Inflammatory markers predict episodes of wheezing during the first year of life in Bangladesh
Environmental factors that influence wheezing in early childhood in the developing world are not well understood and may be useful in predicting respiratory outcomes. Therefore, our objective was to determine the factors that can predict wheezing. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - November 20, 2015 Category: Respiratory Medicine Authors: Stacey L. Burgess, Miao Lu, Jennie Z. Ma, Caitlin Naylor, Jeffrey R. Donowitz, Beth D. Kirkpatrick, Rashidul Haque, William A. Petri Source Type: research
A retrospective pilot study examining the use of Acthar gel in sarcoidosis patients
Acthar was reported as effective for the treatment of pulmonary sarcoidosis in the 1950s. Use of drug waned due to cost and toxicity compared to prednisone. Recent interest has reemerged as an alternative to high dose oral glucocorticoids. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - November 18, 2015 Category: Respiratory Medicine Authors: Robert P. Baughman, Joseph B. Barney, Lanier O’Hare, Elyse E. Lower Source Type: research
Respiratory symptoms/diseases prevalence is still increasing: a 25-yr population study
few epidemiological surveys on general population samples estimated changes in prevalence of respiratory symptoms/diseases over a long time interval; our study aims to quantify the temporal changes in the prevalence rates of asthma, allergic rhinitis and Chronic Obstructive Pulmonary Disease (COPD) after 25 years from baseline. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - November 13, 2015 Category: Respiratory Medicine Authors: Sara Maio, Sandra Baldacci, Laura Carrozzi, Francesco Pistelli, Mrs. Anna Angino, Marzia Simoni, Giuseppe Sarno, Sonia Cerrai, Franca Martini, Martina Fresta, Patrizia Silvi, Francesco Di Pede, Massimo Guerriero, Giovanni Viegi Source Type: research
Differences between absolute and predicted values of forced expiratory volumes to classify ventilatory impairment in chronic obstructive pulmonary disease
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) severity criterion for COPD is used widely in clinical and research settings; however, it requires the use of ethnic- or population-specific reference equations. We propose two alternative severity criteria based on absolute post-bronchodilator FEV1 values (FEV1 and FEV1/height2) that do not depend on reference equations. We compared the accuracy of these classification schemas versus those on % predicted values (GOLD criterion) and Z-scores of post-bronchodilator FEV1 to predict COPD-related functional outcomes or percent emphysema by computerized tomograph...
Source: Respiratory Medicine CME - November 11, 2015 Category: Respiratory Medicine Authors: William Checkley, Marilyn G. Foreman, Surya Bhatt, Mark Dransfield, MeiLan Han, Nicola A. Hanania, Nadia N. Hansel, Elizabeth A. Regan, Robert A. Wise, COPDGene Study Investigators Source Type: research
Acinar ventilation heterogeneity in COPD relates to diffusion capacity, resistance and reactance
The aim of this study was to investigate heterogenic ventilation in the acinar (Sacin) and conductive (Scond) airways of patients with varying chronic obstructive pulmonary disease (COPD) severity and how these relates to advanced lung function parameters, primarily measured by impulse oscillometry (IOS). A secondary aim was to investigate the effects of a short acting beta2-agonist and a muscarinic antagonist on the heterogenic ventilation.Eleven never smoking controls, 12 smoking controls, and 57 COPD patients (7 GOLD 1, 25 GOLD 2, 14 GOLD 3 and 11 GOLD 4) performed flow-volume spirometry, IOS, body plethysmography, sing...
Source: Respiratory Medicine CME - November 11, 2015 Category: Respiratory Medicine Authors: Linnea Jarenbäck, Jaro Ankerst, Leif Bjermer, Ellen Tufvesson Source Type: research
Association of polycyclic aromatic hydrocarbons and asthma among children 6–19 years: NHANES 2001–2008 and NHANES 2011–2012
This study investigated the association of urinary PAHs with asthma in U.S. children. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - November 9, 2015 Category: Respiratory Medicine Authors: Hui Liu, Cheng Xu, Zhao-Yan Jiang, Aihua Gu Source Type: research
Association of Polycyclic aromatic hydrocarbons and Asthma among children 6-19 years: NHANES 2001-2008 and NHANES 2011-2012
This study investigated the association of urinary PAHs with asthma in U.S. children. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - November 9, 2015 Category: Respiratory Medicine Authors: Hui Liu, Cheng Xu, Zhao-Yan Jiang, Aihua Gu Source Type: research
Association of Early Suspected Acute Exacerbations of Idiopathic Pulmonary Fibrosis with Subsequent Clinical Outcomes and Healthcare Resource Utilization
This study quantified the association between occurrence of suspected acute exacerbations of IPF (AEx-IPF) in the 6 months post-IPF diagnosis with clinical outcomes and IPF-related healthcare resource utilization (HRU). (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - November 5, 2015 Category: Respiratory Medicine Authors: Yanni F. Yu, Dendy S. Macaulay, William M. Reichmann, Eric Q. Wu, Steven D. Nathan Source Type: research
Achieving asthma control with ICS/LABA: A review of strategies for asthma management and prevention
Maintenance treatment with an inhaled corticosteroid (ICS) and a long-acting β2-agonist (LABA) is recommended for patients whose asthma is not controlled with a low-to-moderate dose of ICS alone; a separate reliever medication is used on an as-needed basis. The Gaining Optimal Asthma ControL (GOAL) study demonstrated that salmeterol/fluticasone maintenance treatment can improve asthma control and reduce future risk compared with fluticasone alone, although the dose escalation design of this study meant that most patients treated with salmeterol/fluticasone were receiving the highest dose of ICS at the end of the study. (S...
