Increased levels of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein in idiopathic pulmonary fibrosis

Mac-2 binding protein (M2BP) is a cell-adhesive glycoprotein of the extracellular matrix secreted as a ligand of galectin-3 (Mac-2). Recently, a Wisteria floribunda agglutinin positive-M2BP (WFA+-M2BP) assay developed using a lectin-antibody sandwich immunoassay has shown promise as a new fibrotic marker in liver fibrosis to detect unique fibrosis-related glycoalteration. The aim of this study is to evaluate the utility of serum WFA+-M2BP levels in patients with idiopathic pulmonary fibrosis (IPF).

Source: Respiratory Medicine CME - April 24, 2016 Category: Respiratory Medicine Authors: Masato Kono, Yutaro Nakamura, Yoshiyuki Oyama, Kazutaka Mori, Hironao Hozumi, Masato Karayama, Dai Hashimoto, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Masaomi Yamada, Etsuko Hamada, Thomas V. Colby, Masato Maekawa, Takafumi Suda Source Type: research