Characterization of the Langendorff Perfused Isolated Mouse Heart Model of Global Ischemia-Reperfusion Injury: Impact of Ischemia and Reperfusion Length on Infarct Size and LDH Release

Conclusion:
Myocardial IS measured by triphenyltetrazolium staining depends on both the duration of ischemia and the length of the reperfusion period. The LDH assessment may not be the most reliable tool to assess IS and/or to examine cardioprotective effectiveness at various times of ischemia.

Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 9, 2016 Category: Cardiology Authors: Rossello, X., Hall, A. R., Bell, R. M., Yellon, D. M. Tags: Experimental Studies Source Type: research