Gene delivery targeted to oligodendrocytes using a lentiviral vector

ConclusionsLentiviral gene delivery using oligodendrocyte‐specific promoter may achieve widespread and long lasting expression selectively in oligodendrocytes offering a possibility for gene therapy in certain leukodystrophies, although the relatively low rates of oligodendrocyte transduction is a limitation that remains to be overcome. This article is protected by copyright. All rights reserved.

Source: The Journal of Gene Medicine - September 1, 2014 Category: Genetics & Stem Cells Authors: Alexia Kagiava, Irene Sargiannidou, Stavros Bashiardes, Jan Richter, Natasa Schiza, Christina Christodoulou, Angela Gritti, Kleopas A. Kleopa Tags: Research Article Source Type: research