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Urinary Trypsin Inhibitor Reduced Inflammation Response Induced by Hyperlipidemia
Conclusions: Urinary trypsin inhibitor could reduce neointimal hyperplasia by inhibiting inflammatory response induced by hyperlipidemia and may become a potential antiatherosclerosis supplement. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - October 7, 2015 Category: Cardiology Authors: Deng, Y., Kong, J. Tags: Experimental Studies Source Type: research

Tanshinone IIA Prevents Rat Basilar Artery Smooth Muscle Cells Proliferation by Inactivation of PDK1 During the Development of Hypertension
Basilar vascular smooth muscle cells (BASMCs) hyperplasia is a prominent feature of cerebrovascular remodeling and stroke during the development of hypertension. Tanshinone IIA (Tan) has been reported to exhibit a protective effect against the pathological features of hypertension. Previous studies have shown that phosphoinostitide-3 kinase (PI3K)/3'-phosphoinostitide dependent kinase (PDK1)/AKT pathway is involved in the regulation of proliferation of various cell types. Therefore, there may be a crosstalk between Tan antihypertension processes and PI3K/PDK1/AKT proliferative effect in BASMCs. To test this hypothesis, we ...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - October 7, 2015 Category: Cardiology Authors: Yu, Z.-L., Wang, J.-N., Wu, X.-H., Xie, H.-J., Han, Y., Guan, Y.-T., Qin, Y., Jiang, J.-M. Tags: Experimental Studies Source Type: research

Effects of Rivaroxaban on Platelet Activation and Platelet-Coagulation Pathway Interaction: In Vitro and In Vivo Studies
Conclusion: These data indicate that the combination of rivaroxaban with single or dual antiplatelet agents works synergistically to reduce platelet activation, which may in turn lead to the delayed/reduced formation of coagulation complexes and vice versa, thereby enhancing antithrombotic potency. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - October 7, 2015 Category: Cardiology Authors: Perzborn, E., Heitmeier, S., Laux, V. Tags: Experimental Studies Source Type: research

The Role of Ivabradine in Cardiac Rehabilitation in Patients With Recent Coronary Artery Bypass Graft
Conclusion: Adding ivabradine to low-dose bisoprolol during cardiac rehabilitation in patients with CABG improved functional capacity, enhanced recovery of systolic function, and reduced diastolic dysfunction. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - October 7, 2015 Category: Cardiology Authors: Marazia, S., Urso, L., Contini, M., Pano, M., Zaccaria, S., Lenti, V., Sarullo, F. M., Di Mauro, M. Tags: Clinical Studies Source Type: research

Trimetazidine Decreases Risk of Contrast-Induced Nephropathy in Patients With Chronic Kidney Disease: A Meta-Analysis of Randomized Controlled Trials
Conclusions: The addition of TMZ to NS ± NAC significantly decreased the incidence of CIN in patients undergoing coronary angiography. In conclusion, TMZ could be considered as a potential tool for prevention of CIN in patients with renal dysfunction. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - October 7, 2015 Category: Cardiology Authors: Nadkarni, G. N., Konstantinidis, I., Patel, A., Yacoub, R., Kumbala, D., Patel, R. A. G., Annapureddy, N., Pakanati, K. C., Simoes, P. K., Javed, F., Benjo, A. M. Tags: Clinical Studies Source Type: research

Effects of Pregnane X Receptor Genetic Polymorphisms on Stable Warfarin Doses
Conclusion: Our results revealed that PXR could be a determinant of stable warfarin doses. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - October 7, 2015 Category: Cardiology Authors: Moon, J. Y., Chang, B. C., Lee, K. E., Bang, J. S., Gwak, H. S. Tags: Clinical Studies Source Type: research

Lack of Benefit of Ischemic Postconditioning After Routine Thrombus Aspiration During Reperfusion: Immediate and Midterm Results
Conclusion: In patients with STEMI treated with MTA, PostCon offered no benefits to infarct size, LVEF, or major cardiac events. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - October 7, 2015 Category: Cardiology Authors: Luz, A., Santos, M., Magalhaes, R., Silveira, J., Cabral, S., Dias, V., Oliveira, F., Pereira, S., Leite-Moreira, A., Carvalho, H., Torres, S. Tags: Clinical Studies Source Type: research

Valsartan Promoting Atherosclerotic Plaque Stabilization by Upregulating Renalase: A Potential-Related Gene of Atherosclerosis
Conclusions: Renalase may be a potential-related gene of lipid metabolism and As, and it may be the possible molecular target of valsartan to help stabilize atherosclerotic plaque. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - August 13, 2015 Category: Cardiology Authors: Zhou, M., Ma, C., Liu, W., Liu, H., Wang, N., Kang, Q., Li, P. Tags: Experimental Studies Source Type: research

