Maintenance of Cytosolic Calcium is Crucial to Extend L-Arginine Therapeutic Benefits During Continuous Dosing
The therapeutic benefits associated with short-term L-Arginine supplementation are lost during continuous dosing. AMP-activated protein kinase (AMPK) functional modulation has been correlated with L-Arginine therapeutic effectiveness, and with tolerance development during continuous supplementation. However, the metabolic link that is responsible for AMPK functional modulation during continuous L-Arginine exposure is currently not known. To explore this, we incubated HUVECs for 7 days with 100 μM L-Arginine, in the presence or absence of other agents; and monitored their effects for eNOS function, and on tolerance sparing...
Source: Nutrition Research - July 20, 2016 Category: Nutrition Authors: Srinidi Mohan, Lisa Harding Tags: Communication Source Type: research
Obesogenic diets have deleterious effects on fat deposits irrespective of the nature of dietary carbohydrates in a Yucatan minipig model
The effects of digestible carbohydrates, fructose in particular, on the development of metabolic disturbances remain controversial. We explored the effects of prolonged consumption of high-fat diets differing in their carbohydrate source on fat deposits in the adult Yucatan minipig. Eighteen minipigs underwent CT-imaging and blood sampling before and after 8 weeks of three isocaloric high-fat diets with different carbohydrate sources (20% by weight for starch in the control diet, glucose or fructose, n=6 per diet). (Source: Nutrition Research)
Source: Nutrition Research - July 20, 2016 Category: Nutrition Authors: Melissa Ochoa, David Val-Laillet, Jean-Paul Lall ès, Paul Meurice, Charles-Henri Malbert Tags: Original Research Source Type: research
Maintenance of Cytosolic Calcium is Crucial to Extend L-Arginine Therapeutic Benefits During Continuous Dosing
The therapeutic benefits associated with short-term L-Arginine supplementation are lost during continuous dosing. AMP-activated protein kinase (AMPK) functional modulation has been correlated with L-Arginine therapeutic effectiveness, and with tolerance development during continuous supplementation. However, the metabolic link that is responsible for AMPK functional modulation during continuous L-Arginine exposure is currently not known. To explore this, we incubated HUVECs for 7 days with 100 μM L-Arginine, in the presence or absence of other agents; and monitored their effects for eNOS function, and on tolerance sparing...
Source: Nutrition Research - July 20, 2016 Category: Nutrition Authors: Srinidi Mohan, Lisa Harding Tags: Communication Source Type: research
Obesogenic diets have deleterious effects on fat deposits irrespective of the nature of dietary carbohydrates in a Yucatan minipig model
The effects of digestible carbohydrates, fructose in particular, on the development of metabolic disturbances remain controversial. We explored the effects of prolonged consumption of high-fat diets differing in their carbohydrate source on fat deposits in the adult Yucatan minipig. Eighteen minipigs underwent CT-imaging and blood sampling before and after 8 weeks of three isocaloric high-fat diets with different carbohydrate sources (20% by weight for starch in the control diet, glucose or fructose, n=6 per diet). (Source: Nutrition Research)
Source: Nutrition Research - July 20, 2016 Category: Nutrition Authors: Melissa Ochoa, David Val-Laillet, Jean-Paul Lall ès, Paul Meurice, Charles-Henri Malbert Tags: Original Research Source Type: research
Exercise raises high-density lipoprotein cholesterol in men after consumption of ground beef with a high but not low monounsaturated fatty acid –saturated fatty acid ratio
Exercise and diets with higher monounsaturated fatty acid (MUFA):saturated fatty acid (SFA) ratios are independently linked to improved blood lipid profiles, yet interactive effects in men have not been studied. We hypothesized that dietary ground beef with a high MUFA:SFA ratio (HR = 1.1) would augment the beneficial changes in the lipid profile induced by exercise compared to dietary ground beef with a lower MUFA:SFA ratio (LR = 0.71). Untrained men (n = 13, age = 35 ± 12 y, weight = 91.4 ± 14.2 kg, body mass index = 27.8 ± 3.3kg/m2) consumed 5 HR or LR 114 g ground beef patties weekly for 5 weeks (random order) inter...
