Journal of Cardiovascular Pharmacology and Therapeutics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Does Oral Beta-Blocker Therapy Improve Long-Term Survival in ST-Segment Elevation Myocardial Infarction With Preserved Systolic Function? A Meta-Analysis
Conclusion: This meta-analysis demonstrates that oral beta-blocker therapy is associated with decreased all-cause mortality in patients with STEMI who are treated with primary PCI and who have preserved LVEF. This supports the current American College of Cardiology Foundation/American Heart Association 2013 Guideline for the Management of STEMI. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 9, 2016 Category: Cardiology Authors: Misumida, N., Harjai, K., Kernis, S., Kanei, Y. Tags: Clinical Studies Source Type: research

Impact of Digoxin on Mortality in Patients With Atrial Fibrillation Stratified by Heart Failure: Findings From Gulf Survey of Atrial Fibrillation Events in the Middle East
Conclusions: In patients with AF and HF, digoxin did not offer any survival advantages. However, in those without HF, digoxin therapy was, in fact, associated with significantly higher long-term mortality. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 9, 2016 Category: Cardiology Authors: Al-Zakwani, I., Panduranga, P., Zubaid, M., Sulaiman, K., Rashed, W. A., Alsheikh-Ali, A. A., AlMahmeed, W., Shehab, A., Al Qudaimi, A., Asaad, N., Amin, H. Tags: Clinical Studies Source Type: research

Prospects for Creation of Cardioprotective Drugs Based on Cannabinoid Receptor Agonists
Cannabinoids can mimic the infarct-reducing effect of early ischemic preconditioning, delayed ischemic preconditioning, and ischemic postconditioning against myocardial ischemia/reperfusion. They do this primarily through both CB1 and CB2 receptors. Cannabinoids are also involved in remote preconditioning of the heart. The cannabinoid receptor ligands also exhibit an antiapoptotic effect during ischemia/reperfusion of the heart. The acute cardioprotective effect of cannabinoids is mediated by activation of protein kinase C, extracellular signal-regulated kinase, and p38 kinase. The delayed cardioprotective effect of cannab...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 9, 2016 Category: Cardiology Authors: Maslov, L. N., Khaliulin, I., Zhang, Y., Krylatov, A. V., Naryzhnaya, N. V., Mechoulam, R., De Petrocellis, L., Downey, J. M. Tags: Reviews Source Type: research

A Central Role for Monocyte-Platelet Interactions in Heart Failure
Heart failure (HF) is an increasingly prevalent and costly multifactorial syndrome with high morbidity and mortality rates. The exact pathophysiological mechanisms leading to the development of HF are not completely understood. Several emerging paradigms implicate cardiometabolic risk factors, inflammation, endothelial dysfunction, myocardial fibrosis, and myocyte dysfunction as key factors in the gradual progression from a healthy state to HF. Inflammation is now a recognized factor in disease progression in HF and a therapeutic target. Furthermore, the monocyte–platelet interaction has been highlighted as an import...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 9, 2016 Category: Cardiology Authors: Glezeva, N., Gilmer, J. F., Watson, C. J., Ledwidge, M. Tags: Reviews Source Type: research

Antihypertensive Drugs and Male Sexual Dysfunction: A Review of Adult Hypertension Guideline Recommendations
Conclusion: Future guideline revisions, including both full and summary reports, should provide a balanced perspective on antihypertensive-related SD issues to improve the impact of hypertension treatment guidelines on patient care and quality of life. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 9, 2016 Category: Cardiology Authors: Al Khaja, K. A. J., Sequeira, R. P., Alkhaja, A. K., Damanhori, A. H. H. Tags: Reviews Source Type: research

Extended-Duration Thromboprophylaxis Among Acute Medically Ill Patients: An Unmet Need
Acute medical illnesses are associated with a prolonged elevation in inflammatory markers that predisposes patients to thrombosis beyond the duration of their hospital stay. In parallel, both observational and randomized data have demonstrated a rate of postdischarge venous thromboembolic events that often exceeds that observed in the hospital setting. Despite this significant residual risk of venous thromboembolic events following discharge among acute medically ill patients, no therapeutic strategies have been recommended to address this unmet need. Available randomized trials have demonstrated the efficacy of extending ...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 9, 2016 Category: Cardiology Authors: Korjian, S., Daaboul, Y., Halaby, R., Goldhaber, S. Z., Cohen, A. T., Singh, K., Susheela, A. T., Harrington, R. A., Hull, R. D., Hernandez, A. F., Gibson, C. M. Tags: Cardiovascular Pharmacology Core Review Source Type: research

Statin Use and Risk of Cataract Response to Letter
(Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 24, 2016 Category: Cardiology Authors: Kostis, J. B., Dobrzynski, J. M. Tags: Letters to the Editor Source Type: research

