Redesigned E.coli cytosine deaminase: a new facet of suicide gene therapy

ConclusionWe have presented a novel bacterial CD mutant, which provided a superior alternate to wild type CD suicide gene. F186W mutant required a much less dose of 5‐FC to reach its IC50, thus minimizing the systemic side effects of large doses of 5‐FC as required for wtCD. This article is protected by copyright. All rights reserved.

Source: The Journal of Gene Medicine - March 1, 2015 Category: Genetics & Stem Cells Authors: Md. Asif Raza, V. Kohila, Siddhartha Sankar Ghosh Tags: Research Article Source Type: research