Atria are More Sensitive Than Ventricles to GS-458967-Induced Inhibition of Late Sodium Current
Conclusion: In canine coronary-perfused preparations, GS-458967 abbreviates APD, induces PRR, and reduces Vmax in atria but has no significant effect on these parameters in the ventricles, indicating an atrial-selective effect of GS-458967 on both peak and late INa-mediated parameters. In multicellular preparations, GS-458967 abbreviated ventricular APD only under long QT conditions, suggesting a pathology-specific action of GS-458967 in canine ventricular myocardium. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - August 13, 2015 Category: Cardiology Authors: Burashnikov, A., Di Diego, J. M., Goodrow, R. J., Belardinelli, L., Antzelevitch, C. Tags: Experimental Studies Source Type: research

Case Fatality Rates of Recurrent Thromboembolism and Bleeding in Patients Receiving Direct Oral Anticoagulants for the Initial and Extended Treatment of Venous Thromboembolism: A Systematic Review
Conclusion: The use of DOACs was associated with fewer major and fatal bleedings and corresponding CFR than standard initial treatment of VTE, and fewer recurrent VTEs and mortality than placebo during extended therapy, although the CFR of recurrent VTE was not reduced. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - August 13, 2015 Category: Cardiology Authors: Gomez-Outes, A., Lecumberri, R., Suarez-Gea, M. L., Terleira-Fernandez, A.-I., Monreal, M., Vargas-Castrillon, E. Tags: Clinical Studies Source Type: research

A Multidose Study to Examine the Effect of Food on Evacetrapib Exposure at Steady State
Conclusion: A high-fat meal increased evacetrapib mean exposure at steady state by 44% in healthy participants. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - August 13, 2015 Category: Cardiology Authors: Small, D. S., Zhang, W., Royalty, J., Cannady, E. A., Downs, D., Friedrich, S., Suico, J. G. Tags: Clinical Studies Source Type: research

pCMV-vegf165 Intramuscular Gene Transfer is an Effective Method of Treatment for Patients With Chronic Lower Limb Ischemia
Effective treatment of chronic lower limb ischemia is one of the most challenging issues confronting vascular surgeons. There are a number of choices available to the vascular surgeon. Open or endovascular revascularization is the treatment of choice when applicable. Current pharmacological therapies play an auxiliary role and cannot prevent disease progression. Therefore, new methods of treatment are needed. We conducted a phase 2b/3 multicenter randomized controlled clinical trial of the intramuscular transfer of a plasmid DNA encoding vascular endothelial growth factor (VEGF) 165 with cytomegalovirus promotor (CMV) in p...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - August 13, 2015 Category: Cardiology Authors: Deev, R. V., Bozo, I. Y., Mzhavanadze, N. D., Voronov, D. A., Gavrilenko, A. V., Chervyakov, Y. V., Staroverov, I. N., Kalinin, R. E., Shvalb, P. G., Isaev, A. A. Tags: Clinical Studies Source Type: research

Atorvastatin Reduces the Incidence of Postoperative Atrial Fibrillation in Statin-Naive Patients Undergoing Isolated Heart Valve Surgery: A Double-Blind, Placebo-Controlled Randomized Trial
Conclusion: Perioperative treatment with 40 mg of atorvastatin is useful to decrease the incidence of POAF in the statin-naive patients undergoing isolated heart valve surgery. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - August 13, 2015 Category: Cardiology Authors: Dehghani, M. R., Kasianzadeh, M., Rezaei, Y., Sepehrvand, N. Tags: Clinical Studies Source Type: research

Periprocedural Management of New Oral Anticoagulants in Atrial Fibrillation Ablation
This article reviews the literature in PubMed from 1998 to 2014 and includes clinical trials and meta-analysis that analyzed the safety and efficacy of NOACs during AF catheter ablation. Dabigatran seems to be as effective and safe as warfarin, although most data are from single-center studies, with small samples and very low overall bleeding and thromboembolic complications. Periprocedural anticoagulation protocols also vary greatly between studies. Some recent meta-analysis has shown that warfarin could still be a safer and more effective alternative. There are fewer studies with rivaroxaban in AF ablation, and there hav...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - August 13, 2015 Category: Cardiology Authors: Zak, M., Castiblanco, S. A., Garg, J., Palaniswamy, C., Jacobs, L. E. Tags: Review Articles Source Type: research

Statins and Nonadherence: Should We RELATE Better?
Statin nonadherence is a major challenge to optimal management. Patients nonadherent to statin therapy do not receive the expected benefit relative to the degree of low-density lipoprotein cholesterol (LDL-C) lowering obtained. This is important because new evidence guidelines recommend statins as the first-line therapy for those in high-risk groups (secondary prevention, patients with diabetes 40-75 years of age, and LDL-C ≥ 190 mg/dL) and in selected primary prevention patients. Statin assignment in the latter group occurs only in those with an estimated ≥7.5% 10-year atherosclerotic cardiovascular disease risk aft...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - August 13, 2015 Category: Cardiology Authors: Turin, A., Pandit, J., Stone, N. J. Tags: Review Articles Source Type: research