Response to Letter on Statin Use and Risk of Cataracts: Firm Conclusions Are Still Off
(Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 24, 2016 Category: Cardiology Authors: Hippisley-Cox, J. Tags: Letters to the Editor Source Type: research

Remote Ischemic Conditioning: Its Benefits and Limitations
This editorial describes benefits and limitations of remote ischemic conditioning. Remote ischemic conditioning was shown to reduce myocardial intact size in at least 4 sizeable clinical trials of acute myocardial infarction. It was not effective in recent studies of cardiac surgery. Reasons for these differences are discussed. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 24, 2016 Category: Cardiology Authors: Kloner, R. A. Tags: Editorial Source Type: research

Coronary Microembolization Induces Cardiomyocyte Apoptosis in Swine by Activating the LOX-1-Dependent Mitochondrial Pathway and Caspase-8-Dependent Pathway
Conclusion: Coronary microembolization induces cardiomyocyte apoptosis via the LOX-1-dependent mitochondrial pathway and caspase 8-dependent pathway. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 24, 2016 Category: Cardiology Authors: Liu, T., Zhou, Y., Wang, J.-Y., Su, Q., Tang, Z.-L., Liu, Y.-C., Li, L. Tags: Experimental Studies Source Type: research

Skeletal Muscle Vascular Control During Exercise: Impact of Nitrite Infusion During Nitric Oxide Synthase Inhibition in Healthy Rats
The nitric oxide synthase (NOS)-independent pathway of nitric oxide (NO) production in which nitrite (NO2–) is reduced to NO may have therapeutic applications for those with cardiovascular diseases in which the NOS pathway is downregulated. We tested the hypothesis that NO2– infusion would reduce mean arterial pressure (MAP) and increase skeletal muscle blood flow (BF) and vascular conductance (VC) during exercise in the face of NOS blockade via L-NAME. Following infusion of L-NAME (10 mg kg–1, L-NAME), male Sprague-Dawley rats (3-6 months, n = 8) exercised without NG-nitro-L arginine methyl ester (L-NAME...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 24, 2016 Category: Cardiology Authors: Ferguson, S. K., Glean, A. A., Holdsworth, C. T., Wright, J. L., Fees, A. J., Colburn, T. D., Stabler, T., Allen, J. D., Jones, A. M., Musch, T. I., Poole, D. C. Tags: Experimental Studies Source Type: research

Gingerol Inhibits Serum-Induced Vascular Smooth Muscle Cell Proliferation and Injury-Induced Neointimal Hyperplasia by Suppressing p38 MAPK Activation
Conclusion: Gingerol prevented FBS-induced VSMC proliferation and balloon injury-induced neointima formation by regulating p38 MAPK. Vasodilator effect of gingerol observed in the thoracic aorta was partially endothelium dependent. Gingerol is thus proposed as an attractive agent for modulating VSMC proliferation, vascular reactivity, and progression of vascular proliferative diseases. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 24, 2016 Category: Cardiology Authors: Jain, M., Singh, A., Singh, V., Maurya, P., Barthwal, M. K. Tags: Experimental Studies Source Type: research

The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury
Conclusion: The RSK plays a crucial role in I/R-induced activation of NHE1 and cardiac injury. The RSK inhibition may provide an alternative target for patients with MI. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 24, 2016 Category: Cardiology Authors: Shi, X., ONeill, M. M., MacDonnell, S., Brookes, P. S., Yan, C., Berk, B. C. Tags: Experimental Studies Source Type: research

Statin Antiarrhythmic Effect on Atrial Fibrillation in Statin-Naive Patients Undergoing Cardiac Surgery: A Meta-Analysis of Randomized Controlled Trials
Conclusion: Perioperative statin therapy in statin-naive patients with sinus rhythm undergoing cardiac surgeries was associated with decreases in the development of postoperative AF, the hospital LOS, and the CRP level. However, there were insufficient data to provide evidences regarding statin impacts in patients undergoing isolated valvular surgery. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 24, 2016 Category: Cardiology Authors: Rezaei, Y., Gholami-Fesharaki, M., Dehghani, M. R., Arya, A., Haghjoo, M., Arjmand, N. Tags: Clinical Studies Source Type: research

Impact of Rosuvastatin in Contrast-Induced Acute Kidney Injury in the Elderly: Post Hoc Analysis of the PRATO-ACS Trial
Conclusion: Patients ≥75 years with ACS had a higher risk of developing CI-AKI. Early high-dose rosuvastatin is efficacious in reducing kidney injury in all patients, especially those with the highest baseline hs-CRP values. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 24, 2016 Category: Cardiology Authors: Tropeano, F., Leoncini, M., Toso, A., Maioli, M., Dabizzi, L., Biagini, D., Villani, S., Bellandi, F. Tags: Clinical Studies Source Type: research