Histidine-rich glycoprotein and idiopathic pulmonary fibrosis

Histidine-rich glycoprotein (HRG) is an enigmatic glycoprotein able to interact with a variety of ligands such as IgG, complement components, heparan sulfate, thrombospondin, fibrinogen and plasminogen. HRG is present at high concentrations in plasma and there is evidence indicating that it is able to modulate the course of biological processes such as angiogenesis, fibroblast proliferation, complement activation, coagulation and fibrinolysis. Because these processes are involved in the pathogeneses of lung fibrosis we here analyzed a possible link between HRG and idiopathic pulmonary fibrosis (IPF).

Source: Respiratory Medicine CME - October 27, 2015 Category: Respiratory Medicine Authors: G. Ernst, E. Dantas, J. Sabatté, F. Caro, A. Salvado, P. Grynblat, J. Geffner Tags: Short communication Source Type: research