What are the characteristics of asthma patients with elevated serum IgG4 levels?
IgG4 has recently been a subject of great interest in human pathology. No data are available about the characteristics of asthma patients with elevated IgG4 levels. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - January 22, 2016 Category: Respiratory Medicine Authors: T. Flament, S. Marchand-Adam, P. Gatault, C. Dupin, P. Diot, L. Guilleminault Source Type: research
Response to Dr. Rutten's comment on “Serum magnesium and not vitamin D is associated with better QoL in COPD: A cross-sectional study”
Thank you to Dr. Rutten for the comment on our manuscript “Serum magnesium and not vitamin D is associated with better QoL in COPD: A cross-sectional study”. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - January 20, 2016 Category: Respiratory Medicine Authors: Sarah Hashim Ali Hussein, Lars Peter Nielsen, Mette Konow Bøgebjerg Dolberg, Ronald Dahl Tags: Correspondence Source Type: research
Response to Dr. Rutten’s comment on ”Serum magnesium and not vitamin D is associated with better QoL in COPD: A cross-sectional study”
Thank you to Dr. Rutten for the comment on our manuscript "Serum magnesium and not vitamin D is associated with better QoL in COPD: A cross-sectional study". (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - January 20, 2016 Category: Respiratory Medicine Authors: Sarah Hashim Ali Hussein, Lars Peter Nielsen, Mette Konow Bøgebjerg Dolberg, Ronald Dahl Source Type: research
Comment on “Serum magnesium and not vitamin D is associated with better QoL in COPD: A cross-sectional study”
Dr. Hashim Ali Hussein et al have recently published a manuscript concerning serum levels of different micronutrients in relation to lung function and health related quality of life in patients with COPD [1]. This is a relevant topic since COPD is a heterogeneous disease and it has been reported that the dietary quality of many COPD patients is poor [2]. The authors concluded that most patients have sufficient vitamin D (VD), calcium and magnesium levels, and that none of these are related to lung function. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - January 20, 2016 Category: Respiratory Medicine Authors: Erica P.A. Rutten Source Type: research
School environmental factors are predictive for exercise-induced symptoms in children
Environmental factors in schools have a significant effect on the exercise-induced bronchoconstriction and symptoms in a general paediatric population. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - January 20, 2016 Category: Respiratory Medicine Authors: Iwona Stelmach, Lukasz Cichalewski, Paweł Majak, Katarzyna Smejda, Daniela Podlecka, Joanna Jerzyńska, Włodzimierz Stelmach Source Type: research
The epidemiology of asthma and its comorbidities in Poland – Health problems of patients with severe asthma as evidenced in the Province of Lodz
Population studies supply interesting data regarding the epidemiology, comorbidity and risk factors of asthma, which have direct clinical implications for patients. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - January 19, 2016 Category: Respiratory Medicine Authors: Michał Panek, Łukasz Mokros, Tadeusz Pietras, Piotr Kuna Source Type: research
The epidemiology of asthma and its comorbidities in Poland - health problems of patients with severe asthma as evidenced in the Province of Lodz
Asthma is a serious health, social and economic problem both in Poland and worldwide. According to the World Health Organization (WHO), asthma affects approximately 300 million people worldwide, with morbidity ranging from 1 to 18%; Around 5% suffer from the severe form, and around 1% the very severe form [1,2]. Poland alone includes around 4 million asthma patients. Morbidity in the adult population is known to be 5.4% [3,4], with the majority of sufferers being female. A dynamic increase has been observed in the number of cases for more than 30 years [2,3,4] and despite the implementation of modern inhaled drugs, systemi...
