Swallowing function and chronic respiratory diseases: Systematic review
The precise coordination between breathing and swallowing is an important mechanism to prevent pulmonary aspiration. Factors that alter breathing patterns and ventilation, such as chronic respiratory diseases, may influence that precise coordination of breathing and swallowing. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - June 1, 2016 Category: Respiratory Medicine Authors: Ines Ghannouchi, Renée Speyer, Kenji Doma, Reinie Cordier, Eric Verin Tags: Review article Source Type: research
Non-invasive screening for pulmonary hypertension in idiopathic pulmonary fibrosis
Pulmonary hypertension (PH) is a common complication of idiopathic pulmonary fibrosis (IPF) that is associated with poor prognosis. Noninvasive screening for PH in IPF patients is challenging and a combination of several noninvasive determinations can improve discrimination. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - June 1, 2016 Category: Respiratory Medicine Authors: Laith Alkukhun, Xiao-Feng Wang, Mostafa Ahmed, Manfred Baumgartner, Marie Budev, Raed A. Dweik, Adriano R. Tonelli Source Type: research
Reply to Letter to the Editor – Capnometry in children with bronchiolitis: A pathophysiological point of view
We appreciate the comments and kind remarks by Jacopo et al. in their letter, Capnometry in children with bronchiolitis: a pathophysiological point of view. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 31, 2016 Category: Respiratory Medicine Authors: Fahed Hakim, Ron Jacob, Lea Bentur Source Type: research
Reply to letter to the editor – Mechanical ventilation in idiopathic pulmonary fibrosis: Unresolved dilemma
We are grateful to Dr's Santos et al. for their comments on our article. Indeed, a critical limitation of studies employing large databases is the lack of granular patient-level data. The character of the underlying disease and the severity of illness at presentation undoubtedly plays a role in determining a patient's suitability for mechanical ventilation, although the significance of individual measures remains unclear [1]. We did not intend to investigate prognostic factors, and further prospective work is needed to help determine which cohort of patients may benefit most from mechanical ventilation (MV). (Source: Res...
Source: Respiratory Medicine CME - May 31, 2016 Category: Respiratory Medicine Authors: Barret Rush, Katie Wiskar, Landon Berger, Donald Griesdale Source Type: research
Reply to Letter to the Editor – Capnometry in children with bronchiolitis: A pathophysiological point of view
We appreciate the comments and kind remarks by Jacopo et al. in their letter, Capnometry in children with bronchiolitis: a pathophysiological point of view. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 31, 2016 Category: Respiratory Medicine Authors: Fahed Hakim, Ron Jacob, Lea Bentur Source Type: research
Reply to letter to the editor – Mechanical ventilation in idiopathic pulmonary fibrosis: Unresolved dilemma
We are grateful to Dr's Santos et al. for their comments on our article. Indeed, a critical limitation of studies employing large databases is the lack of granular patient-level data. The character of the underlying disease and the severity of illness at presentation undoubtedly plays a role in determining a patient's suitability for mechanical ventilation, although the significance of individual measures remains unclear [1]. We did not intend to investigate prognostic factors, and further prospective work is needed to help determine which cohort of patients may benefit most from mechanical ventilation (MV). (Source: Resp...
Source: Respiratory Medicine CME - May 31, 2016 Category: Respiratory Medicine Authors: Barret Rush, Katie Wiskar, Landon Berger, Donald Griesdale Source Type: research
Diagnostic value of (1 → 3)-β-D-glucan in bronchoalveolar lavage fluid for invasive fungal disease: A meta-analysis
The serum (1 → 3)-β-D-glucan (BG) assay has been approved for diagnosing invasive fungal diseases (IFDs). However, the performance of (1 → 3)-β-D-glucan assay in bronchoalveolar lavage (BAL) fluid is various among studies. The present study aimed to assess the accuracy of (1 → 3)-β-D-glucan assay in bronchoalveolar lavage fluid for the diagnosis of invasive fungal diseases by means of meta-analysis and systematic review of relevant studies. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 31, 2016 Category: Respiratory Medicine Authors: Xin-yu Shi, Yao Liu, Xian-min Gu, Sheng-yu Hao, Yu-hong Wang, Di Yan, Shu-juang Jiang Tags: Review article Source Type: research
Reply to Letter to the Editor - Capnometry in children with bronchiolitis: a pathophysiological point of view
We appreciate the comments and kind remarks by Jacopo et al in their letter, Capnometry in children with bronchiolitis: a pathophysiological point of view. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 31, 2016 Category: Respiratory Medicine Authors: Fahed Hakim, Ron Jacob, Lea Bentur Source Type: research
Reply to Letter to the Editor - Mechanical ventilation in idiopathic pulmonary fibrosis: Unresolved dilemma
We are grateful to Dr’s Santos et al. for their comments on our article. Indeed, a critical limitation of studies employing large databases is the lack of granular patient-level data. The character of the underlying disease and the severity of illness at presentation undoubtedly plays a role in determining a patient’s suitability for mechanical ventilation, although the significance of individual measures remains unclear.1 We did not intend to investigate prognostic factors, and further prospective work is needed to help determine which cohort of patients may benefit most from mechanical ventilation (MV). (Source: Resp...
