Changes in intestinal immunity, gut microbiota and expression of energy metabolism-related genes explain adenoma growth in bilberry and cloudberry-fed ApcMin mice
We showed previously that ellagitannin-rich cloudberries and anthocyanin-rich bilberries reduce the number of intestinal adenomas in multiple intestinal neoplasia/+ (ApcMin) mice. We also found that cloudberries decreased the size of adenomas, while bilberries increased it. Here we hypothesized that the difference in adenoma growth could be explained by dissimilar effects of the berries on intestinal immune responses and gut microbiota, potentially driven by the distinct polyphenol compositions of the two berries. (Source: Nutrition Research)
Source: Nutrition Research - October 14, 2016 Category: Nutrition Authors: Essi P äivärinta, Mikael Niku, Johanna Maukonen, Markus Storvik, Anu Heiman-Lindh, Maria Saarela, Anne-Maria Pajari, Marja Mutanen Tags: Original Research Source Type: research
Menaquinone-4 (vitamin K2) up-regulates expression of human intestinal alkaline phosphatase in Caco-2 cells
Alkaline phosphatase (ALP) hydrolyzes several monophosphate esters into inorganic acid and alcohol. In humans, four kinds of ALP isozymes have been identified: tissue-nonspecific ALP, intestinal ALP, placental ALP, and germ cell ALP. Intestinal ALP is expressed at a high concentration in the brush border membrane of intestinal epithelial cells, and is known to be affected by several kinds of nutrients, such as lipids, but the physiological function of intestinal ALP has remained elusive. Vitamin K is an essential cofactor for the post-translational carboxylation of glutamate residues into gamma-carboxy glutamate. (Source: Nutrition Research)
Source: Nutrition Research - October 13, 2016 Category: Nutrition Authors: Seiko Noda, Asako Yamada, Rieko Tanabe, Kanae Nakaoka, Takayuki Hosoi, Masae Goseki-Sone Tags: Nutrition Research Source Type: research
Hyperglycemia, oxidative stress, liver damage and dysfunction in alloxan-induced diabetic rat are prevented by Spirulina supplementation
Medicinal plants have long been used against life-threatening diseases including diabetes, with more or less success. Some of these plants have been shown to possess antioxidant activities, which could help improving diabetes inconveniences. In that context, we investigated the effects of spirulina supplementation on alloxan-induced diabetic rats, hypothesizing that co-administration of spirulina with rat diet could ameliorate diabetes complications and provide as benefits as the common antidiabetic insulin. (Source: Nutrition Research)
Source: Nutrition Research - October 3, 2016 Category: Nutrition Authors: Manel Gargouri, Christian Magn é, Abdelfattah El Feki Source Type: research
Inhibition on the growth of human MDA-MB-231 breast cancer cells in vitro and tumor growth in a mouse xenograft model by Se-containing polysaccharides from Pyracantha fortuneana
This study aimed to assess the anticancer effect of Se-containing polysaccharides from P. (Source: Nutrition Research)
Source: Nutrition Research - October 1, 2016 Category: Nutrition Authors: Chengfu Yuan, Changdong Wang, Junjie Wang, Vikas Kumar, Firoz Anwar, Fangxiang Xiao, Gohar Mushtaq, Yufei Liu, Mohammad Amjad Kamal, Ding Yuan Source Type: research
Actinidia arguta supplementation protects aorta and liver in rats with induced hypercholesterolemia
There are no published results focusing on the study of hardy kiwifruit as a supplementation to the atherogenic diet. We hypothesized that hardy kiwifruit (Actinidia arguta (A. arguta)) from Poland possess better pro-healthy action than two Asian varieties (Hayward and Bidan). We tested this hypothesis by measuring the metabolic reactions of rats loaded with 1% cholesterol and supplemented with 5% of hardy kiwifruit (A. arguta), Hayward, or Bidan in their diets. The experiment was performed on 71 male Wistar rats. (Source: Nutrition Research)
Source: Nutrition Research - September 29, 2016 Category: Nutrition Authors: Maria Leontowicz, Hanna Leontowicz, Iwona Jesion, Wojciech Bielecki, Katarzyna Najman, Piotr Latocha, Yong-Seo Park, Shela Gorinstein Source Type: research
Kiwifruit Actinidia arguta supplementation protects aorta and liver in rats with induced hypercholesterolemia
There are no published results focusing on the study of hardy kiwifruit as a supplementation to the atherogenic diet. We hypothesized that hardy kiwifruit (Actinidia arguta (A. arguta)) from Poland possess better pro-healthy action than two Asian varieties (Hayward and Bidan). We tested this hypothesis by measuring the metabolic reactions of rats loaded with 1% cholesterol and supplemented with 5% of hardy kiwifruit (A. arguta), Hayward, or Bidan in their diets. The experiment was performed on 71 male Wistar rats. (Source: Nutrition Research)
