Journal of Cardiovascular Pharmacology and Therapeutics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Electrophysiological Characterization and Antiarrhythmic Efficacy of the Mixed Potassium Channel-Blocking Antiarrhythmic Agent AZ13395438 In Vitro and In Vivo
Conclusion: AZ13395438 can be characterized as a mixed potassium ion channel-blocking agent that selectively prolongs atrial versus ventricular refractoriness and shows promising antiarrhythmic efficacy in a clinically relevant animal model of AF. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 11, 2013 Category: Cardiology Authors: Jacobson, I., Duker, G., Florentzson, M., Linhardt, G., Lindhardt, E., Nordkam, A.-K., Astrand, A., Carlsson, L. Tags: Experimental Studies Source Type: research

Probenecid as a Noninjurious Positive Inotrope in an Ischemic Heart Disease Murine Model
In conclusion, we provide novel data that probenecid, through its activity on cellular Ca2+ levels, induces an inotropic effect without causing or exacerbating injury. This discovery may be translatable if this mechanism is preserved in man. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 11, 2013 Category: Cardiology Authors: Koch, S. E., Tranter, M., Robbins, N., Luther, K., Singh, U., Jiang, M., Ren, X., Tee, T., Smith, L., Varma, P., Jones, W. K., Rubinstein, J. Tags: Experimental Studies Source Type: research

Intramyocardial Injection of Heart Tissue-Derived Extracellular Matrix Improves Postinfarction Cardiac Function in Rats
Conclusions: Implantation of heart tissue-derived decellularized matrix thickens the LV infarcted wall, prevents paradoxical LV systolic bulging, and improves LV EF after myocardial infarction in rats. This benefit was not dependent on the enhanced angiogenesis or the recruitment of endogenous stem cells to the injury site. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 11, 2013 Category: Cardiology Authors: Dai, W., Gerczuk, P., Zhang, Y., Smith, L., Kopyov, O., Kay, G. L., Jyrala, A. J., Kloner, R. A. Tags: Experimental Studies Source Type: research

Glimepiride Treatment Facilitates Ischemic Preconditioning in the Diabetic Heart
Conclusions: We report for the first time that glimepiride treatment facilitates the cardioprotective effect elicited by IPC in the diabetic heart. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 11, 2013 Category: Cardiology Authors: Hausenloy, D. J., Wynne, A. M., Mocanu, M. M., Yellon, D. M. Tags: Experimental Studies Source Type: research

Platelet P2Y12 Blockers Confer Direct Postconditioning-Like Protection in Reperfused Rabbit Hearts
Conclusions: Clopidogrel and cangrelor protected rabbit hearts against infarction. The mechanism appears to involve signal transduction during reperfusion rather than inhibition of intravascular coagulation. We hypothesize that both drugs protect by activating IPOC’s protective signaling to prevent reperfusion injury. If true, patients receiving P2Y12 inhibitors before percutaneous intervention may already be postconditioned thus explaining failure of recent clinical trials of postconditioning drugs. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 11, 2013 Category: Cardiology Authors: Yang, X.-M., Liu, Y., Cui, L., Yang, X., Liu, Y., Tandon, N., Kambayashi, J., Downey, J. M., Cohen, M. V. Tags: Experimental Studies Source Type: research

The Impact of Cardiovascular Disease and Risk Factor Treatment on Ethnic Disparities in Kidney Transplant
There is limited data on the use of cardiovascular disease (CVD) risk factor medications following renal transplant, especially when comparing use across ethnicities. The aim of this study was to compare the incidence, treatment, and impact of CVD between ethnicities in kidney transplant recipients. This was a retrospective cohort study of adults who underwent transplant between 2000 and 2008 within our academic medical transplant center. Pediatrics, multiorgan transplants, and those lost to follow-up were excluded. Data collection included all transplant and sociodemographic characteristics, medication use, CVD risk facto...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 11, 2013 Category: Cardiology Authors: Taber, D. J., Pilch, N. A., Meadows, H. B., McGillicuddy, J. W., Bratton, C. F., Chavin, K. D., Baliga, P. K., Egede, L. E. Tags: Clinical Studies Source Type: research

Lipid-Lowering Pharmacotherapy in Central and Eastern European Countries in Cardiovascular Prevention: Self-Reported Prescription Patterns of Primary Care Physicians
Conclusions: There are significant variations in the use of lipid-lowering drugs in Central and Eastern European countries; however, statin monotherapy predominates. Some physicians’ decisions are made without supporting evidence from clinical trials. There is still scope to improve preventive care of CVD. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 11, 2013 Category: Cardiology Authors: Tomasik, T., Windak, A., Seifert, B., Kersnik, J., Kijowska, V., Dubas, K. Tags: Clinical Studies Source Type: research

Effect of Simvastatin/Ezetimibe 10/10 mg Versus Simvastatin 40 mg on Serum Vitamin D Levels
Conclusion: For similar LDL-C lowering simvastatin 40 mg is associated with greater increase in 25(OH)VitD compared to simvastatin/ezetimibe 10/10 mg. Whether this difference is relevant in terms of CVD risk reduction is unknown. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 11, 2013 Category: Cardiology Authors: Liberopoulos, E. N., Makariou, S. E., Moutzouri, E., Kostapanos, M. S., Challa, A., Elisaf, M. Tags: Clinical Studies Source Type: research

