Influence of effective noninvasive positive pressure ventilation on inflammatory and cardiovascular biomarkers in stable hypercapnic COPD patients
This study investigated the influence of effective NPPV on a panel of cytokines and established cardiovascular biomarkers. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - August 12, 2015 Category: Respiratory Medicine Authors: Michael Dreher, Lisa Schulte, Tobias Müller, Emelie Ekkernkamp, Andreas Zirlik Source Type: research
Searching for the synergistic effect between aclidinium and formoterol: From bench to bedside
Aim of our study was to understand if the interaction between aclidinium and formoterol administered at therapeutic doses leads to a synergistic rather than additive broncholytic effect. We tested the type of effect ex vivo on isolated human bronchi and then in vivo in COPD patients. The analysis of the interaction between aclidinium and formoterol in vitro was measured by applying the Unified Theory, whereas that in COPD patients was measured by applying the Bliss Independence criterion. Aclidinium and formoterol administered alone completely relaxed human isolated bronchial tissues sub-maximally pre-contracted with ACh i...
Source: Respiratory Medicine CME - August 12, 2015 Category: Respiratory Medicine Authors: Mario Cazzola, Luigino Calzetta, Josuel Ora, Ermanno Puxeddu, Paola Rogliani, Maria Gabriella Matera Source Type: research
Reproducibility of the bronchoconstrictive response to eucapnic voluntary hyperpnoea
Eucapnic voluntary hyperpnoea (EVH) is considered an effective bronchoprovocation challenge for identifying exercise-induced bronchoconstriction (EIB). However, the reproducibility of the hyperpnoea-induced bronchoconstriction (HIB) response elicited by EVH remains unknown and was therefore the focus of this study. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - August 12, 2015 Category: Respiratory Medicine Authors: N.C. Williams, M.A. Johnson, K.A. Hunter, G.R. Sharpe Source Type: research
Physical activity in COPD patients decreases short-acting bronchodilator use and the number of exacerbations
Physically inactive patients with chronic obstructive pulmonary disease (COPD) exhibit higher rates of exacerbations and symptoms of dyspnoea than active patients. Whether the use of COPD medication explains these differences is not known. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - August 6, 2015 Category: Respiratory Medicine Authors: Milla Katajisto, Jukka Koskela, Ari Lindqvist, Maritta Kilpeläinen, Tarja Laitinen Source Type: research
Editorial Board
(Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 31, 2015 Category: Respiratory Medicine Source Type: research
The effect of Varenicline on smoking cessation in a group of young asthma patients
Tobacco use causes long-term morbidity and mortality. In patients with asthma, the frequency of smokers is high; however, asthmatic smokers experience more pronounced symptoms, accelerated loss of lung function and treatment resistance. Varenicline is an effective drug in smoking cessation, when investigated in COPD patients and general populations. The aim of the present study was to evaluate the effect of Varenicline on tobacco cessation in young asthmatics. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 30, 2015 Category: Respiratory Medicine Authors: Christian G. Westergaard, Celeste Porsbjerg, Vibeke Backer Source Type: research
Author Reply: Home non-invasive mechanical ventilation use following acute hypercapnic respiratory failure in COPD. A solid protective factor
In our retrospective study we concluded that continued use of home nocturnal NPPV following hospitalization for AECOPD with hypercapnic respiratory failure resulted in lower readmission rates and improved event free survival at 180 days post discharge1. We respond to the questions by Matos et al. as follows: (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 28, 2015 Category: Respiratory Medicine Authors: J.A. Galli, G.J. Criner Tags: Correspondence Source Type: research
Chronic Obstructive Pulmonary Disease and cerebrovascular disease: a comprehensive review
Along with the aging population, the public health burden of cerebrovascular disease is increasing. Cerebral small vessel disease associate and accumulation of brain pathology associate with cognitive decline and can lead to clinical outcomes, such as stroke and dementia. Chronic Obstructive Pulmonary Disease (COPD) is a common respiratory disease among elderly. The quality of life and prognosis of patients with COPD is greatly determined by the presence of comorbidities including stroke and cognitive impairment. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 25, 2015 Category: Respiratory Medicine Authors: Lies Lahousse, Henning Tiemeier, M. Arfan Ikram, Guy G. Brusselle Tags: Review article Source Type: research
Long-term adherence to inhaled corticosteroids in children with asthma: Observational study
Non-adherence to daily controller medication in childhood asthma is strongly dependent on potentially modifiable factors such as parental illness perceptions and medication beliefs. The extent to which adherence in children can be improved by addressing modifiable determinants of non-adherence has not been studied to date, however. We assessed long-term adherence and its determinants in children with asthma enrolled in a comprehensive asthma care program employing shared decision making with parents. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 24, 2015 Category: Respiratory Medicine Authors: Ted Klok, Adrian A. Kaptein, Eric J. Duiverman, Paul L. Brand Source Type: research
Reversibility of pulmonary function after inhaling salbutamol in different doses and body postures in asthmatic children
Pulmonary medication is often delivered in the form of medical aerosols designed for inhalation. Recently, breath actuated inhalers (BAI’s) gained popularity as they can be used without spacers. A major drawback of BAI’s is the impaction in the upper airway. Stretching the upper airway by a forward leaning body posture with the neck extended (“sniffing position”) during inhalation may reduce upper airway impaction and improve pulmonary deposition. Aim of this study was to investigate the reversibility of lung function with different doses salbutamol inhaled with a BAI in the forward leaning posture compared to the ...
