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Electrophysiological and Antiarrhythmic Properties of Potassium Canrenoate During Myocardial Ischemia-Reperfusion
Conclusion: Our experimental study highlights new evidence for an antiarrhythmic impact of PC during myocardial ischemia–reperfusion via multiple channels modulation. These results are in line with recent clinical trials suggesting that an early MR blockade in STEMI may be preventive of VAs. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 15, 2015 Category: Cardiology Authors: Alexandre, J., Beygui, F., Puddu, P.-E., Manrique, A., Rouet, R., Milliez, P. Tags: Experimental Studies Source Type: research

Effect of Chronic Heart Rate Reduction by I f Current Inhibitor Ivabradine on Left Ventricular Remodeling and Systolic Performance in Middle-Aged Rats With Postmyocardial Infarction Heart Failure
Conclusion: Our data reveal that chronic IVA-induced HRR does not provide sustainable benefits for LV systolic performance in middle-aged rats with post-MI HF. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 15, 2015 Category: Cardiology Authors: Dedkov, E. I., Bogatyryov, Y., McCooey, D. S., Christensen, L. P., Weiss, R. M., Tomanek, R. J. Tags: Experimental Studies Source Type: research

Effect of Probiotic Lactobacillus salivarius UBL S22 and Prebiotic Fructo-oligosaccharide on Serum Lipids, Inflammatory Markers, Insulin Sensitivity, and Gut Bacteria in Healthy Young Volunteers: A Randomized Controlled Single-Blind Pilot Study
This study investigated the effect of 6-week supplementation of a probiotic strain Lactobacillus salivarius UBL S22 with or without prebiotic fructo-oligosaccharide (FOS) on serum lipid profiles, immune responses, insulin sensitivity, and gut lactobacilli in 45 healthy young individuals. The patients were divided into 3 groups (15/group), that is, placebo, probiotic, and synbiotic. After 6 weeks, a significant reduction (P < .05) in total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides and increase in high-density lipoprotein cholesterol was observed in the probiotic as well as in the synbiotic...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 15, 2015 Category: Cardiology Authors: Rajkumar, H., Kumar, M., Das, N., Kumar, S. N., Challa, H. R., Nagpal, R. Tags: Clinical Studies Source Type: research

Topical Nitroglycerin Ointment for Treatment of Acute Hypertension in Hospitalized Inpatients
Conclusion: Study results suggest possible efficacy of nitroglycerin ointment for the treatment of acute hypertension in noncardiac hospitalized patients. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 15, 2015 Category: Cardiology Authors: Brower, K. A., Garcia, N. A. T., Smith, H. L., Wall, G. C. Tags: Clinical Studies Source Type: research

The Effect of Rosuvastatin on Low-Density Lipoprotein Subfractions in Patients With Impaired Fasting Glucose
Conclusion: Targeting dyslipidemia with rosuvastatin was associated with more favorable changes in the LDL subfraction profile in patients with IFG compared to normoglycemic ones. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 15, 2015 Category: Cardiology Authors: Rizos, C. V., Kostapanos, M. S., Rizos, E. C., Tselepis, A. D., Elisaf, M. S. Tags: Clinical Studies Source Type: research

How Do We Prevent the Vulnerable Atherosclerotic Plaque From Rupturing? Insights From In Vivo Assessments of Plaque, Vascular Remodeling, and Local Endothelial Shear Stress
Coronary atherosclerosis progresses both as slow, gradual enlargement of focal plaque and also as a more dynamic process with periodic abrupt changes in plaque geometry, size, and morphology. Systemic vasculoprotective therapies such as statins, angiotensin-converting enzyme inhibitors, and antiplatelet agents are the cornerstone of prevention of plaque rupture and new adverse clinical outcomes, but such systemic therapies are insufficient to prevent the majority of new cardiac events. Invasive imaging methods have been able to identify both the anatomic features of high-risk plaque and the ongoing pathobiological stimuli ...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 15, 2015 Category: Cardiology Authors: Andreou, I., Antoniadis, A. P., Shishido, K., Papafaklis, M. I., Koskinas, K. C., Chatzizisis, Y. S., Coskun, A. U., Edelman, E. R., Feldman, C. L., Stone, P. H. Tags: Review Article Source Type: research

Pharmacotherapy Update on the Use of Vasopressors and Inotropes in the Intensive Care Unit
This paper summarizes the pharmacologic properties of vasoactive medications used in the treatment of shock, including the inotropes and vasopressors. The clinical application of these therapies is discussed and recent studies describing their use and associated outcomes are also reported. Comprehension of hemodynamic principles and adrenergic and non-adrenergic receptor mechanisms are salient to the appropriate therapeutic utility of vasoactive medications for shock. Vasoactive medications can be classified based on their direct effects on vascular tone (vasoconstriction or vasodilation) and on the heart (presence or abse...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 15, 2015 Category: Cardiology Authors: Jentzer, J. C., Coons, J. C., Link, C. B., Schmidhofer, M. Tags: Cardiovascular Pharmacology Core Review Source Type: research

