Journal of Cardiovascular Pharmacology and Therapeutics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

MiR-155 Knockout in Fibroblasts Improves Cardiac Remodeling by Targeting Tumor Protein p53-Inducible Nuclear Protein 1
In this study, we investigate the role of miR-155 in cardiac remodeling induced by AMI. We demonstrate that miR-155 expressed in cardiac fibroblasts is a potent contributor to cardiac remodeling. We reveal that in vivo, miR-155 knockout improves left ventricular function, reduces infarct size, and attenuates collagen deposition, whereas overexpression of miR-155 produces the opposite effects. MiR-155 knockout also inhibits cardiac fibroblast proliferation and differentiation into myofibroblasts. In addition, downregulation of tumor protein p53-inducible nuclear protein 1 (TP53INP1) by small interfering RNA reverses the eff...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - May 31, 2016 Category: Cardiology Authors: He, W., Huang, H., Xie, Q., Wang, Z., Fan, Y., Kong, B., Huang, D., Xiao, Y. Tags: Experimental Studies Source Type: research

Inhibition of Atherosclerosis Progression, Intimal Hyperplasia, and Oxidative Stress by Simvastatin and Ivabradine May Reduce Thoracic Aortas Stiffness in Hypercholesterolemic Rabbits
Conclusion: Simvastatin and ivabradine significantly inhibited intimal hyperplasia and oxidative stress contributing to aortic stiffness reduction in hyperlipidemic rabbits. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - May 31, 2016 Category: Cardiology Authors: Koniari, I., Mavrilas, D., Apostolakis, E., Papadimitriou, E., Papadaki, H., Papalois, A., Poimenidi, E., Xanthopoulou, I., Hahalis, G., Alexopoulos, D. Tags: Experimental Studies Source Type: research

Effect of Elevated Reperfusion Pressure on "No Reflow" Area and Infarct Size in a Porcine Model of Ischemia-Reperfusion
Conclusions: Modestly elevated blood pressure during reperfusion is associated with an increase in no reflow area and in infarct size in a clinically relevant porcine model of ischemia–reperfusion. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - May 31, 2016 Category: Cardiology Authors: Pantsios, C., Kapelios, C., Vakrou, S., Diakos, N., Pozios, I., Kontogiannis, C., Nanas, J., Malliaras, K. Tags: Experimental Studies Source Type: research

Effects of RAAS Blockers on Atrial Fibrillation Prophylaxis: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials
Conclusion: This study suggests that RAAS blockade effectively suppresses AF in systolic heart failure, and hypertensives derive greater benefit against new-onset and recurrent AF compared to β blockers, calcium channel blockers, and diuretics. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - May 31, 2016 Category: Cardiology Authors: Chaugai, S., Meng, W. Y., Ali Sepehry, A. Tags: Clinical Studies Source Type: research

Clinical Effect of Cardiac Shock Wave Therapy on Myocardial Ischemia in Patients With Ischemic Heart Failure
Conclusions: Cardiac shock wave therapy can improve myocardial ischemia and represents as a treatment option for patients with ischemic HF through promoting neovascularization and inhibiting cell apoptosis. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - May 31, 2016 Category: Cardiology Authors: Wang, W., Liu, H., Song, M., Fang, W., Yuan, F. Tags: Clinical Studies Source Type: research

Assessment of Anti-Tissue Type Plasminogen Activator Antibodies in Patients With Prosthetic Heart Valve Thrombosis: The ATA Trial
Conclusion: The ATA levels tended to be higher in patients with PVT at the time of initial diagnosis compared to controls without PVT. In addition, such patients with PVT and high ATA levels may be at high risk for failed thrombolysis or rethrombosis. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - May 31, 2016 Category: Cardiology Authors: Özkan, M., Kalcık, M., Gürsoy, M. O., Öcal, L., Griffini, S., Karakoyun, S., Yesin, M., Gündüz, S., Astarcıoglu, M. A., Bayam, E., Cersit, S., Aykan, A. C., Cugno, M. Tags: Clinical Studies Source Type: research

Hypothesis: Metalloproteinase Inhibitors Decrease Risks of Cardiovascular Disease
The hypothesis that matrix metalloproteinase (MMP) inhibitors reduce risks of cardiovascular disease in humans is plausible, unproven, and difficult to test, due, in part, to differences in specificity and route of administration. Endogenous tissue inhibitors of metalloproteinases (TIMPs) are tight-binding, protein inhibitors that function in vivo and can be engineered to enhance specificity for desired targets. Nonetheless, TIMPs have been difficult to test, in part, because their secondary functions, including cell growth promotion and angiogenesis, raise concerns about side effects and they cannot be delivered orally. I...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - May 31, 2016 Category: Cardiology Authors: Lizotte-Waniewski, M., Brew, K., Hennekens, C. H. Tags: Editorial Source Type: research

Approaches to Improving Cardiac Structure and Function During and After an Acute Myocardial Infarction: Acute and Chronic Phases
While progress has been made in improving survival following myocardial infarction, this injury remains a major source of mortality and morbidity despite modern reperfusion therapy. While one approach has been to develop therapies to reduce lethal myocardial cell reperfusion injury, this concept has not translated to the clinics, and several recent negative clinical trials raise the question of whether reperfusion injury is important in humans undergoing reperfusion for acute ST segment elevation myocardial infarction. Therapy aimed at reducing myocardial cell death while the myocytes are still ischemic is more likely to f...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - May 31, 2016 Category: Cardiology Authors: Kloner, R. A., Dai, W., Hale, S. L., Shi, J. Tags: Review Articles Source Type: research

