Aspirin Increases Nitric Oxide Formation in Chronic Stable Coronary Disease

Conclusions:
In patients with chronic stable coronary disease, all clinically relevant daily doses of aspirin tested, from 81 to 1300 mg, produce similar and statistically significant increases in HO-1 and decreases in ADMA. These are the first randomized data on secondary prevention patients. These data support the hypothesis that aspirin has additional beneficial effects mediated through NO formation. Further research, including direct randomized comparisons on atherosclerosis using noninvasive techniques as well as on occlusive vascular disease events, is necessary.

Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 11, 2013 Category: Cardiology Authors: Hetzel, S., DeMets, D., Schneider, R., Borzak, S., Schneider, W., Serebruany, V., Schroder, H., Hennekens, C. H. Tags: Clinical Studies Source Type: research