Journal of Cardiovascular Pharmacology and Therapeutics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Rosuvastatin Changes Cytokine Expressions in Ischemic Territory and Preserves Heart Function After Acute Myocardial Infarction in Rats
Conclusion: The data suggest that rosuvastatin can protect the heart from ischemic injury and preserve the cardiac function in rats in vivo. The changing expressions of SDF-1, CXCR-4, ICAM-1, and VEGF, and the accumulation of progenitor cells were involved in this process. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 4, 2013 Category: Cardiology Authors: Hu, X., Sun, A., Xie, X., Huang, Z., Jia, J., Yao, R., Ge, J. Tags: Experimental Studies Source Type: research

Mast Cell Inhibition Attenuates Myocardial Damage, Adverse Remodeling, and Dysfunction During Fulminant Myocarditis in the Rat
Conclusions: Our study suggests that mast cell inhibition with cromolyn sodium attenuates adverse LV remodeling and dysfunction in myocarditis. This mechanism-based therapy is clinically relevant and could improve the outcome of patients at risk for inflammatory cardiomyopathy and heart failure. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 4, 2013 Category: Cardiology Authors: Mina, Y., Rinkevich-Shop, S., Konen, E., Goitein, O., Kushnir, T., Epstein, F. H., Feinberg, M. S., Leor, J., Landa-Rouben, N. Tags: Experimental Studies Source Type: research

Enhanced Angiotensin II-Induced Cardiac and Aortic Remodeling in ACE2 Knockout Mice
Angiotensin-converting enzyme 2 (ACE2) is present in the heart and thought to exert protective functions. We conducted studies in ACE2 deficient mice to determine whether enzyme loss would exacerbate the cardiac and vascular pathological responses to chronic subcutaneous (sc) angiotensin II (Ang II) infusion. Eight-week-old male ACE2 knockout (KO) and wild type (WT) mice were infused with Ang II (1000 ng/kg per min, 4 weeks) using mini-osmotic pumps. Blood pressure (radiotelemetry), cardiac function (echocardiography, echo), cardiac/aortic structure (histology, collagen, and oxidative stress), and vascular inflammation wer...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 4, 2013 Category: Cardiology Authors: Alghamri, M. S., Weir, N. M., Anstadt, M. P., Elased, K. M., Gurley, S. B., Morris, M. Tags: Experimental Studies Source Type: research

Upregulation of {beta}3-Adrenergic Receptor Expression in the Atrium of Rats With Chronic Heart Failure
Conclusion: There is a significant increase in the β3-AR mRNA expression in the atrium of rats with heart failure. The level of β3-AR mRNA expression was associated with the AMI and was enhanced by a selective β3-AR agonist, BRL-37344. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 4, 2013 Category: Cardiology Authors: Zhao, Q., Zeng, F., Liu, J.-B., He, Y., Li, B., Jiang, Z.-F., Wu, T.-G., Wang, L.-X. Tags: Experimental Studies Source Type: research

Telmisartan Prevents Excess-Salt-Induced Exacerbated (Malignant) Hypertension in Spontaneously Hypertensive Rats
The effects of angiotensin receptor blocker, diuretic, a calcium antagonist, and their combination were evaluated on the progression of cardiovascular and renal damage in spontaneously hypertensive rats (SHRs) given excess salt. To this end, 8-week male SHRs were divided into 7 groups. The control group (C) received normal NaCl (0.6%) diet. All other groups were given 8% NaCl rat chow. In addition, group 2 was given placebo (tap water alone), group 3 the angiotensin receptor antagonist telmisartan (10 mg/kg per d), group 4 received the diuretic chlorothiazide (80 mg/kg per d), group 5 was given telmisartan plus the diureti...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 4, 2013 Category: Cardiology Authors: Susic, D., Fares, H., Frohlich, E. D. Tags: Experimental Studies Source Type: research

Intensive-Dose Atorvastatin Regimen Halts Progression of Atherosclerotic Plaques in New-onset Unstable Angina With Borderline Vulnerable Plaque Lesions
To compare the therapeutic effects of intensive versus moderate dosage of atorvastatin regimens in new-onset unstable angina with borderline lesions, 100 patients were randomized to receive either 80 mg/d or 20 mg/d atorvastatin for 9 months. Clinical symptoms, lipid profiles, and coronary stenosis (evaluated by coronary angiography and intravascular ultrasound) were compared to their corresponding baselines within each group and between the 2 groups after 9 months of treatment. The results showed that (1) when compared to their corresponding baselines, both groups exhibited improvement in clinical symptoms, a significant ...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 4, 2013 Category: Cardiology Authors: Zhang, X., Wang, H., Liu, S., Gong, P., Lin, J., Lu, J., Qiu, J., Lu, X. Tags: Clinical Studies Source Type: research

Effects of Manidipine Plus Rosuvastatin Versus Olmesartan Plus Rosuvastatin on Markers of Insulin Resistance in Patients With Impaired Fasting Glucose, Hypertension, and Mixed Dyslipidemia
Conclusion: Manidipine seems to ameliorate the possible statin-associated increase in insulin resistance as compared with olmesartan in patients with IFG, hypertension, and mixed dyslipidemia. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 4, 2013 Category: Cardiology Authors: Liberopoulos, E. N., Moutzouri, E., Rizos, C. V., Barkas, F., Liamis, G., Elisaf, M. S. Tags: Clinical Studies Source Type: research

Stable Cystatin C Serum Levels Confirm Normal Renal Function in Patients With Dronedarone-Associated Increase in Serum Creatinine
In conclusion, cystatin C represents an easily available and reliable biomarker for estimation of true renal function in patients on dronedarone treatment. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 4, 2013 Category: Cardiology Authors: Duncker, D., Oswald, H., Gardiwal, A., Lusebrink, U., Konig, T., Schreyer, H., Klein, G. Tags: Clinical Studies Source Type: research