Probenecid as a Noninjurious Positive Inotrope in an Ischemic Heart Disease Murine Model

In conclusion, we provide novel data that probenecid, through its activity on cellular Ca2+ levels, induces an inotropic effect without causing or exacerbating injury. This discovery may be translatable if this mechanism is preserved in man.

Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 11, 2013 Category: Cardiology Authors: Koch, S. E., Tranter, M., Robbins, N., Luther, K., Singh, U., Jiang, M., Ren, X., Tee, T., Smith, L., Varma, P., Jones, W. K., Rubinstein, J. Tags: Experimental Studies Source Type: research