Low RNA translation activit limits the efficacy of hydrodynamic gene transfer to pig liver in vivo

ConclusionsThe results suggest that the low activity of mRNA translation limits the final efficacy of the gene transfer procedure. On the other hand, the gold nanoparticles study suggests that elongated DNA conformation could offer advantages in that the access of 15‐nm particles is very limited. Copyright © 2014 John Wiley & Sons, Ltd.

Source: The Journal of Gene Medicine - August 25, 2014 Category: Genetics & Stem Cells Authors: Luis Sendra, Omar Carreño, Antonio Miguel, Eva Montalvá, María José Herrero, Francisco Orbis, Inmaculada Noguera, Domingo Barettino, Rafael López‐Andújar, Salvador F. Aliño Tags: Research Article Source Type: research