Journal of Cardiovascular Pharmacology and Therapeutics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Effects of Combination Therapy With Olmesartan and Azelnidipine on Serum Osteoprotegerin in Patients With Hypertension
Conclusion: Azelnidipine, but not indapamide, combined with olmesartan, improved arterial stiffness and were associated with significant decrease in OPG, MMP-2, and hs-CRP concentrations. These results suggest that the beneficial effects of the combination treatments of olmesartan/azelnidipine on arterial stiffness are mediated by alteration in bone-remodeling and inflammatory markers. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 16, 2014 Category: Cardiology Authors: Uzui, H., Morishita, T., Nakano, A., Amaya, N., Fukuoka, Y., Ishida, K., Arakawa, K., Lee, J.-D., Tada, H. Tags: Clinical Studies Source Type: research

Efficacy and Safety of Alternate Day Therapy With Atorvastatin and Fenofibrate Combination in Mixed Dyslipidemia: A Randomized Controlled Trial
Conclusion: Alternate day therapy with atorvastatin–fenofibrate combination is an effective and safe alternative to daily therapy in mixed dyslipidemia. Apart from significant cost savings, reasonable reduction in the incidence of adverse events is seen with alternate day regimen. However, larger studies are needed to more reliably confirm our interesting but preliminary results. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 16, 2014 Category: Cardiology Authors: Harivenkatesh, N., David, D. C., Haribalaji, N., Sudhakar, M. K. Tags: Clinical Studies Source Type: research

High-Dose Atorvastatin Reloading Before Percutaneous Coronary Intervention Increased Circulating Endothelial Progenitor Cells and Reduced Inflammatory Cytokine Expression During the Perioperative Period
Conclusion: Our results suggested that high-dose atorvastatin application before PCI triggered early EPC circulation. Furthermore, postoperative inflammatory cytokine sICAM-1 as well as hCRP serum levels were reduced, while postinterventional myocardial injury marker TnI elevations were inversely correlated with statin reloadings. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 16, 2014 Category: Cardiology Authors: Ye, H., He, F., Fei, X., Lou, Y., Wang, S., Yang, R., Hu, Y., Chen, X. Tags: Clinical Studies Source Type: research

Evacetrapib at a Supratherapeutic Steady State Concentration Does Not Prolong QT in a Thorough QT/QTc Study in Healthy Participants
Conclusions: Evacetrapib is not associated with QT interval prolongation, even at supratherapeutic doses. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 16, 2014 Category: Cardiology Authors: Suico, J. G., Friedrich, S., Krueger, K. A., Zhang, W. Tags: Clinical Studies Source Type: research

Novel Approaches and Opportunities for Cardioprotective Signaling Through 3',5'-Cyclic Guanosine Monophosphate Manipulation
Limiting the injurious effects of myocardial ischemia-reperfusion is a desirable therapeutic target, which has been investigated extensively over the last three decades. Here we provide an up to date review of the literature documenting the experimental and clinical research demonstrating the effects of manipulating cGMP for the therapeutic targeting of the injurious effects of ischemic heart disease. Augmentation of the cyclic nucleotide cGMP plays a crucial role in many cardioprotective signaling pathways. There is an extensive body of literature which supports pharmacological targeting of cGMP or upstream activators in ...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 16, 2014 Category: Cardiology Authors: Bice, J. S., Burley, D. S., Baxter, G. F. Tags: Reviews Source Type: research

Regulation of Endothelial Nitric Oxide Synthase and High-Density Lipoprotein Quality by Estradiol in Cardiovascular Pathology
Estrogens have been recognized, in the last 3 decades, as important hormones in direct and indirect modulation of vascular health. In addition to their direct benefit on cardiovascular health, the presence of esterified estrogen in the lipid core of high-density lipoprotein (HDL) particles indirectly contributes to atheroprotection by significantly improving HDL quality and functionality. Estrogens modulate their physiological activity via genomic and nongenomic mechanisms. Genomic mechanisms are thought to be mediated directly by interaction of the hormone receptor complex with the hormone response elements that regulate ...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 16, 2014 Category: Cardiology Authors: Kypreos, K. E., Zafirovic, S., Petropoulou, P.-I., Bjelogrlic, P., Resanovic, I., Traish, A., Isenovic, E. R. Tags: Reviews Source Type: research

A Systematic Review and Meta-Analysis of the Effects of Pycnogenol on Plasma Lipids
Conclusion: Current clinical evidence does not suggest any significant effect of Pycnogenol on fasting lipid profile. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 16, 2014 Category: Cardiology Authors: Sahebkar, A. Tags: Reviews Source Type: research

