Panaxatriol derived from ginseng augments resistance exercised-induced protein synthesis via mTORC1 signaling in rat skeletal muscle

Resistance exercise activates muscle protein synthesis via the mammalian target of rapamycin complex 1 (mTORC1) pathway and subsequent muscle hypertrophy. Upstream components of the mTORC1 pathway are widely known to be involved in Akt and ERK1/2 signaling. Previous studies have shown that ginseng stimulated Akt and ERK1/2 signaling. Therefore, we hypothesized that panaxatriol (PT) derived from ginseng triggers mTORC1 signaling and muscle protein synthesis by activating both the Akt and ERK1/2 signaling pathways, and that PT additively stimulates muscle protein synthesis when combined with resistance exercise.

Source: Nutrition Research - September 12, 2016 Category: Nutrition Authors: Yusuke Takamura, Yuhei Makanae, Satoru Ato, Naomi Yoshii, Kohei Kido, Mitsuru Nomura, Akira Uchiyama, Naruhiro Shiozawa, Satoshi Fujita Tags: Original Research Source Type: research