Source: Nutrition Research - June 27, 2016 Category: Nutrition Authors: Stephen F. Crouse, John S. Green, Thomas H. Meade, Dana R. Smith, Stephen B. Smith Tags: Original Research Source Type: research
Maternal high fructose and low protein consumption during pregnancy and lactation share some but not all effects on early-life growth and metabolic programming of rat offspring
The objective of this study was to characterize and compare the fetal programming effects of maternal fructose with the established programming model of a low-protein diet on offspring. (Source: Nutrition Research)
Source: Nutrition Research - June 27, 2016 Category: Nutrition Authors: Emily J. Arentson-Lantz, Mi Zou, Dorothy Teegarden, Kimberly K. Buhman, Shawn S. Donkin Tags: Original Research Source Type: research
Red blood cell oleic acid levels reflect olive oil intake while omega-3 levels reflect fish intake and the use of omega-3 acid ethyl esters: the GISSI-Heart Failure Trial
The GISSI-Heart Failure (HF) study reported benefits of n-3 fatty acid (FA) treatment on cardiovascular (CV) events, but the effects of treatment on a putative CV disease risk factor, the red blood cell (RBC) n-3 FA level (the omega-3 index), have not been examined in this context. We hypothesized that treatment with prescription omega-3 acid ethyl esters (O3AEE) would increase the omega-3 index to the proposed cardioprotective value of 8%. RBCs were collected from a subset of patients participating in the GISSI-HF study (n=461 out of 6975 randomized), at baseline and after 3 months of treatment with either an olive oil pl...
Source: Nutrition Research - June 27, 2016 Category: Nutrition Authors: William S. Harris, Serge Masson, Simona Barlera, Valentina Milani, Silvana Pileggi, Maria Grazia Franzosi, Roberto Marchioli, Gianni Tognoni, Luigi Tavazzi, Roberto Latini, G.I.S.S.I.-H.F. Investigators Source Type: research
Exercise raises HDL-C in men after consumption of ground beef with a high but not low MUFA:SFA ratio
Exercise and diets with higher MUFA:SFA ratios are independently linked to improved blood lipid profiles, yet interactive effects in men have not been studied. We hypothesized that dietary ground beef with a high MUFA:SFA ratio (HR=1.1) would augment the beneficial changes in the lipid profile induced by exercise compared to dietary ground beef with a lower MUFA:SFA ratio (LR=0.71). Untrained men (n=13, age=35 ±12 y, weight=91.4±14.2 kg, body mass index (BMI)=27.8±3.3kg/m2) consumed 5 HR or LR 114 g ground beef patties weekly for 5 wk. (Source: Nutrition Research)
Source: Nutrition Research - June 27, 2016 Category: Nutrition Authors: Stephen F. Crouse, John S. Green, Thomas H. Meade, Dana R. Smith, Stephen B. Smith Tags: Original Research Source Type: research
Maternal high fructose and low-protein consumption during pregnancy and lactation share some but not all effects on early-life growth and metabolic programming of rat offspring
The objective of this study was to characterize and compare the fetal programming effects of maternal fructose with the established programming model of a low protein diet on offspring. (Source: Nutrition Research)
Source: Nutrition Research - June 27, 2016 Category: Nutrition Authors: Emily J. Arentson-Lantz, Mi Zou, Dorothy Teegarden, Kimberly K. Buhman, Shawn S. Donkin Tags: Original Research Source Type: research
Red blood cell oleic acid levels reflect olive oil intake while omega-3 levels reflect fish intake and the use of omega-3 acid ethyl esters: the GISSI-Heart Failure Trial
The GISSI-Heart Failure (HF) study reported benefits of n-3 fatty acid (FA) treatment on cardiovascular (CV) events, but the effects of treatment on a putative CV disease risk factor, the red blood cell (RBC) n-3 FA level (the omega-3 index), have not been examined in this context. We hypothesized that treatment with prescription omega-3 acid ethyl esters (O3AEE) would increase the omega-3 index to the proposed cardioprotective value of 8%. RBCs were collected from a subset of patients participating in the GISSI-HF study (n=461 out of 6975 randomized), at baseline and after 3 months of treatment with either an olive oil pl...
