IgE-mediated asthma: new revelations and future insights

IgE has a central role in the pathogenesis of allergic asthma; the importance of the IgE-mediated immunoregulatory effects of dendritic cells in driving Th2 inflammatory responses has been demonstrated.1 Omalizumab, an anti-IgE antibody, may inhibit the whole allergic cascade, preventing early and late phases of the allergic response.2 Clinicaltrial data have shown a significant reduction in severe allergic asthma exacerbation rates (-59% vs control, p
Source: Respiratory Medicine CME - Category: Respiratory Medicine Authors: Tags: Short communication Source Type: research