The Cardioprotective Effects of Late-Phase Remote Preconditioning of Trauma Depends on Neurogenic Pathways and the Activation of PKC and NF-{kappa}B (But Not iNOS) in Mice

Conclusion:
Late RPCT significantly decreased myocardial infarct size via neurogenic transmission and various other signaling pathways. This protective mechanism differentiates late and early RPCT. This study describes a new cardiac I/R injury prevention method and refines the concept of RPCT.

Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 9, 2016 Category: Cardiology Authors: Song, Y., Ye, Y. J., Li, P. W., Zhao, Y. L., Miao, Q., Hou, D. Y., Ren, X. P. Tags: Experimental Studies Source Type: research