Source: Respiratory Medicine CME - July 23, 2015 Category: Respiratory Medicine Authors: R. Visser, S. Kelderman, F.H.C. de Jongh, J. van der Palen, B.J. Thio Source Type: research
Optimizing inhaler use by pharmacist-provided education to community-dwelling elderly
To assess, using a standard observational tool, the ability of patients to demonstrate and maintain proper inhaled medication administration techniques following pharmacist education. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 20, 2015 Category: Respiratory Medicine Authors: Carla Bouwmeester, Jacqueline Kraft, Kathleen M. Bungay Tags: Short communication Source Type: research
Risk Factors for Postoperative Pneumonia after Lung Cancer Surgery and Impact of Pneumonia on Survival
Little is known about risk factors and prognosis for postoperative pneumonia (POP) in patients undergoing therapeutic lung cancer (LC) surgery. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 17, 2015 Category: Respiratory Medicine Authors: Dennis F. Simonsen, Mette Søgaard, Imre Bozi, Charles R. Horsburgh, Reimar W. Thomsen Source Type: research
Airflow limitation in COPD is associated with increased left ventricular wall stress in coincident heart failure
COPD and heart failure occur with a considerable coincidence. Beside well-known mechanisms of increased right heart load in COPD, dedicated changes of the left ventricle (LV) are ill-defined and the question remains, whether specific interactions exist beyond common shared risk factors. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 17, 2015 Category: Respiratory Medicine Authors: Peter Alter, Kirsten van de Sand, Christoph Nell, Jens H. Figiel, Timm Greulich, Claus F. Vogelmeier, Andreas R. Koczulla Source Type: research
Improvements in lung function with umeclidinium/vilanterol versus fluticasone propionate/salmeterol in patients with moderate-to-severe COPD and infrequent exacerbations
We read with interest the article by James F. Donohue et al, which summarized the results of two identical studies on the once-daily (od) long-acting β2-agonist (LABA)/long-acting muscarinic antagonist (LAMA) combination, vilanterol (VIL)/umeclidinium (UMEC) and the twice-daily (bid) LABA/inhaled corticosteroid (ICS) combination salmeterol (SAL)/fluticasone propionate (FP). The primary endpoint was least squares mean change from baseline in 0 to 24-h weighted mean FEV1 versus FP/SAL on Day 84 in patients with moderate-to-severe COPD, without a documented history of COPD exacerbation in the year before screening [1]. (Sour...
Source: Respiratory Medicine CME - July 16, 2015 Category: Respiratory Medicine Authors: Donald Banerji, Francesco Patalano Tags: Correspondence Source Type: research
Prevalence of Eosinophilia in Hospitalized Patients with Asthma Exacerbation
Recent studies have identified the “eosinophilic phenotype” of asthma that is characterized by persistent eosinophilic inflammation and frequent exacerbations. However, the prevalence of eosinophilia in patients hospitalized for asthma exacerbation is not known. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 16, 2015 Category: Respiratory Medicine Authors: Kohei Hasegawa, Samantha J. Stoll, Jason Ahn, Jane C. Bittner, Carlos A. Camargo Tags: Short communication Source Type: research