Efficacy and Safety of Adjunctive Cilostazol to Dual Antiplatelet Therapy After Stent Implantation: An Updated Meta-Analysis of Randomized Controlled Trials
Conclusions: When compared to the currently recommended DAT, triple antiplatelet therapy with cilostazol can reduce repeat revascularization with no increase in the risk of bleeding. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 11, 2013 Category: Cardiology Authors: Ding, X. L., Xie, C., Jiang, B., Gao, J., Zhang, L. L., Zhang, H., Zhang, J. J., Miao, L. Y. Tags: Clinical Studies Source Type: research

Aspirin Increases Nitric Oxide Formation in Chronic Stable Coronary Disease
Conclusions: In patients with chronic stable coronary disease, all clinically relevant daily doses of aspirin tested, from 81 to 1300 mg, produce similar and statistically significant increases in HO-1 and decreases in ADMA. These are the first randomized data on secondary prevention patients. These data support the hypothesis that aspirin has additional beneficial effects mediated through NO formation. Further research, including direct randomized comparisons on atherosclerosis using noninvasive techniques as well as on occlusive vascular disease events, is necessary. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 11, 2013 Category: Cardiology Authors: Hetzel, S., DeMets, D., Schneider, R., Borzak, S., Schneider, W., Serebruany, V., Schroder, H., Hennekens, C. H. Tags: Clinical Studies Source Type: research

Acute and Chronic Effects of Glyceryl Trinitrate Therapy on Insulin and Glucose Regulation in Humans
This study examined the effect of acute and sustained transdermal glyceryl trinitrate (GTN) therapy on insulin and glucose regulation. Totally, 12 males (18-30 years) underwent a glucose tolerance test at baseline (visit 1), 90 minutes after acute transdermal GTN 0.6 mg/h (visit 2), following 7 days of continuous GTN (visit 3), and 2 to 3 days after stopping GTN (visit 4). At each visit, plasma glucose and insulin concentrations were measured before and 30, 60, 90, and 120 minutes after a 75-g oral glucose load. Indices of glucose metabolism that were examined included the insulin sensitivity index, the homeostasis model a...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 11, 2013 Category: Cardiology Authors: Jedrzkiewicz, S., Parker, J. D. Tags: Clinical Studies Source Type: research

Low-Density Lipoprotein Lowering in 2013 by Nonstatin Agents: The Discovery and Development of Promising Novel Targeted Therapies
Dyslipidemia is a major risk factor for the development of coronary artery disease, a leading cause of morbidity and mortality worldwide. Lowering low-density lipoprotein (LDL) has significantly reduced the risk of death and other major cardiovascular events, and statins remain the therapy of choice. However, as some patients are limited by the side effects of statins, cannot achieve their target LDL on statin therapy, or have other abnormalities in their lipid profile, alternative agents are being developed. In this review, we highlight the major classes of novel nonstatin LDL-lowering agents that are currently in various...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 11, 2013 Category: Cardiology Authors: Kohli, P., Giugliano, R. P. Tags: Review Article Source Type: research

A Brief Review of Useful Tips for Publishing Your Scientific Manuscript
(Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 11, 2013 Category: Cardiology Authors: Kloner, R. A. Tags: Editorial Source Type: research

Protective Effect of K201 on Isoproterenol-Induced and Ischemic-Reperfusion-Induced Ventricular Arrhythmias in the Rat: Comparison With Diltiazem
Aim: Ventricular arrhythmia (VA) is a risk for sudden death. Polymorphic ventricular tachycardia (VT) degenerating to ventricular fibrillation occurs subsequent to the prolongation of the QT interval following administration of catecholamines under Ca2+ loading. Fatal VA also occurs in ischemia and ischemic–reperfusion. We compared the suppressive effect of K201 (JTV519), a multiple-channel blocker and cardiac ryanodine receptor-calcium release channel (RyR2) stabilizer, with that of diltiazem, a Ca2+ channel blocker, in 2 studies of isoproterenol-induced (n = 30) and ischemic–reperfusion-induced VAs (n = 38) i...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 4, 2013 Category: Cardiology Authors: Otani, N., Matsuda, R., Oda, K., Nishino, S., Inoue, T., Kaneko, N. Tags: Experimental Studies Source Type: research

Treatment With Low-dose Atorvastatin, Losartan, and Their Combination Increases Expression of Vasoactive-Related Genes in Rat Aortas
Recently it has been shown that statins and angiotensin receptor blockers (ARBs) at low doses express beneficial pleiotropic vascular effects. We aimed to explore whether these drugs at low doses induce the expression of vasoactive-related genes. Sixty adult Wistar rats were treated with low-dose atorvastatin (2 mg/kg), low-dose losartan (5 mg/kg), their combination or saline daily for 4, 6, or 8 weeks. Expression of the vasoactive-related genes endothelin receptor type A (EDNRA), endothelial nitric oxide synthase 3 (NOS3), inducible nitric oxide synthase 2 (NOS2), and angiotensin II receptor type 1 (AGTRL1a) was measured ...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 4, 2013 Category: Cardiology Authors: Lunder, M., Drevensek, G., Cerne, D., Marc, J., Janic, M., Sabovic, M. Tags: Experimental Studies Source Type: research