Role of ATP-Sensitive K+ Channels in Cardiac Arrhythmias
The sarcolemmal adenosine triphosphate (ATP)-sensitive K+ (sarcKATP) channel in the heart is a hetero-octamer comprising the pore-forming subunit Kir6.2 and the regulatory subunit sulfonylurea receptor SUR2A. By functional analysis of genetically engineered mice lacking sarcKATP channels, the pathophysiological roles of the K+ channel in the heart have been extensively evaluated. Although mitochondrial KATP (mitoKATP) channel is proposed to be an important effector for the protection of ischemic myocardium and the inhibition of ischemia/reperfusion-induced ventricular arrhythmias, the molecular identity of mitoKATP channel...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 16, 2014 Category: Cardiology Authors: Nakaya, H. Tags: Reviews Source Type: research

Myocardial Protection Provided by Chronic Skeletal Muscle Ischemia Is Not Further Enhanced by Ischemic Pre- or Postconditioning: Comparative Effects on Intracellular Signaling
In conclusion, chronic skeletal muscle ischemia results in effective cardioprotection, which is not further enhanced with application of PreC or PostC. The Akt, eNOS, GSK3β, p44/42, and STAT3 may only be considered as indicators of the intracellular changes taking place during protection. Activation of STAT5 is possibly the end effector, which is responsible for infarct size reduction provided by chronic skeletal muscle ischemia. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 17, 2014 Category: Cardiology Authors: Bibli, S.-I., Andreadou, I., Lazaris, E., Zoga, A., Varnavas, V., Andreou, C. C., Dagres, N., Iliodromitis, E. K., Kyriakides, Z. S. Tags: Experimental Studies Source Type: research

Characterization of the Adenosine Pharmacology of Ticagrelor Reveals Therapeutically Relevant Inhibition of Equilibrative Nucleoside Transporter 1
Conclusions: Ticagrelor inhibits cellular adenosine uptake selectively via ENT1 inhibition at concentrations of clinical relevance. However, the low-binding affinity and functional inhibition of adenosine receptors observed with ticagrelor or its metabolites indicate that they possess a negligible adenosine-like activity at clinically relevant concentrations. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 17, 2014 Category: Cardiology Authors: Armstrong, D., Summers, C., Ewart, L., Nylander, S., Sidaway, J. E., van Giezen, J. J. J. Tags: Experimental Studies Source Type: research

Clustering of Acute and Subacute Stent Thrombosis Related to the Introduction of Generic Clopidogrel
Conclusions: We observed an unexpected >2-fold increase in ST coincident with generic clopidogrel use. Although we cannot ascribe causality, this observation warrants increased vigilance and close monitoring of patients receiving generic clopidogrel. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 17, 2014 Category: Cardiology Authors: Kovacic, J. C., Mehran, R., Sweeny, J., Li, J. R., Moreno, P., Baber, U., Krishnan, P., Badimon, J. J., Hulot, J.-S., Kini, A., Sharma, S. K. Tags: Clinical Studies Source Type: research

Prevention of Cataracts by Statins: A Meta-Analysis
Conclusion: This meta-analysis indicates a clinically relevant protective effect of statins in preventing cataracts. The effect is more pronounced in younger patients and with longer duration of follow-up, while there is no difference by gender. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 17, 2014 Category: Cardiology Authors: Kostis, J. B., Dobrzynski, J. M. Tags: Clinical Studies Source Type: research

Combined Cardioprotectant and Antithrombotic Actions of Platelet P2Y12 Receptor Antagonists in Acute Coronary Syndrome: Just What the Doctor Ordered
Since the P2Y12 receptor antagonists were first introduced, they have been extensively tested in patients with acute coronary syndrome and are now standard of care. These antiplatelet drugs are very effective in reducing subsequent cardiovascular events, stent thromboses, and mortality in patients with acute myocardial infarction undergoing reperfusion therapy. Although the prevailing view is that their benefit derives from their antithrombotic properties, other unrelated pleiotropic effects appear to be equally beneficial. Accumulating clinical and animal evidence indicates that, if present at the time of reperfusion, the...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 17, 2014 Category: Cardiology Authors: Cohen, M. V., Downey, J. M. Tags: Reviews Source Type: research

Inflammation and Atherosclerosis--Revisited
Atherogenesis has been traditionally viewed as a metabolic disease representing arterial obstruction by fatty deposits in its wall. Today, it is believed that atherogenesis involves highly specific biochemical and molecular responses with constant interactions between various cellular players. Despite the presence of inflammatory reaction in each and every step of atherosclerosis from its inception to terminal manifestation, the cause–effect relationship of these 2 processes remains unclear. In this article, we have attempted to review the role of inflammation in the development of atherosclerosis and in its major co...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 17, 2014 Category: Cardiology Authors: Pant, S., Deshmukh, A., GuruMurthy, G. S., Pothineni, N. V., Watts, T. E., Romeo, F., Mehta, J. L. Tags: Reviews Source Type: research

Update on Pharmacologic Therapy for Pulmonary Embolism
This article will give an overview of the various anticoagulant drugs, use in various clinical scenarios, data supporting their clinical use, and recommendations regarding duration of anticoagulant therapy. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 17, 2014 Category: Cardiology Authors: Harikrishnan, P., Palaniswamy, C., Aronow, W. S. Tags: Reviews Source Type: research