Histidine-rich glycoprotein and idiopathic pulmonary fibrosis
Histidine-rich glycoprotein (HRG) is an enigmatic glycoprotein able to interact with a variety of ligands such as IgG, complement components, heparan sulfate, thrombospondin, fibrinogen and plasminogen. HRG is present at high concentrations in plasma and there is evidence indicating that it is able to modulate the course of biological processes such as angiogenesis, fibroblast proliferation, complement activation, coagulation and fibrinolysis. Because these processes are involved in the pathogeneses of lung fibrosis we here analyzed a possible link between HRG and idiopathic pulmonary fibrosis (IPF). (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 27, 2015 Category: Respiratory Medicine Authors: G. Ernst, E. Dantas, J. Sabatté, F. Caro, A. Salvado, P. Grynblat, J. Geffner Tags: Short communication Source Type: research
THE CAT (COPD Assessment Test) QUESTIONNAIRE AS A PREDICTOR of the evolution of severe COPD EXACERBATIONs
Since exacerbations of chronic obstructive pulmonary disease (COPD) cause both a great impact on the progression of the disease and generate high health expenditures, there is a need to develop tools to evaluate their prognosis. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 27, 2015 Category: Respiratory Medicine Authors: Patricia García-Sidro, Elsa Naval, Carlos Martinez Rivera, Marc Bonnin-Vilaplana, Juan Luís Garcia-Rivero, Alberto Herrejón, Rosa Malo de Molina, Pedro Jorge Marcos, Sagrario Mayoralas-Alises, Jose Antonio Ros, Manuel Valle, Cristina Esquinas, Miriam B Source Type: research
AIR: Advances in Respiration – Music therapy in the treatment of chronic pulmonary disease
The aim of this randomized control study is to examine the effect of a multimodal psycho-music therapy intervention on respiratory symptoms, psychological well-being and quality of life of patients with Chronic Obstructive Pulmonary Disease and other lung diseases as adjunct to Pulmonary Rehabilitation with a design of music therapy plus PR compared to Pulmonary Rehabilitation alone. Music therapy group treatment including music visualization, wind playing and singing was provided weekly. This was compared with standard care treatment. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 19, 2015 Category: Respiratory Medicine Authors: Bernardo Canga, Ronit Azoulay, Jonathan Raskin, Joanne Loewy Tags: Clinical trial paper Source Type: research
AIR: Advances in Respiration- Music Therapy in the Treatment of Chronic Pulmonary Disease
The aim of this randomized control study is to examine the effect of a multimodal psycho-music therapy intervention on respiratory symptoms, psychological well-being and quality of life of patients with Chronic Obstructive Pulmonary Disease and other lung diseases as adjunct to Pulmonary Rehabilitation with a design of music therapy plus PR compared to Pulmonary Rehabilitation alone.Music therapy group treatment including music visualization, wind playing and singing was provided weekly. This was compared with standard care treatment. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 19, 2015 Category: Respiratory Medicine Authors: Bernardo Canga, Ronit Azoulay, Jonathan Raskin, Joanne Loewy Tags: Clinical Trial Paper Source Type: research
Differences in change in coping styles between good responders, moderate responders and non-responders to pulmonary rehabilitation
Pulmonary rehabilitation (PR) improves exercise tolerance and health status in patients with chronic obstructive pulmonary disease (COPD). Data on the effects of PR on coping styles are limited. Aim of the present study was to compare changes in coping styles between patients who had a good, moderate and no improvement in either exercise tolerance or health status after PR. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 14, 2015 Category: Respiratory Medicine Authors: Ana Stoilkova-Hartmann, Daisy J.A. Janssen, Frits M.E. Franssen, Emiel F.M. Wouters Source Type: research
Emerging role of Long Noncoding RNAs in lung cancer: current status and future prospects
Lung cancer is the leading cause of cancer-related death worldwide with a 5-year survival rate of less than 15%, despite significant advances in both diagnostic and therapeutic approaches. Combined genomic and transcriptomic sequencing studies have identified numerous genetic driver mutations that are responsible for the development of lung cancer. Importantly, these approaches have also uncovered the widespread expression of “noncoding RNAs” including long noncoding RNAs (LncRNAs), which impact biologic responses through the regulation of mRNA transcription or translation. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 13, 2015 Category: Respiratory Medicine Authors: Hui Tao, Jing-Jing Yang, Xiao Zhou, Zi-Yu Deng, Kai-Hu Shi, Jun Li Tags: Review article Source Type: research
Comparative analysis of clinical profile: Chronic cough vs paradoxical vocal fold motion
Ongoing contention surrounding typical demographic and clinical attributes of chronic cough (CC) and paradoxical vocal fold motion (PVFM) impedes timely diagnosis and optimum patient care. Designed to reduce preventable patient morbidity through improved recognition and differentiation, the current study aimed to determine representative clinical profiles for CC and PVFM, with identification of distinctive attributes from the general population and risk factors associated with each diagnosis. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 13, 2015 Category: Respiratory Medicine Authors: Naomi A. Hartley, Brian E. Petty, Bethany Johnson, Susan L. Thibeault Source Type: research
