COX2 and NOS3 gene polymorphisms in women with gestational diabetes
ConclusionThe results of our study suggest that that the CC genotype of COX2 rs6681231 polymorphism is associated with increased risk of GDM and need of insulin therapy, whereas TT genotype of NOS3 rs1799983 polymorphism may be associated with need of insulin therapy in women with GDM. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - April 1, 2017 Category: Genetics & Stem Cells Authors: Maciej Tarnowski, Marta Tkacz, Violetta Dziedziejko, Krzysztof Safranow, Andrzej Pawlik Tags: RESEARCH ARTICLE Source Type: research
Response to the letter to the editor by D. Yuan: “Risk of high altitude pulmonary edema and telomere length”
(Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - April 1, 2017 Category: Genetics & Stem Cells Authors: Dongya Yuan Tags: RESPONSE TO A LETTER Source Type: research
Systemic tumor ‐targeted sodium iodide symporter (NIS) gene therapy of hepatocellular carcinoma mediated by B6 peptide polyplexes
ConclusionsThese results clearly demonstrate that systemic in vivo NIS gene transfer using nanoparticle vectors coupled with B6 tumor‐targeting ligand is capable of inducing tumor‐specific radioiodide uptake. This promising gene therapy approach opens the exciting prospect of NIS‐mediated radionuclide therapy in metastatic cancer together with the possibility of combining several targeting ligands to enhance selective therapeutic efficacy in a broad field of cancer types with various receptor expression profiles. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - March 1, 2017 Category: Genetics & Stem Cells Authors: Sarah Urnauer, Kathrin Klutz, Geoffrey K Gr ünwald, Stephan Morys, Nathalie Schwenk, Christian Zach, Franz‐Josef Gildehaus, Wolfgang Roedl, Manfred Ogris, Ernst Wagner, Christine Spitzweg Tags: RESEARCH ARTICLE Source Type: research
Polymorphisms in the SRNPN gene are associated with obesity susceptibility among Spanish population
ConclusionsTo our knowledge, this is the first study reporting an association between variability in the SNRPN gene with the risk of being obese. Interestingly, it was the major allele of each SNP, which was found associated with the risk of weight gain. Further studies analyzing this locus, and the possible additive deleterious capability of SNPs combinations, could be useful to demonstrate the obesity development. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - March 1, 2017 Category: Genetics & Stem Cells Authors: David Albuquerque, Lic ínio Manco, Luz M González, Guillermo Gervasini, Goitzane Marcaida Benito, Juan R González, Raquel Rodríguez‐López Tags: RESEARCH ARTICLE Source Type: research
Association of IGF1 gene polymorphism with Parkinson's disease in a Han Chinese population
ConclusionsOur study shows that rs972936 polymorphism may increase susceptibility to PD, especially in males and late‐onset patients. Further, high serum IGF1 levels may be a potential diagnostic biomarker for PD in the Han Chinese population, but does not correlate with more severe motor dysfunction. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - February 20, 2017 Category: Genetics & Stem Cells Authors: Yousheng Xiao, Luan Cen, Mingshu Mo, Xiang Chen, Shuxuan Huang, Lei Wei, Shaomin Li, Xinling Yang, Shaogang Qu, Zhong Pei, Pingyi Xu Tags: RESEARCH ARTICLE Source Type: research
Integration of expression quantitative trait loci and pleiotropy identifies a novel psoriasis susceptibility gene, PTPN1
ConclusionsThe results of the present study highlight the expression quantitative trait loci enrichment and pleiotropy in psoriasis and schizophrenia, and also suggest a possible key role of the PTPN1 gene in the etiology of psoriasis. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - January 31, 2017 Category: Genetics & Stem Cells Authors: Xianyong Yin, Yuan Lin, Changbing Shen, Ling Wang, Xianbo Zuo, Xiaodong Zheng, Sen Yang, Jianjun Liu, Kirk C. Wilhelmsen, Xuejun Zhang Tags: RESEARCH ARTICLE Source Type: research
MicroRNA ‐4656 is a prognostic factor and tumor suppressor in human pancreatic cancer through a downstream target of TrkA
ConclusionsMiR‐4656 is expressed to a low extent and is a potential biomarker in PC. Overexpressing miR‐4656 has tumor suppressive effects on PC development both in vitro and in vivo, likely through its downstream target of the TrkA gene. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - January 31, 2017 Category: Genetics & Stem Cells Authors: Xianglong Tan, Jinyong Lv, Guodong Zhao, Zhiming Zhao, Chenggang Li, Yong Xu, Minggen Hu Tags: RESEARCH ARTICLE Source Type: research
ZNF208 polymorphisms associated with ischemic stroke in a southern Chinese Han population
