Mast Cell Inhibition Attenuates Myocardial Damage, Adverse Remodeling, and Dysfunction During Fulminant Myocarditis in the Rat

Conclusions:
Our study suggests that mast cell inhibition with cromolyn sodium attenuates adverse LV remodeling and dysfunction in myocarditis. This mechanism-based therapy is clinically relevant and could improve the outcome of patients at risk for inflammatory cardiomyopathy and heart failure.

Source: Journal of Cardiovascular Pharmacology and Therapeutics - February 4, 2013 Category: Cardiology Authors: Mina, Y., Rinkevich-Shop, S., Konen, E., Goitein, O., Kushnir, T., Epstein, F. H., Feinberg, M. S., Leor, J., Landa-Rouben, N. Tags: Experimental Studies Source Type: research