Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma
Asthma in the elderly as well as asthma of adult-onset has been associated with increased morbidity, but little is known specifically about the effects of age on clinical and inflammatory outcomes in severe refractory asthma. The aims of the study were to examine the effects of age [ < 65 versus ≥65 years] and age of onset of asthma [childhood-onset, < 18 versus adult-onset, ≥18 years] on clinical and inflammatory variables in patients with severe asthma. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 7, 2016 Category: Respiratory Medicine Authors: Rekha Chaudhuri, Charles McSharry, Liam G. Heaney, Robert Niven, Christopher E. Brightling, Andrew N. Menzies-Gow, Christine Bucknall, Adel H. Mansur, Waiting Lee, Malcolm Shepherd, Mark Spears, Douglas C. Cowan, Holger Husi, Neil C. Thomson, on behalf of Source Type: research
Population-based weight loss and gain do not explain trends in asthma mortality in Cuba: A prospective study from 1964 to 2014
The increase in prevalence of obesity is a possible risk factor for asthma in developed countries. As the people of Cuba experienced an acute population-based decrease in weight in the 1990s, we tested the hypothesis that national weight loss and subsequent weight gain was associated a reciprocal changes in asthma mortality. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 7, 2016 Category: Respiratory Medicine Authors: Ramón Suárez-Medina, Silvia Josefina Venero-Fernández, John Britton, Andrew W. Fogarty Tags: Short communication Source Type: research
Nonsteroidal anti-inflammatory drug (NSAID) exacerbated respiratory disease phenotype: Topical NSAID and asthma control – A possible oversight link
Patients with aspirin-exacerbated respiratory disease (AERD) also recently known as nonsteroidal anti-inflammatory drug (NSAID) exacerbated respiratory disease (NERD) must avoid aspirin and all other oral NSAIDs. The effect of topical NSAID (tNSAID), especially salicylates which are commonly present in topical medicated preparations, on asthma control of this phenotype is studied. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 7, 2016 Category: Respiratory Medicine Authors: Jessica Han Ying Tan, Anne Ann Ling Hsu Tags: Short communication Source Type: research
Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma
Asthma in the elderly as well as asthma of adult-onset has been associated with increased morbidity, but little is known specifically about the effects of age on clinical and inflammatory outcomes in severe refractory asthma. The aims of the study were to examine the effects of age [ (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 7, 2016 Category: Respiratory Medicine Authors: Rekha Chaudhuri, Charles McSharry, Liam G. Heaney, Robert Niven, Christopher E. Brightling, Andrew N. Menzies-Gow, Christine Bucknall, Adel H. Mansur, Waiting Lee, Malcolm Shepherd, Mark Spears, Douglas C. Cowan, Holger Husi, Neil C. Thomson Source Type: research
Identification of five clusters of comorbidities in a longitudinal Japanese chronic obstructive pulmonary disease cohort
Patients with chronic obstructive pulmonary disease (COPD) frequently suffer from various comorbidities. Recently, cluster analysis has been proposed to examine the phenotypic heterogeneity in COPD. In order to comprehensively understand the comorbidities of COPD in Japan, we conducted multicenter, longitudinal cohort study, called the Keio COPD Comorbidity Research (K-CCR). In this cohort, comorbid diagnoses were established by both objective examination and review of clinical records, in addition to self-report. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 5, 2016 Category: Respiratory Medicine Authors: Shotaro Chubachi, Minako Sato, Naofumi Kameyama, Akihiro Tsutsumi, Mamoru Sasaki, Hiroki Tateno, Hidetoshi Nakamura, Koichiro Asano, Tomoko Betsuyaku, the Keio COPD Comorbidity Research (K-CCR) Group Source Type: research
Safety and tolerability of once-daily tiotropium Respimat ® as add-on to at least inhaled corticosteroids in adult patients with symptomatic asthma: A pooled safety analysis
Tiotropium, a long-acting anticholinergic bronchodilator, has demonstrated efficacy and safety as add-on therapy to inhaled corticosteroids (ICS), with or without other maintenance therapies, in patients with symptomatic asthma. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 3, 2016 Category: Respiratory Medicine Authors: Ronald Dahl, Michael Engel, Daniel Dusser, David Halpin, Huib A.M. Kerstjens, Liliana Zaremba-Pechmann, Petra Moroni-Zentgraf, William W. Busse, Eric D. Bateman Source Type: research
Safety and tolerability of once-daily tiotropium Respimat® as add-on to at least inhaled corticosteroids in adult patients with symptomatic asthma: A pooled safety analysis
