Combined pulmonary fibrosis and emphysema: The many aspects of a cohabitation contract
Combined pulmonary fibrosis and emphysema (CPFE) is a clinical entity characterized by the coexistence of upper lobe emphysema and lower lobe fibrosis. Patients with this condition experience severe dyspnea and impaired gas exchange with preserved lung volumes. The diagnosis of the CPFE syndrome is based on HRCT imaging, showing the coexistence of emphysema and pulmonary fibrosis both in varying extent and locations within the lung parenchyma. Individual genetic background seem to predispose to the development of the disease. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 6, 2016 Category: Respiratory Medicine Authors: Andriana I. Papaioannou, Konstantinos Kostikas, Effrosyni D. Manali, Georgia Papadaki, Aneza Roussou, Likurgos Kolilekas, Raphaël Borie, Demosthenis Bouros Prof, Spyridon A. Papiris Tags: Review article Source Type: research
The prevalence of small airways disease in adult asthma: A systematic literature review
Small airways dysfunction and inflammation contribute significantly to the clinical impact of asthma, yet conventional methods of assessing airways function in the clinic cannot reliably evaluate its presence. However, most recently, promising methods of assessment are being utilised. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 6, 2016 Category: Respiratory Medicine Authors: Omar S. Usmani, Dave Singh, Monica Spinola, Andrea Bizzi, Peter J. Barnes Tags: Review article Source Type: research
Long-term safety of aclidinium bromide/formoterol fumarate fixed-dose combination: Results of a randomized 1-year trial in patients with COPD
This was a one-year, Phase III randomized, double-blind, parallel-group active-control study investigating the long-term safety and tolerability of a twice-daily aclidinium 400 μg/formoterol 12 μg versus formoterol 12 μg. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 6, 2016 Category: Respiratory Medicine Authors: James F. Donohue, Weily Soong, Xiao Wu, Pomy Shrestha, Alejhandra Lei Source Type: research
Respiratory drugs and macrolides prevent asthma exacerbations: A real-world investigation
We investigated the real-world effectiveness of several drugs (including short- and long-acting beta-agonists [SABAs and LABAs], inhaled corticosteroids [ICS], and antibiotics) in preventing severe asthma exacerbations by carrying-out a large observational study based on the healthcare utilization databases of the Italian Lombardy Region. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 3, 2016 Category: Respiratory Medicine Authors: Andrea Arf è, Francesco Blasi, Luca Merlino, Giovanni Corrao Source Type: research
Non CF-bronchiectasis: Aetiologic approach, clinical, radiological, microbiological and functional profile in 277 patients
Non-Cystic Fibrosis (CF) bronchiectasis is common in Greece but little attention has been paid to the investigation of its aetiology, clinical, radiological, microbiological and lung function profile. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 2, 2016 Category: Respiratory Medicine Authors: Katerina Dimakou, Christina Triantafillidou, Michail Toumbis, Kyriaki Tsikritsaki, Katerina Malagari, Petros Bakakos Source Type: research
Alpha-1-antitrypsin (SERPINA1) mutation spectrum: Three novel variants and haplotype characterization of rare deficiency alleles identified in Portugal
Alpha-1-antitrypsin deficiency (AATD) is a genetic condition caused by SERPINA1 mutations, which culminates into lower protease inhibitor activity in the serum and predisposes affected individuals to emphysema. Clinical manifestations of AATD are often associated to ZZ (p.Glu342Lys) and SZ (p.Glu264Val) genotypes and less frequently to rare deficiency or null alleles in heterozygous and homozygous states. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 2, 2016 Category: Respiratory Medicine Authors: Deolinda Silva, Maria João Oliveira, Miguel Guimarães, Ricardo Lima, Sílvia Gomes, Susana Seixas Source Type: research
Convex probe EBUS for centrally located parenchymal lesions without a bronchus sign
Convex probe endobronchial ultrasound (CP-EBUS) has proven safe and accurate for identifying malignancy and granulomatous disease affecting the mediastinum and hilum. For the diagnosis of parenchymal lung lesions, conventional techniques such as transbronchial biopsy, brush and lavage are useful, particularly when an airway leads directly to the lesion. For centrally located intraparenchymal lesions, CP-EBUS has been shown to be efficacious. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - April 28, 2016 Category: Respiratory Medicine Authors: A. Christine Argento, Jonathan Puchalski Source Type: research
Lung clearance index for monitoring early lung disease in alpha-1-antitrypsin deficiency
