Journal of Cardiovascular Pharmacology and Therapeutics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Preoperative Aspirin Therapy Reduces Early Mortality in Patients Undergoing Cardiac Surgery
(Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 24, 2016 Category: Cardiology Authors: Aboul-Hassan, S. S., Marczak, J., Stankowski, T., Cichon, R. Tags: Clinical Studies Source Type: research

Choice of New Oral Anticoagulant Agents Versus Vitamin K Antagonists in Atrial Fibrillation: FANTASIIA Study
Conclusion: Medical and social variables were associated with prescription of NOAC. Major bleeding, hemorrhagic stroke, university education, and higher glomerular filtration rate were more frequent among patients under NOAC. On the contrary, patients with history of cancer or bradyarrhythmias more frequently received VKA. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 24, 2016 Category: Cardiology Authors: Moreno-Arribas, J., Bertomeu-Gonzalez, V., Anguita-Sanchez, M., Cequier, A., Muniz, J., Castillo, J., Sanchis, J., Roldan, I., Marin, F., Bertomeu-Martinez, V., on behalf of the investigators of the FANTASIIA study Tags: Clinical Studies Source Type: research

Oxygen in the Setting of Acute Myocardial Infarction: Is It Really a Breath of Fresh Air?
Conclusion: High-concentration oxygen may not offer any benefit when compared to titrated oxygen or room air. A large, randomized trial is warranted to further delineate these differences with respect to multiple end points. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 24, 2016 Category: Cardiology Authors: Loomba, R. S., Nijhawan, K., Aggarwal, S., Arora, R. R. Tags: Review Article Source Type: research

Epigenetic Therapy for the Treatment of Hypertension-Induced Cardiac Hypertrophy and Fibrosis
Conclusion: These findings suggest a role for epigenetic modifications in contributing to the profibrotic and hypertrophic changes evident during disease progression. Therapeutic intervention with 5-aza demonstrated favorable effects highlighting the potential use of this epigenetic modifier as a treatment option for cardiac pathologies associated with hypertrophy and fibrosis. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 10, 2015 Category: Cardiology Authors: Watson, C. J., Horgan, S., Neary, R., Glezeva, N., Tea, I., Corrigan, N., McDonald, K., Ledwidge, M., Baugh, J. Tags: Experimental Studies Source Type: research

{beta}3-Adrenoceptor Impairs Mitochondrial Biogenesis and Energy Metabolism During Rapid Atrial Pacing-Induced Atrial Fibrillation
Conclusion: The activation of β3-AR contributes to atrial metabolic remodeling via transcriptional downregulation of PGC-1α/NRF-1/Tfam pathway that are involved in mitochondrial biogenesis, which ultimately perturbs mitochondrial function in rapid pacing-induced AF. The β3-AR is therefore a potential novel therapeutic target for the treatment or prevention of AF. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 10, 2015 Category: Cardiology Authors: Dong, J., Zhao, J., Zhang, M., Liu, G., Wang, X., Liu, Y., Yang, N., Liu, Y., Zhao, G., Sun, J., Tian, J., Cheng, C., Wei, L., Li, Y., Li, W. Tags: Experimental Studies Source Type: research

Erythropoietin Reverses Sepsis-Induced Vasoplegia to Norepinephrine Through Preservation of {alpha}1D-Adrenoceptor mRNA Expression and Inhibition of GRK2-Mediated Desensitization in Mouse Aorta
In conclusion, EPO seems to reverse sepsis-induced vasoplegia to NE through the preservation of α1D adrenoceptor mRNA/protein expression, inhibition of GRK2-mediated desensitization, and attenuation of NO overproduction in the mouse aorta. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 10, 2015 Category: Cardiology Authors: Kandasamy, K., Choudhury, S., Singh, V., Addison, M. P., Darzi, S. A., Kasa, J. K., Thangamalai, R., Dash, J. R., Kumar, T., Sultan, F., Singh, T. U., Parida, S., Mishra, S. K. Tags: Experimental Studies Source Type: research

A Nuclear Magnetic Resonance Spectroscopy as a Method for Evaluation of In Vivo Poly-L-Lactide Biodegradation Kinetics From Stent-Polymer Matrices: An Experimental Study Utilizing Porcine Model of In-Stent Restenosis
Conclusions: The utilization of NMR method for BP absorption kinetics evaluation is a useful tool, which may be widely adopted to test other biodegradable implants. Further, it may substantially improve their safety and efficacy by facilitating programmed polymer and drugs elution. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 10, 2015 Category: Cardiology Authors: Orlik, B., Buszman, P. P., Krauze, A., Gasior, P., Desperak, P., Pajak, J., Kasperczyk, J., Janas, A., Jelonek, M., Handzlik-Orlik, G., Buszman, P. E., Milewski, K. Tags: Experimental Studies Source Type: research

Melatonin Attenuates Aortic Endothelial Permeability and Arteriosclerosis in Streptozotocin-Induced Diabetic Rats: Possible Role of MLCK- and MLCP-Dependent MLC Phosphorylation
This study was designed to evaluate whether melatonin attenuates arteriosclerosis and endothelial permeability by suppressing the myosin light-chain kinase (MLCK)/myosin light-chain phosphorylation (p-MLC) system via the mitogen-activated protein kinase (MAPK) signaling pathway or by suppressing the myosin phosphatase-targeting subunit phosphorylation (p-MYPT)/p-MLC system in diabetes mellitus (DM). Rats were randomly divided into 4 groups, including control, high-fat diet, DM, and DM + melatonin groups. Melatonin was administered (10 mg/kg/d) by gavage for 12 weeks. The DM significantly increased the serum fasting blood g...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 10, 2015 Category: Cardiology Authors: Tang, S.-t., Su, H., Zhang, Q., Tang, H.-q., Wang, C.-j., Zhou, Q., Wei, W., Zhu, H.-q., Wang, Y. Tags: Experimental Studies Source Type: research

