Electrophysiological Characterization and Antiarrhythmic Efficacy of the Mixed Potassium Channel-Blocking Antiarrhythmic Agent AZ13395438 In Vitro and In Vivo

Conclusion:
AZ13395438 can be characterized as a mixed potassium ion channel-blocking agent that selectively prolongs atrial versus ventricular refractoriness and shows promising antiarrhythmic efficacy in a clinically relevant animal model of AF.

Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 11, 2013 Category: Cardiology Authors: Jacobson, I., Duker, G., Florentzson, M., Linhardt, G., Lindhardt, E., Nordkam, A.-K., Astrand, A., Carlsson, L. Tags: Experimental Studies Source Type: research