ConclusionsThe results obtained in the present study indicate a potential association between ZNF208 variants and the risk of ischemic risk in a southern Chinese Han population. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - January 31, 2017 Category: Genetics & Stem Cells Authors: Jianzhong Yu, Feng Zhou, Dong Luo, Nianzhen Wang, Chong Zhang, Tianbo Jin, Xiongfei Liang, Dan Yu Tags: RESEARCH ARTICLE Source Type: research
Issue Information
No abstract is available for this article. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - January 31, 2017 Category: Genetics & Stem Cells Tags: ISSUE INFORMATION Source Type: research
Design of pH ‐sensitive peptides from natural antimicrobial peptides for enhancing polyethylenimine (PEI)‐mediated gene transfection
ConclusionsThe results indicate that replacement of positively charged residues with glutamic acid residues in the AMP sequence yields pH‐sensitive peptides, which enhance the transfection efficiency of PEI/DNA polyplexes in various cell lines. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - January 1, 2017 Category: Genetics & Stem Cells Authors: Shi ‐Kun Zhang, Jin‐wen Song, Su‐Bo Li, Hong‐Wei Gao, Hong‐Yu Chang, Li‐li Jia, Feng Gong, Ying‐Xia Tan, Shou‐Ping Ji Tags: RESEARCH ARTICLE Source Type: research
Stent mediated Gene and Drug delivery for Cardiovascular Disease and Cancer: a brief insight
ConclusionFurther delve into improvisation of next generation DES to an extent has helped in overcoming the issue of restenosis. However, current stent formulations fall short of anticipated clinically meaningful outcomes and there is an explicit need for more randomized trials to further evaluate stent platforms in favour of enhanced safety and clinical value. GES may hold promise in contributing new ideas for stent based prevention of in‐stent restenosis through genetic interventions by capitalizing wide variety of molecular targets. Therefore, the heart of the matter directs us to foresee in finding an ideal stent the...
Source: The Journal of Gene Medicine - January 1, 2017 Category: Genetics & Stem Cells Authors: Akshaya Krishnagopal, Aakash Reddy, Dwaipayan Sen Tags: REVIEW ARTICLE Source Type: research
Skewed X ‐chromosome inactivation plays a crucial role in the onset of symptoms in carriers of Becker muscular dystrophy.
ConclusionsThese data suggest that the onset of symptoms in BMD carriers is related to a skewed XCI, as observed in DMD carriers. Furthermore they showed no concordance in the XCI pattern inheritance. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 31, 2016 Category: Genetics & Stem Cells Authors: Emanuela Viggiano, Esther Picillo, Manuela Ergoli, Alessandra Cirillo, Stefania Del Gaudio, Luisa Politano Tags: RESEARCH ARTICLE Source Type: research
Discovery of MYH14 as an important and unique deafness gene causing prelingually severe autosomal dominant non ‐syndromic hearing loss
ConclusionsHerein, we report that MYH14 can manifest as non‐syndromic prelingual severe SNHL in an AD fashion in Koreans. Our study suggests that further genetic studies of similar patients should consider MYH14 as a causative gene, and cochlear implantation during infant or early childhood should be indicated for these patients with certain MYH14 pathogenic variants. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 31, 2016 Category: Genetics & Stem Cells Authors: Bong Jik Kim, Ah Reum Kim, Jin Hee Han, Chung Lee, Doo Yi Oh, Byung Yoon Choi Tags: RESEARCH ARTICLE Source Type: research
Clinical and molecular cytogenetic analyses of four families with 1q21.1 microdeletion or microduplication
Conclusion1q21.1 microdeletion and microduplication exhibit a variety of clinical manifestations and the specificity of their clinical features is not high. The penetrance of distal 1q21.1 microdeletion may be affected by other factors in this study. This study discovered an new distal 1q21.1 microduplication, which enriches CNV spectrum in 1q21.1 region and is conducive to prenatal genetic counseling. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 31, 2016 Category: Genetics & Stem Cells Authors: Hong ‐dan Wang, Lin Liu, Dong Wu, Tao Li, Cun‐ying Cui, Lian‐zhong Zhang, Cheng‐zeng Wang Tags: RESEARCH ARTICLE Source Type: research
Oxidative stress gene polymorphisms may have impact in the development of ischemic stroke
ConclusionIt is unlikely that CAT and GPX1 SNPs are risk factors for IS. Our results showed that smoking may be a risk factor for IS risk in patients having MnSOD mutant genotypes. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - December 31, 2016 Category: Genetics & Stem Cells Authors: Bensu Karahalil, Aylin Elkama, G ürdal Orhan Tags: RESEARCH ARTICLE Source Type: research
