Effects of doxycycline on local and systemic inflammation in stable COPD patients, a randomized clinical trial

Neutrophilic inflammation plays a causal role in Chronic Obstructive Pulmonary Disease (COPD). Neutrophil derived myeloperoxidase(MPO) matrix metalloproteinases(MMP’s), and elastases are thought to contribute to the perpetuation of the disease. The tetracycline analogue doxycycline has been shown to inhibit neutrophil-mediated inflammation. It was thus reasoned that doxycycline may attenuate neutrophil-mediated inflammation in COPD.

Source: Respiratory Medicine CME - October 29, 2015 Category: Respiratory Medicine Authors: Hendrik J. Prins, Johannes Daniels, Jan H. Lindeman, René Lutter, Wim G. Boersma Source Type: research