Chronic Treatment With Qiliqiangxin Ameliorates Aortic Endothelial Cell Dysfunction in Diabetic Rats
Qiliqiangxin (QL), a traditional Chinese medicine, has been shown to be beneficial for chronic heart failure. However, whether QL can also improve endothelial cell function in diabetic rats remains unknown. Here, we investigated the effect of QL treatment on endothelial dysfunction by comparing the effect of QL to that of benazepril (Ben) in diabetic Sprague-Dawley rats for 8 weeks. Cardiac function was evaluated by echocardiography and catheterization. Assays for acetylcholine-induced, endothelium-dependent relaxation (EDR), sodium nitroprusside-induced endothelium-independent relaxation, serum nitric oxide (NO), and nitr...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 9, 2015 Category: Cardiology Authors: Chen, F., Wu, J.-L., Fu, G.-S., Mou, Y., Hu, S.-J. Tags: Experimental Studies Source Type: research

Examination of the Effects of Thiamine and Thiamine Pyrophosphate on Doxorubicin-Induced Experimental Cardiotoxicity
Conclusion and Implications: The cardiotoxic effect of doxorubicin originated from the inhibition of TPK enzyme resulting in insufficient production of thiamine pyrophosphate. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 9, 2015 Category: Cardiology Authors: Polat, B., Suleyman, H., Sener, E., Akcay, F. Tags: Experimental Studies Source Type: research

Heart Remodeling and Ischemia-Reperfusion Arrhythmias Linked to Myocardial Vitamin D Receptors Deficiency in Obstructive Nephropathy Are Reversed by Paricalcitol
Cardiovascular disease is often associated with chronic kidney disease and vice versa; myocardial vitamin D receptors (VDRs) are among the probable links between the 2 disorders. The vitamin D receptor activator paricalcitol protects against some renal and cardiovascular complications. However, the structural and electrophysiological effects of myocardial vitamin D receptor modification and its impact on the response to ischemia–reperfusion are currently unknown. This work attempted to determine whether obstructive nephropathy induced myocardial changes (in rats) linked to vitamin D receptor deficiency and to ventric...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 9, 2015 Category: Cardiology Authors: Diez, E. R., Altamirano, L. B., Garcia, I. M., Mazzei, L., Prado, N. J., Fornes, M. W., Carrion, F. D. C., Zumino, A. Z. P., Ferder, L., Manucha, W. Tags: Experimental Studies Source Type: research

N-Acetylcysteine Ameliorates Experimental Autoimmune Myocarditis in Rats via Nitric Oxide
Conclusion: Treatment with NAC ameliorated myocardial injury via NO system in a rat model of myocarditis. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 9, 2015 Category: Cardiology Authors: Shimada, K., Uzui, H., Ueda, T., Lee, J.-D., Kishimoto, C. Tags: Experimental Studies Source Type: research

Rapid Induction of Hypothermia by the ThermoSuit System Profoundly Reduces Infarct Size and Anatomic Zone of No Reflow Following Ischemia-Reperfusion in Rabbit and Rat Hearts
Conclusion: The ThermoSuit device induced rapid hypothermia and limited infarct size and no reflow to the greatest extent ever observed in this laboratory with a single intervention. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 9, 2015 Category: Cardiology Authors: Herring, M. J., Dai, W., Hale, S. L., Kloner, R. A. Tags: Experimental Studies Source Type: research

Statins for the Prevention of Contrast-Induced Nephropathy After Coronary Angiography/Percutaneous Interventions: A Meta-analysis of Randomized Controlled Trials
Conclusion: This updated meta-analysis demonstrated that preprocedural statin treatment could reduce the risk of CIN and the need for RRT in patients undergoing coronary angiography/percutaneous interventions. Moreover, statin therapy would be helpful in reducing the incidence of CIN in high-risk patients with preexisting renal dysfunction or diabetes mellitus. Additionally, rosuvastatin and atorvastatin had similar efficacies in preventing CIN development. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 9, 2015 Category: Cardiology Authors: Liu, Y.-h., Liu, Y., Duan, C.-y., Tan, N., Chen, J.-y., Zhou, Y.-l., Li, L.-w., He, P.-c. Tags: Clinical Studies Source Type: research

Hydroxychloroquine's Efficacy as an Antiplatelet Agent Study in Healthy Volunteers: A Proof of Concept Study
Conclusion: This study suggests that HCQ has antiplatelet properties possibly through the AA pathway (downstream to thromboxane A2 production). With possible additional beneficial effects over the traditional CVD risk factors, larger studies in the future might explore HCQ’s potential as an antiplatelet agent. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 9, 2015 Category: Cardiology Authors: Achuthan, S., Ahluwalia, J., Shafiq, N., Bhalla, A., Pareek, A., Chandurkar, N., Malhotra, S. Tags: Clinical Studies Source Type: research

The Combination of Elevated Triglycerides and Abnormal Fasting Glucose Increases Risk of Cerebral Infarction in Patients With Mild to Moderate Hypercholesterolemia: A Post Hoc Analysis of the MEGA Study
Conclusions: Our findings contribute to the formulation of the hypothesis that patients with hypercholesterolemia having AFG plus high TGs have an increased risk of cerebral infarction. These are compatible with the result from the main study that patients with hypercholesterolemia randomized to diet plus pravastatin had a reduced risk of cerebral infarction. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 9, 2015 Category: Cardiology Authors: Nakagami, T., Nishimura, R., Sone, H., Tajima, N. Tags: Clinical Studies Source Type: research