Relaxin the Heart: A Novel Therapeutic Modality
The peptide hormone relaxin has traditionally been linked to the maternal adaptation of the cardiovascular system during the first trimester of pregnancy. By promoting nitric oxide formation through different molecular signaling events, relaxin has been proposed as a pleiotropic and cardioprotective hormone in the setting of many cardiovascular diseases. In fact, preclinical studies were able to demonstrate that relaxin promotes vasodilatation and angiogenesis, ameliorates ischemia/reperfusion injury, and regulates extracellular matrix turnover and remodeling. In the RELAX-AHF phase 3 clinical trial, serelaxin (recombinant...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - May 31, 2016 Category: Cardiology Authors: Raleigh, J. M. V., Toldo, S., Das, A., Abbate, A., Salloum, F. N. Tags: Review Articles Source Type: research

The Potential Role of Catheter-Based Renal Sympathetic Denervation in Chronic and End-Stage Kidney Disease
Sympathetic activation is a hallmark of chronic and end-stage renal disease and adversely affects cardiovascular prognosis. Hypertension is present in the vast majority of these patients and plays a key role in the progressive deterioration of renal function and the high rate of cardiovascular events in this patient cohort. Augmentation of renin release, tubular sodium reabsorption, and renal vascular resistance are direct consequences of efferent renal sympathetic nerve stimulation and the major components of neural regulation of renal function. Renal afferent nerve activity directly influences sympathetic outflow to the ...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - May 31, 2016 Category: Cardiology Authors: Sata, Y., Schlaich, M. P. Tags: Review Articles Source Type: research

Ivabradine: Heart Failure and Beyond
Heart failure affects over 5 million people in the United States and carries a high rate of mortality. Ivabradine, a new agent has been added to the current medical options for managing heart failure. It is a selective funny current (If) inhibitor in sinoatrial node and slows its firing rate, prolonging diastolic depolarization without a negative inotropic effect. Ivabradine was only recently approved by Food and Drug administration after the results of Systolic Heart Failure Treatment with the If Inhibitor Ivabradine (SHIFT) trial, for a reduction in rehospitalizations from chronic heart failure. This trial assessed patie...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - May 31, 2016 Category: Cardiology Authors: Chaudhary, R., Garg, J., Krishnamoorthy, P., Shah, N., Lanier, G., Martinez, M. W., Freudenberger, R. Tags: Cardiovascular Pharmacology Core Review Source Type: research

Comparative Effects of Diet-Induced Lipid Lowering Versus Lipid Lowering Along With Apo A-I Milano Gene Therapy on Regression of Atherosclerosis
In this study, we compared the effect of dietary lipid lowering versus lipid lowering plus Apo A-IM gene transfer using recombinant adeno-associated virus (rAAV) 8 as vectors on atherosclerosis regression in Apo A-I/Apo E null mice. All mice were fed a high-cholesterol diet from age of 6 weeks until week 20, and at 20 weeks, 10 mice were euthanized to determine the extent of atherosclerosis. After 20 weeks, an additional 20 mice were placed on either a low-cholesterol diet plus empty rAAV (n = 10) to serve as controls or low-cholesterol diet plus 1 single intravenous injection of 1.2 x 1012 vector genomes of adeno-associat...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 9, 2016 Category: Cardiology Authors: Wang, L., Tian, F., Arias, A., Yang, M., Sharifi, B. G., Shah, P. K. Tags: Experimental Studies Source Type: research

The Cardioprotective Effects of Late-Phase Remote Preconditioning of Trauma Depends on Neurogenic Pathways and the Activation of PKC and NF-{kappa}B (But Not iNOS) in Mice
Conclusion: Late RPCT significantly decreased myocardial infarct size via neurogenic transmission and various other signaling pathways. This protective mechanism differentiates late and early RPCT. This study describes a new cardiac I/R injury prevention method and refines the concept of RPCT. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 9, 2016 Category: Cardiology Authors: Song, Y., Ye, Y. J., Li, P. W., Zhao, Y. L., Miao, Q., Hou, D. Y., Ren, X. P. Tags: Experimental Studies Source Type: research

Discovery of Potential Therapeutic miRNA Targets in Cardiac Ischemia-Reperfusion Injury
Conclusion: Mimicking miRNA changes caused by cardioprotective agents, combined with functional screening, enables investigators to efficiently identify novel miRNAs with therapeutic potential in cardiac I/R. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 9, 2016 Category: Cardiology Authors: Zhou, Y., Chen, Q., Lew, K. S., Richards, A. M., Wang, P. Tags: Experimental Studies Source Type: research

Characterization of the Langendorff Perfused Isolated Mouse Heart Model of Global Ischemia-Reperfusion Injury: Impact of Ischemia and Reperfusion Length on Infarct Size and LDH Release
Conclusion: Myocardial IS measured by triphenyltetrazolium staining depends on both the duration of ischemia and the length of the reperfusion period. The LDH assessment may not be the most reliable tool to assess IS and/or to examine cardioprotective effectiveness at various times of ischemia. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 9, 2016 Category: Cardiology Authors: Rossello, X., Hall, A. R., Bell, R. M., Yellon, D. M. Tags: Experimental Studies Source Type: research