Myocardial Protection Provided by Chronic Skeletal Muscle Ischemia Is Not Further Enhanced by Ischemic Pre- or Postconditioning: Comparative Effects on Intracellular Signaling

In conclusion, chronic skeletal muscle ischemia results in effective cardioprotection, which is not further enhanced with application of PreC or PostC. The Akt, eNOS, GSK3β, p44/42, and STAT3 may only be considered as indicators of the intracellular changes taking place during protection. Activation of STAT5 is possibly the end effector, which is responsible for infarct size reduction provided by chronic skeletal muscle ischemia.

Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 17, 2014 Category: Cardiology Authors: Bibli, S.-I., Andreadou, I., Lazaris, E., Zoga, A., Varnavas, V., Andreou, C. C., Dagres, N., Iliodromitis, E. K., Kyriakides, Z. S. Tags: Experimental Studies Source Type: research