Source: Nutrition Research - September 29, 2016 Category: Nutrition Authors: Maria Leontowicz, Hanna Leontowicz, Iwona Jesion, Wojciech Bielecki, Katarzyna Najman, Piotr Latocha, Yong-Seo Park, Shela Gorinstein Source Type: research
Maternal fat-soluble vitamins, brain development, and regulation of feeding behavior: an overview of research
Recent research shows a link between vitamin intake during pregnancy and offspring health. Inadequate intakes of water-soluble vitamins during pregnancy lead to obesity and characteristics of the metabolic syndrome, concurrent with altered developments in food intake regulatory pathways. Few studies, however, have reported on the effects of fat-soluble vitamins (A, D, E, and K) on the development of food intake regulatory pathways. The majority of studies to date have focused on associations between inadequate and high intakes of folic acid and vitamin D and neurocognitive development of the offspring. (Source: Nutrition Research)
Source: Nutrition Research - September 16, 2016 Category: Nutrition Authors: Diana S ánchez-Hernández, G. Harvey Anderson, Abraham N. Poon, Emanuela Pannia, Clara E. Cho, Pedro S.P. Huot, Ruslan Kubant Tags: Review Source Type: research
Maternal fat-soluble vitamins, brain development and regulation of feeding behavior: an overview of research
Recent research shows a link between vitamin intake during pregnancy and offspring health. Inadequate intakes of water soluble vitamins during pregnancy lead to obesity and characteristics of the metabolic syndrome, concurrent with altered developments in food intake regulatory pathways. Few studies, however, have reported on the effects of fat-soluble vitamins (A, D, E and K) on the development of food intake regulatory pathways. The majority of studies to date have focused on associations between inadequate and high intakes of folic acid and vitamin D and neurocognitive development of the offspring. (Source: Nutrition Research)
Source: Nutrition Research - September 16, 2016 Category: Nutrition Authors: Diana S ánchez-Hernández, G. Harvey Anderson, Abraham N. Poon, Emanuela Pannia, Clara E. Cho, Pedro S.P. Huot, Ruslan Kubant Tags: Review Source Type: research
Quercetin relaxes guinea pig gallbladder strips
Quercetin, a phytoestrogen and flavonoid, relaxes intestinal and vascular smooth muscle. The purpose of this study was to determine if quercetin had an effect on gallbladder smooth muscle. An in vitro technique was used to determine the effects of quercetin on gallbladder strips and which system(s) mediated the relaxation. Paired t-tests were used; differences between means of P (Source: Nutrition Research)
Source: Nutrition Research - September 15, 2016 Category: Nutrition Authors: Loren Kline, Edward Karpinski Tags: Original Research Source Type: research
Lutein and zeaxanthin supplied by red/orange foods and fruits are more closely associated with macular pigment optical density than those from green vegetables in Spanish subjects
Lutein and zeaxanthin (L+Z) accumulate in the retina. Although vegetables are major contributors to their intake, a stronger association between fruits and macular pigment optical density (MPOD) has been reported. We hypothesized that L+Z intake from fruits would have a stronger association with L+Z status markers (MPOD, serum concentrations) than intake from vegetables or eggs, and that those associations would also differ according to plant foods color. One hundred eight subjects (57 men; age groups, 20-35 and 45-65 years) were enrolled in a cross-sectional study. (Source: Nutrition Research)
Source: Nutrition Research - September 13, 2016 Category: Nutrition Authors: Roc ío Estévez-Santiago, Begoña Olmedilla-Alonso, Beatriz Beltrán-de-Miguel, Carmen Cuadrado-Vives Tags: Original Research Source Type: research
Consumption of chokeberry (Aronia mitschurinii) products modestly lowered blood pressure and reduced low-grade inflammation in subjects with mildly elevated blood pressure
Previous studies suggest that consumption of chokeberries may improve cardiovascular disease risk factor profiles. We hypothesized that chokeberries (Aronia mitschurinii) have beneficial effects on blood pressure, low-grade inflammation, serum lipids, serum glucose, and platelet aggregation in subjects with untreated mild hypertension. Totally 38 subjects were enrolled into a 16-wk. single blinded crossover trial. The subjects were randomized to use cold-pressed 100% chokeberry juice (300 ml/day) and oven-dried chokeberry powder (3 g/day) or matched placebo products in random order for 8 weeks each with no washout period. ...
