Promoter Optimisation of Lentiviral Vectors for Efficient Insulin Gene Expression in Canine Mesenchymal Stromal Cells: Potential Surrogate Beta Cells

ConclusionOur results suggest that optimised lentiviral transduction of the insulin gene into primary canine MSCs renders these cells capable of secreting insulin both short‐ and long‐term, in sufficient quantities in vitro to support their potential use in insulin gene therapy.

Source: The Journal of Gene Medicine - July 31, 2016 Category: Genetics & Stem Cells Authors: Pratigya Gautam, Robert D. Foale, Asha Recino, Jing Zhao, Shu Uin Gan, Maja Wallberg, Roy Calne, Andrew M. L. Lever Tags: Research Article Source Type: research