Patients with alpha-1-antitrypsin deficiency (AATD) and a PI-ZZ genotype are at high risk to develop severe emphysema during adulthood. However, little is known about early stages of emphysema and disease manifestation in other PI-types. Spirometry is commonly used for monitoring although early manifestation of emphysema is suspected within the peripheral airways that are not accessible by forced expiratory manoeuvres.We hypothesized that the Lung Clearance Index (LCI) derived from multiple breath nitrogen-washout (N2-washout) is useful to bridge this diagnostic gap. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - April 27, 2016 Category: Respiratory Medicine Authors: Susanne I. Fuchs, Nicolaus Schwerk, Klaus Pittschieler, Frank Ahrens, Winfried Baden, Robert Bals, Sebastian Fähndrich, Wolfgang Gleiber, Matthias Griese, Georg Hülskamp, Thomas Köhnlein, Ludmilla Reckling, Ernst Rietschel, Doris Staab, Monika Gappa Source Type: research
Health literacy and health outcomes in chronic obstructive pulmonary disease
There is little information worldwide about the impact of health literacy (HL) on clinical outcomes of COPD. Our aim was to quantify inadequate HL in Spain, as measured by the Short Assessment of Health Literacy for Spanish Adults questionnaire, and to examine the associations between HL and both COPD outcomes and health status. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - April 27, 2016 Category: Respiratory Medicine Authors: Luis Puente-Maestu, Myriam Calle, Juan Luis Rodríguez-Hermosa, Anna Campuzano, Javier de Miguel Díez, Jose Luis Álvarez-Sala, Luis Puente-Andues, Maria Joselín Pérez Gutiérrez, Shoou-Yih D. Lee Source Type: research
Increased levels of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in idiopathic pulmonary fibrosis
Mac-2 binding protein (M2BP) is a cell-adhesive glycoprotein of the extracellular matrix secreted as a ligand of galectin-3 (Mac-2). Recently, a Wisteria floribunda agglutinin positive-M2BP (WFA+-M2BP) assay developed using a lectin-antibody sandwich immunoassay has shown promise as a new fibrotic marker in liver fibrosis to detect unique fibrosis-related glycoalteration. The aim of this study is to evaluate the utility of serum WFA+-M2BP levels in patients with idiopathic pulmonary fibrosis (IPF). (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - April 24, 2016 Category: Respiratory Medicine Authors: Masato Kono, Yutaro Nakamura, Yoshiyuki Oyama, Kazutaka Mori, Hironao Hozumi, Masato Karayama, Dai Hashimoto, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Masaomi Yamada, Etsuko Hamada, Thomas V. Colby, Masato Maekawa, Takafumi Suda Source Type: research
Respiratory deterioration following laparoscopic adjustable gastric banding: A three-year follow-up of over 3,000 subjects
Obesity is considered a global epidemic. Until recently, laparoscopic adjustable gastric binding (LAGB) was routinely offered as a means of weight reduction for selected patient populations. Previous case series have documented several pulmonary complications following LAGB. In the current study, we explored the rate of long-term respiratory deterioration associated with LAGB. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - April 24, 2016 Category: Respiratory Medicine Authors: Shiri Savir, Or Kalchiem-Dekel, Lechaim Naggan, Nimrod Maimon Source Type: research
Efficacy of adalimumab in sarcoidosis patients who developed intolerance to infliximab
The objective of this retrospective observational study was to establish if adalimumab could achieve stabilization or improvement of the disease in refractory sarcoidosis patients who developed intolerance to infliximab. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - April 21, 2016 Category: Respiratory Medicine Authors: Heleen A. Crommelin, Leone M. van der Burg, Adriane D.M. Vorselaars, Marjolein Drent, Coline H.M. van Moorsel, Ger T. Rijkers, Vera H.M. Deneer, Jan C. Grutters Source Type: research
Does gastroesophageal reflux increase chronic obstructive pulmonary disease exacerbations?
The relationship between chronic obstructive pulmonary disease (COPD) exacerbations and gastroesophageal reflux (GER) has been investigated less than asthma-GER. We aimed to evaluate the presence of GER in patients with COPD and its impact on exacerbations. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - April 18, 2016 Category: Respiratory Medicine Authors: Sinem Iliaz, Raim Iliaz, Seda Tural Onur, Serpil Arıcı, Umit Akyuz, Cetin Karaca, Kadir Demir, Fatih Besisik, Sabahattin Kaymakoglu, Filiz Akyuz Source Type: research
High prevalence of obstructive lung disease in non-smoking farmers: The Irish farmers lung health study
Mortality rates within the Irish farming community are increasing, whilst that of the general population falls. The aim of this cross-sectional study was to determine the prevalence of respiratory disease amongst Irish farmers. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - April 18, 2016 Category: Respiratory Medicine Authors: Breda Cushen, Imran Sulaiman, Noreen Donoghue, Donna Langan, Tara Cahill, Eimear Nic Dhonnacha, Olivia Healy, Fiona Keegan, Mark Browne, Anthony O'Regan Source Type: research