Source: Respiratory Medicine CME - May 31, 2016 Category: Respiratory Medicine Authors: Barret Rush, Katie Wiskar, Landon Berger, Donald Griesdale Source Type: research
Nonspecific interstitial pneumonia preceding diagnosis of collagen vascular disease
The aim of this study was to evaluate the incidence and clinical features of patients who developed collagen vascular disease (CVD) after an initial diagnosis of idiopathic nonspecific interstitial pneumonia (NSIP). (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 31, 2016 Category: Respiratory Medicine Authors: Masato Kono, Yutaro Nakamura, Katsuhiro Yoshimura, Yasunori Enomoto, Yoshiyuki Oyama, Hironao Hozumi, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Etsuko Hamada, Thomas V. Colby, Masato Maekawa, Takafumi Suda Source Type: research
Undernutrition state in patients with chronic obstructive pulmonary disease. A critical appraisal on diagnostics and treatment
‘Undernutrition state’ (UNS) is an ominous condition, in particular when associated with chronic obstructive pulmonary disease (COPD). In this review we discuss pathophysiological mechanisms and how UNS is defined and diagnosed. It seems unlikely that COPD-patients with established UNS have similar potential of reversibility (treatability) upon nutrition interventions as patients at a risk of developing such a condition, i.e. patients with low energy/nutrient intake, since pathophysiological, biochemical and metabolic conditions may differ substantially. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 30, 2016 Category: Respiratory Medicine Authors: Gunnar Akner, Kjell Larsson Tags: Clinical trial paper Source Type: research
Can bronchial asthma with an highly prevalent airway (and systemic) vagal tone be considered an independent asthma phenotype? Possible role of anticholinergics
Recently, we studied occurrence and role of non-respiratory symptoms (n-RSs) before a worsening of asthma symptoms. Some n-RSs such as anxiety, reflux, heartburn abdominal pain, which appeared within 3 h before the onset of an asthma attack, are the likely result of an imbalance between sympathetic/parasympathetic systems with an increase in cholinergic tone. Therefore, it is likely that some of these n-RSs induced by the increased cholinergic tone might be present related with specific parasympathetic-associated respiratory symptoms such as those elicited by airway narrowing. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 30, 2016 Category: Respiratory Medicine Authors: Gennaro Liccardi, Antonello Salzillo, Luigino Calzetta, Mario Cazzola, Maria Gabriella Matera, Paola Rogliani Tags: Short review Source Type: research
Clinical characteristics of adult asthma associated with small airway dysfunction
Suboptimal asthma control is common despite modern asthma therapy. The degree of peripheral airway involvement remains unclear and poor medication delivery to these regions might be a contributing reason for this failure in obtaining adequate symptom control.A cohort of 196 adults (median (range) age 44 (18–61) years, 109 females, 54 ex-smokers, six current smokers) with physician-diagnosed asthma were recruited from primary care. Subjects were characterized clinically by interviews, questionnaires, skin prick tests (SPT) and blood eosinophil counts. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 30, 2016 Category: Respiratory Medicine Authors: S. Kjellberg, B.K. Houltz, O. Zetterström, P.D. Robinson, Per M. Gustafsson Source Type: research
The barriers to accessing primary care resulting in hospital presentation for exacerbation of asthma or chronic obstructive pulmonary disease in a large teaching hospital in London
This study aims to establish the pathway that patients undertake to access care in the lead up to an accident and emergency (A&E) attendance and/or inpatient admission. Patients attending A&E and/or following an inpatient admission due to an exacerbation of asthma or COPD were reviewed by a specialist respiratory pharmacist during weekday working hours. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 26, 2016 Category: Respiratory Medicine Authors: Marium Naqvi, Hasanin Khachi Source Type: research
Angiopoietin-2 expression in patients with an acute exacerbation of idiopathic interstitial pneumonias
We hypothesized that increased pulmonary vascular permeability may play a role in the pathogenesis of an acute exacerbation of the idiopathic interstitial pneumonias (AE-IIPs). Angiopoietin-2 (Ang-2) promotes endothelial activation, destabilization, and inflammation. The purpose of this study was to examine whether Ang-2 expression was associated with the pathogenesis of AE-IIPs. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 23, 2016 Category: Respiratory Medicine Authors: Masaru Ando, Eishi Miyazaki, Tetsutaro Abe, Chihiro Ehara, Akihiro Goto, Taiki Masuda, Suehiro Nishio, Hideaki Fujisaki, Mari Yamasue, Toshihiro Ishii, Yutaka Mukai, Takeo Ito, Shin-ich Nureki, Toshihide Kumamoto, Junichi Kadota Source Type: research
