Intramyocardial Injection of Heart Tissue-Derived Extracellular Matrix Improves Postinfarction Cardiac Function in Rats

Conclusions: Implantation of heart tissue-derived decellularized matrix thickens the LV infarcted wall, prevents paradoxical LV systolic bulging, and improves LV EF after myocardial infarction in rats. This benefit was not dependent on the enhanced angiogenesis or the recruitment of endogenous stem cells to the injury site.

http://cpt.sagepub.com/cgi/content/abstract/18/3/270?rss=1

Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 11, 2013 Category: Cardiology Authors: Dai, W., Gerczuk, P., Zhang, Y., Smith, L., Kopyov, O., Kay, G. L., Jyrala, A. J., Kloner, R. A. Tags: Experimental Studies Source Type: research