A microsimulation model for the development and progression of chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease that is thought to affect over one million people in Great Britain (HSE 2014). The main factor contributing to the development of COPD is tobacco smoke. This paper presents a microsimulation model for the development of COPD, incorporating population dynamics and trends in smoking. The model simulates a population longitudinally throughout their lifetimes, providing projections of future COPD prevalence and evaluation of the effects of changes in risk factor prevalence such as smoking. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 12, 2015 Category: Respiratory Medicine Authors: Emma Tan, Ruud Boessen, David Fishwick, Rinke Klein Entink, Tim Meijster, Anjoeka Pronk, Birgit van Duuren-Stuurman, Nick Warren Source Type: research
The usefulness of KL-6 and SP-D for the diagnosis and management of chronic hypersensitivity pneumonitis
It is believed that Krebs von den Lungen-6 (KL-6) and surfactant protein D (SP-D) are useful biomarkers for the diagnosis of various types of interstitial lung diseases, including hypersensitivity pneumonitis (HP). The clinical features of chronic HP are similar to those of idiopathic interstitial pneumonias, especially idiopathic pulmonary fibrosis (IPF). (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 12, 2015 Category: Respiratory Medicine Authors: Tsukasa Okamoto, Mayumi Fujii, Haruhiko Furusawa, Kimitake Tsuchiya, Yasunari Miyazaki, Naohiko Inase Source Type: research
Pulmonary Manifestations of Renal Cell Carcinoma
Renal cell carcinoma (RCC) accounts for majority of all primary renal neoplasms. Classic manifestations of RCC include the triad of flank pain, hematuria and a palpable renal mass. Patients with RCC can develop various extra renal manifestations including involvements of the lungs, inferior vena cava, liver and the bones. The pulmonary manifestations of renal cell carcinoma include metastatic disease including endobronchial, pleural, parenchymal or lymph node metastasis, pleural effusion or hemothorax. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 8, 2015 Category: Respiratory Medicine Authors: Abhinav Agrawal, Sonu Sahni, Asma Iftikhar, Arunabh Talwar Tags: Review article Source Type: research
Using EMR to Improve Compliance with Clinical Practice Guidelines for Management of Stable COPD
Clinical practice guidelines are underutilized in the outpatient management of chronic obstructive pulmonary disease (COPD). We hypothesize that a structured approach using the electronic medical record (EMR) will improve compliance with clinical practice guidelines for the evaluation and management of patients with stable COPD. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 8, 2015 Category: Respiratory Medicine Authors: Jordan Terasaki, Gurinder Singh, Wei Zhang, Penny Wagner, Gulshan Sharma Source Type: research
Understanding Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome
Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) is a loosely-defined clinical entity referring to patients who exhibit characteristics of both asthma and chronic obstructive pulmonary disease (COPD). Clinical definitions and classifications for ACOS vary widely, which impacts our understanding of prevalence, diagnosis and treatment of the condition.This literature review was therefore conducted to characterize the prevalence of ACOS and the effect of different disease definitions on these estimates, as this has not previously been explored. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 8, 2015 Category: Respiratory Medicine Authors: Keele E. Wurst, Kaitlin Kelly-Reif, Greta Bushnell, Steven Pascoe, Neil Barnes Tags: Review article Source Type: research
Effect of a single 1200 Mg dose of Mucinex on mucociliary and cough clearance during an acute respiratory tract infection
Observational studies suggest that orally administered guaifenesin (GGE) may thin lower respiratory tract secretions but none have examined its effects on mucociliary and cough clearance (MCC/CC) during a respiratory tract infection (RTI). The current study was a randomized, parallel-group, double-blind, placebo-controlled study in non-smoking adults who suffered from an acute upper RTI. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 5, 2015 Category: Respiratory Medicine Authors: W.D. Bennett, A. Kala, H. Duckworth, K.L. Zeman, J. Wu, A. Henderson, M. Yopp, B.K. Rubin Source Type: research
Type 2 innate lymphoid cells: A novel biomarker of eosinophilic airway inflammation in patients with mild to moderate asthma
Eosinophilic airway inflammation can predict the exacerbation of asthma, and we can improve the management of asthma by monitoring the eosinophilic airway inflammation. Although induced sputum and sputum eosinophil count is the gold standard test for diagnosing eosinophilic asthma, a more accessible and receptive method is needed for clinical practice. Type 2 innate lymphoid cells (ILC2) have recently been proposed to play a crucial role in eosinophilic inflammation and have been identified in peripheral blood from patients with asthma. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 5, 2015 Category: Respiratory Medicine Authors: Tian Liu, Jinxiang Wu, Jiping Zhao, Junfei Wang, Yuanyuan Zhang, Lin Liu, Liuzhao Cao, Yahui Liu, Liang Dong Source Type: research
Effect Of A Single 1200 Mg Dose Of Mucinex On Mucociliary And Cough Clearance During An Acute Respiratory Tract Infection
Observational studies suggest that orally administered guaifenesin (GGE) may thin lower respiratory tract secretions but none have examined its effects on mucociliary and cough clearance (MCC/CC) during a respiratory tract infection (RTI). The current study was a randomized, parallel-group, double-blind, placebo-controlled study in non-smoking adults who suffered from an acute upper RTI. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 5, 2015 Category: Respiratory Medicine Authors: W.D. Bennett, A. Kala, H. Duckworth, K.L. Zeman, J. Wu, A. Henderson, M. Yopp, B.K. Rubin Source Type: research