Source: Nutrition Research - June 27, 2016 Category: Nutrition Authors: William S. Harris, Serge Masson, Simona Barlera, Valentina Milani, Silvana Pileggi, Maria Grazia Franzosi, Roberto Marchioli, Gianni Tognoni, Luigi Tavazzi, Roberto Latini, G.I.S.S.I.-H.F. Investigators Source Type: research
Exercise raises HDL-C in men after consumption of ground beef with a high but not low MUFA:SFA ratio
Exercise and diets with higher MUFA:SFA ratios are independently linked to improved blood lipid profiles, yet interactive effects in men have not been studied. We hypothesized that dietary ground beef with a high MUFA:SFA ratio (HR=1.1) would augment the beneficial changes in the lipid profile induced by exercise compared to dietary ground beef with a lower MUFA:SFA ratio (LR=0.71). Untrained men (n=13, age=35±12 y, weight=91.4±14.2 kg, body mass index (BMI)=27.8±3.3kg/m2) consumed 5 HR or LR 114 g ground beef patties weekly for 5 wk. (Source: Nutrition Research)
Source: Nutrition Research - June 27, 2016 Category: Nutrition Authors: Stephen F. Crouse, John S. Green, Thomas H. Meade, Dana R. Smith, Stephen B. Smith Tags: Original Research Source Type: research
Maternal high fructose and low-protein consumption during pregnancy and lactation share some but not all effects on early-life growth and metabolic programming of rat offspring
The objective of this study was to characterize and compare the fetal programming effects of maternal fructose with the established programming model of a low protein diet on offspring. (Source: Nutrition Research)
Source: Nutrition Research - June 27, 2016 Category: Nutrition Authors: Emily J. Arentson-Lantz, Mi Zou, Dorothy Teegarden, Kimberly K. Buhman, Shawn S. Donkin Tags: Original Research Source Type: research
Twice weekly intake of farmed Atlantic salmon (Salmo salar) positively influences lipoprotein concentration and particle size in overweight men and women
The U.S. Dietary Guidelines for Americans recommend twice weekly fish intake. Farmed Atlantic salmon is a good source of omega-3 (n-3) fatty acids which have positive lipid modifying effects; however, it is unknown whether these responses are dose-dependent. Our primary research objective was to determine the effect of dose- dependent intake of farmed Atlantic salmon on lipoprotein particle (P) size and concentration. We hypothesized that LDL-P and HDL-P size and concentration would increase with salmon intake in a dose- dependent manner. (Source: Nutrition Research)
Source: Nutrition Research - June 26, 2016 Category: Nutrition Authors: Susan K. Raatz, LuAnn K. Johnson, Thad A. Rosenberger, Matthew J. Picklo Tags: Original Research Source Type: research
Sesamin ameliorates hepatic steatosis and inflammation in rats on a high-fat diet via LXR α and PPARα
In this study, we hypothesized that sesamin improves lipid homeostasis of Sprague Dawley (SD) rats fed a high-fat diet (HFD) by regulating the expression of genes related to de novo lipogenesis and β-oxidation. We induced NAFLD in rats with HFD and examined the effect of sesamin in vivo. (Source: Nutrition Research)
Source: Nutrition Research - June 26, 2016 Category: Nutrition Authors: Ruijuan Zhang, Yan Yu, Senke Hu, Jinghua Zhang, Haixia Yang, Bei Han, Yue Cheng, Xiaoqin Luo Tags: Original Research Source Type: research
