Combination of Sequence‐defined Oligoaminoamides with Transferrin‐polycation Conjugates for Receptor‐Targeted Gene Delivery

ConclusionsUtilizing the synergistic effects of Tf for receptor targeting and oligomer for packaging and endolysosomal escape, an efficient gene delivery carrier was developed. The mixed polyplex containing Tf‐polycation conjugates and histidinylated 4‐arm oligomer with Stp or Gtt building blocks exhibited highest gene transfection efficiency in TfR over expressing human tumor cell lines.

Source: The Journal of Gene Medicine - June 1, 2015 Category: Genetics & Stem Cells Authors: Wei Zhang, Wolfgang Rödl, Dongsheng He, Markus Döblinger, Ulrich Lächelt, Ernst Wagner Tags: Research Article Source Type: research