High-Dose Atorvastatin Reloading Before Percutaneous Coronary Intervention Increased Circulating Endothelial Progenitor Cells and Reduced Inflammatory Cytokine Expression During the Perioperative Period

Conclusion:
Our results suggested that high-dose atorvastatin application before PCI triggered early EPC circulation. Furthermore, postoperative inflammatory cytokine sICAM-1 as well as hCRP serum levels were reduced, while postinterventional myocardial injury marker TnI elevations were inversely correlated with statin reloadings.

Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 16, 2014 Category: Cardiology Authors: Ye, H., He, F., Fei, X., Lou, Y., Wang, S., Yang, R., Hu, Y., Chen, X. Tags: Clinical Studies Source Type: research