Tiotropium, a long-acting anticholinergic bronchodilator, has demonstrated efficacy and safety as add-on therapy to inhaled corticosteroids (ICS), with or without other maintenance therapies, in patients with symptomatic asthma. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 3, 2016 Category: Respiratory Medicine Authors: Ronald Dahl, Michael Engel, Daniel Dusser, David Halpin, Huib A.M. Kerstjens, Liliana Zaremba-Pechmann, Petra Moroni-Zentgraf, William W. Busse, Eric D. Bateman Source Type: research
Enhanced LPS-induced activation of IL-27 signalling in sarcoidosis
Granulomas in sarcoidosis have recently been described as containing Interleukin (IL)-27, one of the members of the IL-12 family of cytokines, which also includes IL-35. Levels of these cytokines and the IL-27 receptor subunits were hypothesised to differ between patients with sarcoidosis compared to healthy controls in peripheral blood. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - June 30, 2016 Category: Respiratory Medicine Authors: Sabine Ringkowski, Joshua Loke, Shuying Huang, Hasib Ahmadzai, Felix J.F. Herth, Paul S. Thomas, Cristan Herbert Source Type: research
Impact of hyponatremia on mortality and morbidity in patients with COPD exacerbations
Hyponatremia is the most common electrolyte disorder in hospitalized patients, being associated with increased morbidity and mortality in different clinical conditions. However, the prevalence and impact of this electrolytic disorder in patients hospitalized for an exacerbation of COPD still remains unknown. The aim of the present study was to clarify these points. A total of 424 patients hospitalized due to a COPD exacerbation were consecutively included, showing a frequency of hyponatremia of 15.8% (hyposmolar in most cases). (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - June 28, 2016 Category: Respiratory Medicine Authors: Roberto Chalela, José Gregorio González-García, Juan José Chillarón, Leticia Valera-Hernández, Carlos Montoya-Rangel, Diana Badenes, Sergi Mojal, Joaquim Gea Source Type: research
Ambrisentan response in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) – A subgroup analysis of the ARIES-E clinical trial
Pulmonary arterial hypertension (PAH) is a condition which may lead to right ventricular failure and early mortality and is an important complication in patients with connective tissue disease (CTD). Previously, the endothelin A selective receptor antagonist, ambrisentan, demonstrated efficacy and safety in treating patients with PAH due to WHO Group I etiologies. These analyses describe the 3-year efficacy and safety of ambrisentan in patients specifically with CTD associated PAH (CTD-PAH). (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - June 28, 2016 Category: Respiratory Medicine Authors: Aryeh Fischer, Christopher P. Denton, Marco Matucci-Cerinic, Hunter Gillies, Christiana Blair, James Tislow, Steven D. Nathan Source Type: research
Healthcare burden of obstructive sleep apnea and obesity among asthma hospitalizations: Results from the U.S.-based Nationwide Inpatient Sample
Studies have highlighted the significant comorbidities of both obesity and obstructive sleep apnea (OSA) among asthma patients in outpatient settings, but such data in the inpatient setting is sparse. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - June 26, 2016 Category: Respiratory Medicine Authors: Monideepa B. Becerra, Benjamin J. Becerra, Mihaela Teodorescu Tags: Clinical trial paper Source Type: research
Women using bleach for home cleaning are at increased risk of non-allergic asthma
Bleach is widely used for household cleaning. Although it is recognized that occupational use of bleach may have adverse respiratory health effects, it is unknown whether common domestic use of bleach may be a risk factor for asthma. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - June 24, 2016 Category: Respiratory Medicine Authors: Bobette Matulonga, Marta Rava, Valérie Siroux, Alfred Bernard, Orianne Dumas, Isabelle Pin, Jan-Paul Zock, Rachel Nadif, Bénédicte Leynaert, Nicole Le Moual Source Type: research
A 12-year prognosis of adult-onset asthma: Seinäjoki Adult Asthma Study
Long-term prognosis of adult-onset asthma is poorly known. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - June 22, 2016 Category: Respiratory Medicine Authors: Leena E. Tuomisto, Pinja Ilmarinen, Onni Niemelä, Jussi Haanpää, Terhi Kankaanranta, Hannu Kankaanranta Source Type: research
A 12-year prognosis of adult-onset asthma:Seinäjoki Adult Asthma Study
Long-term prognosis of adult-onset asthma is poorly known. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - June 22, 2016 Category: Respiratory Medicine Authors: Leena E. Tuomisto, Pinja Ilmarinen, Onni Niemelä, Jussi Haanpää, Terhi Kankaanranta, Hannu Kankaanranta Source Type: research
