Skewed X ‐chromosome inactivation plays a crucial role in the onset of symptoms in carriers of Becker muscular dystrophy.

ConclusionsThese data suggest that the onset of symptoms in BMD carriers is related to a skewed XCI, as observed in DMD carriers. Furthermore they showed no concordance in the XCI pattern inheritance.

Source: The Journal of Gene Medicine - December 31, 2016 Category: Genetics & Stem Cells Authors: Emanuela Viggiano, Esther Picillo, Manuela Ergoli, Alessandra Cirillo, Stefania Del Gaudio, Luisa Politano Tags: RESEARCH ARTICLE Source Type: research