Source: Respiratory Medicine CME - November 5, 2015 Category: Respiratory Medicine Authors: René Aalbers, Claus Vogelmeier, Piotr Kuna Tags: Review article Source Type: research
Prevalence and underdiagnosis of airway obstruction among middle-aged adults in northern France: the ELISABET study 2011-2013
This study was designed to calculate the prevalence AO among middle-aged adults in northern France, explore the associated risk factors and evaluate the underdiagnosis. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - November 3, 2015 Category: Respiratory Medicine Authors: Alexandre Quach, Jonathan Giovannelli, Natalie Chérot-Kornobis, Alina Ciuchete, Guillaume Clément, Régis Matran, Philippe Amouyel, Jean-Louis Edmé, Luc Dauchet Source Type: research
Guidance on handheld inhalers in asthma and COPD guidelines: An update
Historically, guidance on inhalation devices has been lacking in international and national asthma/COPD guidelines. A previous review of recommendations in Global Initiative for Asthma (GINA) 2012 (1) and Global initiative for chronic Obstructive Lung Disease (GOLD) 2011 (2) international guidelines revealed that the proportion of specific device-related content was extremely limited, comprising (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - November 3, 2015 Category: Respiratory Medicine Authors: P.N. Richard Dekhuijzen Tags: Correspondence Source Type: research
Association of pulse wave velocity with total lung capacity: A cross-sectional analysis of the BOLD London study
Low lung function, measured using spirometry, has been associated with mortality from cardiovascular disease, but whether this is explained by airflow obstruction or restriction is a question that remains unanswered. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - November 2, 2015 Category: Respiratory Medicine Authors: André F.S. Amaral, Jaymini Patel, Louisa Gnatiuc, Meinir Jones, Peter G.J. Burney Source Type: research
Medically Treated Exacerbations in COPD by GOLD 1-4: A Valid, Robust, and Seemingly Low-Biased Definition
We hypothesized that medically treated exacerbations in COPD defined as treatments with oral corticosteroids alone or in combination with antibiotics by register linkage with a nationwide prescription registry is a valid, robust and low-biased measure of exacerbations. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 31, 2015 Category: Respiratory Medicine Authors: Truls S. Ingebrigtsen, Jacob L. Marott, Peter Lange, Jesper Hallas, Børge G. Nordestgaard, Jørgen Vestbo Source Type: research
Effects of doxycycline on local and systemic inflammation in stable COPD patients, a randomized clinical trial
Neutrophilic inflammation plays a causal role in Chronic Obstructive Pulmonary Disease (COPD). Neutrophil derived myeloperoxidase(MPO) matrix metalloproteinases(MMP’s), and elastases are thought to contribute to the perpetuation of the disease. The tetracycline analogue doxycycline has been shown to inhibit neutrophil-mediated inflammation. It was thus reasoned that doxycycline may attenuate neutrophil-mediated inflammation in COPD. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 29, 2015 Category: Respiratory Medicine Authors: Hendrik J. Prins, Johannes Daniels, Jan H. Lindeman, René Lutter, Wim G. Boersma Source Type: research
IgE-mediated asthma: new revelations and future insights
IgE has a central role in the pathogenesis of allergic asthma; the importance of the IgE-mediated immunoregulatory effects of dendritic cells in driving Th2 inflammatory responses has been demonstrated.1 Omalizumab, an anti-IgE antibody, may inhibit the whole allergic cascade, preventing early and late phases of the allergic response.2 Clinicaltrial data have shown a significant reduction in severe allergic asthma exacerbation rates (-59% vs control, p (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 29, 2015 Category: Respiratory Medicine Authors: Ratko Djukanovic, Nicola Hanania, William Busse, David Price Tags: Short communication Source Type: research
