics & Stem Cells Authors: Xiaojing Wang, Wei Li, Liangkun Ma, Fan Ping, Juntao Liu, Xueyan Wu, Jiangfeng Mao, Xi Wang, Min Nie Tags: RESEARCH ARTICLE Source Type: research
Correlation analysis of HLA ‐DPB1*05:01 gene and BTNL2 gene within MHC region with clinical phenotype of psoriasis vulgaris in the Chinese Han population
ConclusionsWe indicates that HLA‐DPB1*05:01 gene was associated with the geographical region of PV and BTNL2 gene was significant association with family history and age of onset of PV. In conclusion, the HLA‐DPB1*05:01 gene and BTNL2 gene might cause the complicacy of clinical features. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - May 1, 2017 Category: Genetics & Stem Cells Authors: Huimin Guo, Yong Huang, Juan Wu, Xiaodong Zheng, Lei Ye, Hequn Huang, Wenjun Wang, Qi Zhen, Jing Wu, Wenjun Qian, Hui Cheng, Xing Fan, Xuejun Zhang Tags: RESEARCH ARTICLE Source Type: research
Issue Information
No abstract is available for this article. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - April 21, 2017 Category: Genetics & Stem Cells Tags: ISSUE INFORMATION Source Type: research
Oxidative stress gene polymorphisms may have an impact in the development of ischemic stroke
ConclusionsIt is unlikely that CAT and GPX1 single nucleotide polymorphisms are risk factors for IS. The results of the present study show that smoking may be a risk factor for IS risk in patients with MnSOD mutant genotypes. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - April 4, 2017 Category: Genetics & Stem Cells Authors: Bensu Karahalil, Aylin Elkama, G ürdal Orhan Tags: RESEARCH ARTICLE Source Type: research
Issue Information
No abstract is available for this article. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - April 4, 2017 Category: Genetics & Stem Cells Tags: ISSUE INFORMATION Source Type: research
Association of ARHGAP22 gene polymorphisms with the risk of type 2 diabetic retinopathy
ConclusionsOur findings reveal a significant association between SNPs in the ARHGAP22 gene and DR risk in a Han Chinese population. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - April 1, 2017 Category: Genetics & Stem Cells Authors: Rong Li, Peng Chen, Jing Li, Mengdan Yan, Jingjie Li, Shanqu Li, Hongli Zhu Tags: RESEARCH ARTICLE Source Type: research