The AMPK Agonist PT1 and mTOR Inhibitor 3HOI-BA-01 Protect Cardiomyocytes After Ischemia Through Induction of Autophagy
Myocardial ischemia has become one of the main causes of sudden cardiac death worldwide. Autophagy has been demonstrated to protect cardiomyocytes from ischemia/reperfusion (I/R)-induced damage. A novel small molecule compound 2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoic acid (PT1) has been previously shown to specifically activate 5'-adenosine monophosphate-activated protein kinase (AMPK). Because AMPK activation effectively induces autophagy, we tested the protective efficacy of PT1 on cardiomyocytes after oxygen glucose deprivation/reoxygenation (OGD/R)...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 10, 2015 Category: Cardiology Authors: Huang, L., Dai, K., Chen, M., Zhou, W., Wang, X., Chen, J., Zhou, W. Tags: Experimental Studies Source Type: research

Intestinal Barrier Dysfunction: A Novel Therapeutic Target for Inflammatory Response in Acute Stanford Type A Aortic Dissection
Conclusions: Intestinal barrier dysfunction, reflected by an increased level of serum DAO, may play an important role in the development of systemic inflammatory responses in patients with ATAAD. Therefore, strategies of preserving a normal intestinal barrier function may open new horizons in the treatment of inflammation-related adverse events in the setting of ATAAD. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 10, 2015 Category: Cardiology Authors: Gu, J., Hu, J., Qian, H., Shi, Y., Zhang, E., Guo, Y., Xiao, Z., Fang, Z., Zhong, M., Zhang, H., Meng, W. Tags: Clinical Studies Source Type: research

Remote Ischemic Conditioning for Preventing Contrast-Induced Acute Kidney Injury in Patients Undergoing Percutaneous Coronary Interventions/Coronary Angiography: A Meta-Analysis of Randomized Controlled Trials
Conclusion: The RIC reduced the incidence of CI-AKI in those receiving PCI/CAG. And RIC of the upper arm significantly reduced the risk of CI-AKI but not RIC of the lower limb in patients undergoing PCI/CAG. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 10, 2015 Category: Cardiology Authors: Bei, W.-j., Duan, C.-y., Chen, J.-y., Wang, K., Liu, Y.-h., Liu, Y., Tan, N. Tags: Clinical Studies Source Type: research

Influence of Different {beta}-Blockers on Platelet Aggregation in Patients With Coronary Artery Disease on Dual Antiplatelet Therapy
Conclusion: Patients with CAD on dual antiplatelet therapy who used nebivolol had significantly lower levels of residual ADP-induced platelet aggregation compared to baseline than patients who used bisoprolol. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 10, 2015 Category: Cardiology Authors: Ignjatovic, V., Pavlovic, S., Miloradovic, V., Andjelkovic, N., Davidovic, G., Djurdjevic, P., Stolic, R., Iric-Cupic, V., Simic, I., Ignjatovic, V. D., Petrovic, N., Smiljanic, Z., Zdravkovic, V., Simovic, S., Jovanovic, D., Nesic, J. Tags: Clinical Studies Source Type: research

Roles of Testosterone Replacement in Cardiac Ischemia-Reperfusion Injury
Testosterone is an anabolic steroid hormone, which is the major circulating androgen hormone in males. Testosterone levels decreasing below the normal physiological levels lead to a status known as androgen deficiency. Androgen deficiency has been shown to be a major risk factor in the development of several disorders, including obesity, metabolic syndrome, and ischemic heart disease. In the past decades, although several studies from animal models as well as clinical studies demonstrated that testosterone exerted cardioprotection, particularly during ischemia–reperfusion (I/R) injury, other preclinical and clinical ...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 10, 2015 Category: Cardiology Authors: Pongkan, W., Chattipakorn, S. C., Chattipakorn, N. Tags: Review Article Source Type: research

Cardiovascular Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics for the Clinical Practitioner
Current clinical cardiovascular practice requires a clinician to have a strong foundation in multiple aspects of pharmacology. Modern cardiovascular regimens are complex, and optimal management, application of evolving guidelines, and adoption of new therapies build off a more basic understanding of pharmacokinetics and pharmacodynamics. In addition, it is likely time to add a third pillar into this discussion, the expanding field of pharmacogenomics referring to the genetic influences on drug response. This field has increasing applications in medicine and clearly holds significant promise for cardiovascular disease manag...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 10, 2015 Category: Cardiology Authors: Sleder, A. T., Kalus, J., Lanfear, D. E. Tags: Cardiovascular Pharmacology Core Reviews Source Type: research

Direct Vasodilators and Sympatholytic Agents
Direct vasodilators and sympatholytic agents were some of the first antihypertensive medications discovered and utilized in the past century. However, side effect profiles and the advent of newer antihypertensive drug classes have reduced the use of these agents in recent decades. Outcome data and large randomized trials supporting the efficacy of these medications are limited; however, in general the blood pressure-lowering effect of these agents has repeatedly been shown to be comparable to other more contemporary drug classes. Nevertheless, a landmark hypertension trial found a negative outcome with a doxazosin-based re...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 10, 2015 Category: Cardiology Authors: McComb, M. N., Chao, J. Y., Ng, T. M. H. Tags: Cardiovascular Pharmacology Core Reviews Source Type: research