Redesigned Escherichia coli cytosine deaminase: a new facet of suicide gene therapy

ConclusionsWe report a novel bacterial CD mutant that provided a superior alternate to the wtCD suicide gene. The F186W mutant required a much lower dose of 5‐FC to reach its IC50, thus minimizing the systemic side effects of large doses of 5‐FC as required for wtCD. Copyright © 2015 John Wiley & Sons, Ltd.

Source: The Journal of Gene Medicine - July 24, 2015 Category: Genetics & Stem Cells Authors: Asif Raza, V. Kohila, Siddhartha Sankar Ghosh Tags: Research Article Source Type: research