Source: Respiratory Medicine CME - January 19, 2016 Category: Respiratory Medicine Authors: Michał Panek, Łukasz Mokros, Tadeusz Pietras, Piotr Kuna Source Type: research
Response to Letter to the Editor: “Risk factors for postoperative pneumonia after lung cancer surgery and impact of pneumonia on survival”
It was with great interest that we read the letter to the editor by Cavalheri and Hill regarding our paper “Risk factors for postoperative pneumonia after lung cancer surgery and impact of pneumonia on survival”. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - January 14, 2016 Category: Respiratory Medicine Authors: Dennis Fristrup Simonsen, Reimar Wernich Thomsen Source Type: research
Current thinking and new paradigm for COPD
During the 2015 European Respiratory Society Congress, a symposium was held on ‘Current thinking and new paradigm for COPD’. Through a combination of plenary lectures and interactive panel discussions, experts discussed the recent evidence for chronic obstructive pulmonary disease (COPD) treatment and how this evidence can be applied in clinical practice. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - January 13, 2016 Category: Respiratory Medicine Authors: Tobias Welte, Kenneth R. Chapman, Helgo Magnussen, Marc Miravitlles Tags: Short communication Source Type: research
The efficacy of fluticasone furoate administered in the morning or evening is comparable in patients with persistent asthma
The inhaled corticosteroid fluticasone furoate (FF) is efficacious as a once-daily treatment for the management of asthma. Asthma is associated with circadian changes, with worsening lung function at night. We compared the efficacy of once-daily FF in the morning or evening for the treatment of asthma.MethodsAdults with persistent bronchial asthma were enrolled into this randomised, repeat-dose, double-blind, double-dummy, placebo-controlled, three-way crossover study. After a 14-day run-in period, patients received either: FF 100 μg in the morning (AM); FF 100 μg in the evening (PM); or placebo, via the ELLIPTA® dry ...
Source: Respiratory Medicine CME - January 11, 2016 Category: Respiratory Medicine Authors: R.D. Kempsford, J. Bal, A. Baines, J. Renaux, R. Ravindranath, P.S. Thomas Source Type: research
Reductions in eosinophil biomarkers by benralizumab in patients with asthma
Eosinophilic inflammation is frequently associated with increased asthma severity. Benralizumab is a humanized, afucosylated, anti–interleukin-5Rα monoclonal antibody that selectively depletes eosinophils and basophils through enhanced antibody-dependent cell-mediated cytotoxicity. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - January 8, 2016 Category: Respiratory Medicine Authors: Tuyet-Hang Pham, Gautam Damera, Paul Newbold, Koustubh Ranade Source Type: research
Magnitude of umeclidinium/vilanterol lung function effect depends on monotherapy responses: results from two randomised controlled trials
Dual therapy with bronchodilators of different pharmacological classes may produce greater lung function improvements than either drug alone. However, the relationship between a patient’s response to monotherapy and response to dual bronchodilator therapy is currently unknown. We aimed to investigate whether dual therapy with umeclidinium/vilanterol provides additional benefit over umeclidinium or vilanterol monotherapy in patients with chronic obstructive pulmonary disease (COPD) identified as responsive (increase from baseline in forced expiratory volume in 1s [FEV1] of ≥12% and ≥200mL, Day 1) or non-responsive to ...
Source: Respiratory Medicine CME - January 6, 2016 Category: Respiratory Medicine Authors: James F. Donohue, Dave Singh, Clara Munzu, Sally Kilbride, Alison Church Source Type: research
The single breath nitrogen test and mortality – A 38 years follow up
Spirometry data predict mortality, but are less sensitive to detect dysfunction in small airways as compared to the slope of phase III (the N2 slope) of the single breath nitrogen test. The association between the N2 slope and mortality has been studied with conflicting results. In the present study the prognostic importance of the N2 slope was tested taking spirometry variables into account. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - January 6, 2016 Category: Respiratory Medicine Authors: Jan Olofson, Björn Bake, Bengt Bergman, Kurt Svärdsudd Source Type: research
Feasibility to apply eucapnic voluntary hyperventilation in young elite athletes
Introduction: Exercise-induced bronchoconstriction (EIB) is more common in athletes compared to the general population. The eucapnic voluntary hyperventilation test is used to detect EIB in adult athletes. It is however unclear whether this technique is also applicable to young athletes.MethodsYoung athletes (basketball (n = 13), football (n = 19), swimming (n = 12)) were recruited at the start of their elite sports career (12–14 years). Eight age-matched controls were also recruited. Eucapnic voluntary hyperventilation test was performed according to ATS guidelines in all subjects. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - January 4, 2016 Category: Respiratory Medicine Authors: S. Van der Eycken, A. Schelpe, G. Marijsse, E. Dilissen, T. Troosters, V. Vanbelle, S. Aertgeerts, L.J. Dupont, K. Peers, D.M. Bullens, S.F. Seys Tags: Short communication Source Type: research
The ‘real-life’ COPD patient in Germany: The DACCORD study
DACCORD is an ongoing, longitudinal, non-interventional study within the German COPD National Prospective Registry. This manuscript describes the baseline characteristics of the first 5924 participants, recruited between November 2012 and November 2013. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - December 30, 2015 Category: Respiratory Medicine Authors: Heinrich Worth, Roland Buhl, Carl-Peter Criée, Peter Kardos, Claudia Mailänder, Claus Vogelmeier Source Type: research