Source: Nutrition Research - September 13, 2016 Category: Nutrition Authors: Britt-Marie Loo, Iris Erlund, Raika Koli, Pauli Puukka, Jarkko Hellstr öm, Kristiina Wähälä, Pirjo Mattila, Antti Jula Tags: Original Research Source Type: research
Lutein and zeaxanthin supplied by red /orange foods and fruits are more closely associated with macular pigment optical density than those from green vegetables in Spanish subjects
Lutein and zeaxanthin (L+Z) accumulate in the retina. Although vegetables are major contributors to their intake, a stronger association between fruit and macular pigment optical density (MPOD) has been reported. We hypothesized that L+Z intake from fruits would have a stronger association with L+Z status markers (MPOD, serum concentrations) than intake from vegetables or eggs and, that those associations would also differ according to plant foods color. 108 subjects (57 men)(20 –35, 45-65y) were enrolled in a cross-sectional study. (Source: Nutrition Research)
Source: Nutrition Research - September 13, 2016 Category: Nutrition Authors: Roc ío Estévez-Santiago, B. Olmedilla-Alonso, B. Beltrán-de-Miguel, C. Cuadrado-Vives Tags: Original Research Source Type: research
Panaxatriol derived from ginseng augments resistance exercised –induced protein synthesis via mTORC1 signaling in rat skeletal muscle
Resistance exercise activates muscle protein synthesis via the mammalian target of rapamycin complex 1 (mTORC1) pathway and subsequent muscle hypertrophy. Upstream components of the mTORC1 pathway are widely known to be involved in Akt and extracellular signal –regulated kinase 1/2 (ERK1/2) signaling. Previous studies have shown that ginseng stimulated Akt and ERK1/2 signaling. Therefore, we hypothesized that panaxatriol (PT) derived from ginseng triggers mTORC1 signaling and muscle protein synthesis by activating both the Akt and ERK1/2 signaling pathw ays, and that PT additively stimulates muscle protein synthesis when...
Source: Nutrition Research - September 12, 2016 Category: Nutrition Authors: Yusuke Takamura, Yuhei Makanae, Satoru Ato, Naomi Yoshii, Kohei Kido, Mitsuru Nomura, Akira Uchiyama, Naruhiro Shiozawa, Satoshi Fujita Tags: Original Research Source Type: research
The fruit of Acanthopanax senticosus (Rupr. et Maxim.) Harms improves insulin resistance and hepatic lipid accumulation by modulation of liver adenosine monophosphate –activated protein kinase activity and lipogenic gene expression in high-fat diet–fed obese mice
Obesity-associated insulin resistance is a major risk factor for most metabolic diseases, including dyslipidemia and type 2 diabetes. Acanthopanax senticosus (Rupr. et Maxim.) Harms (Goka) root has been used in traditional Chinese medicine for treatment of diabetes and other conditions; however, little is known about the effects of Goka fruit (GF). Goka fruit is rich in anthocyanin, which has beneficial effects on obesity and insulin resistance via activation of adenosine monophosphate –activated protein kinase (AMPK). (Source: Nutrition Research)
Source: Nutrition Research - September 12, 2016 Category: Nutrition Authors: Tetsuo Saito, Miyako Nishida, Masafumi Saito, Akari Tanabe, Takahiro Eitsuka, Shi-Hua Yuan, Nobuo Ikekawa, Hiroshi Nishida Tags: Original Research Source Type: research
Panaxatriol derived from ginseng augments resistance exercised-induced protein synthesis via mTORC1 signaling in rat skeletal muscle
Resistance exercise activates muscle protein synthesis via the mammalian target of rapamycin complex 1 (mTORC1) pathway and subsequent muscle hypertrophy. Upstream components of the mTORC1 pathway are widely known to be involved in Akt and ERK1/2 signaling. Previous studies have shown that ginseng stimulated Akt and ERK1/2 signaling. Therefore, we hypothesized that panaxatriol (PT) derived from ginseng triggers mTORC1 signaling and muscle protein synthesis by activating both the Akt and ERK1/2 signaling pathways, and that PT additively stimulates muscle protein synthesis when combined with resistance exercise. (Source: Nutrition Research)
Source: Nutrition Research - September 12, 2016 Category: Nutrition Authors: Yusuke Takamura, Yuhei Makanae, Satoru Ato, Naomi Yoshii, Kohei Kido, Mitsuru Nomura, Akira Uchiyama, Naruhiro Shiozawa, Satoshi Fujita Tags: Original Research Source Type: research
