Atria are More Sensitive Than Ventricles to GS-458967-Induced Inhibition of Late Sodium Current

Conclusion:
In canine coronary-perfused preparations, GS-458967 abbreviates APD, induces PRR, and reduces Vmax in atria but has no significant effect on these parameters in the ventricles, indicating an atrial-selective effect of GS-458967 on both peak and late INa-mediated parameters. In multicellular preparations, GS-458967 abbreviated ventricular APD only under long QT conditions, suggesting a pathology-specific action of GS-458967 in canine ventricular myocardium.

Source: Journal of Cardiovascular Pharmacology and Therapeutics - August 13, 2015 Category: Cardiology Authors: Burashnikov, A., Di Diego, J. M., Goodrow, R. J., Belardinelli, L., Antzelevitch, C. Tags: Experimental Studies Source Type: research