Journal of Cardiovascular Pharmacology and Therapeutics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Information for Authors
(Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 17, 2015 Category: Cardiology Tags: Information for Authors Source Type: research

Hyperbaric Oxygen Preconditioning Attenuates Myocardium Ischemia-Reperfusion Injury Through Upregulation of Heme Oxygenase 1 Expression: PI3K/Akt/Nrf2 Pathway Involved
Conclusion: These data present a novel signaling mechanism by which hyperbaric oxygen preconditioning protects myocardium ischemia-reperfusion injury via PI3K/Akt/Nrf2-dependent antioxidant defensive system. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 17, 2015 Category: Cardiology Authors: Yin, X., Wang, X., Fan, Z., Peng, C., Ren, Z., Huang, L., Liu, Z., Zhao, K. Tags: Experimental Studies Source Type: research

Effects of Dantrolene Treatment on Ventricular Electrophysiology and Arrhythmogenesis in Rats With Chronic {beta}-Adrenergic Receptor Activation
In this study, the effects of dantrolene treatment on electrophysiological properties and ventricular arrhythmias (VAs) in rats with chronic β-adrenergic receptor (β-AR) activation were investigated. Rats were randomized to treatment with saline (control group), isoproterenol (ISO; ISO group), or ISO + dantrolene (ID group) for 2 weeks. An electrophysiological study was performed to assess action potential duration restitution (APDR) and induce action potential duration (APD) alternans or VA in vitro. The protein levels of Cav1.2, sarcoplasmic reticulum Ca2+-ATPase (SERCA2a), and ryanodine receptor 2 (RyR2) were ...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 17, 2015 Category: Cardiology Authors: Liu, T., Shi, S.-b., Qin, M., Huang, C.-x. Tags: Experimental Studies Source Type: research

Minor Changes in Core Temperature Prior to Cardiac Arrest Influence Outcomes: An Experimental Study
Conclusion: Small changes in body temperature prior to asphyxial CA significantly influence brain mitochondrial functions and short-term outcomes in rabbits. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 17, 2015 Category: Cardiology Authors: Cour, M., Jahandiez, V., Loufouat, J., Ovize, M., Argaud, L. Tags: Experimental Studies Source Type: research

Nicorandil Versus Nitroglycerin for Symptomatic Relief of Angina in Patients With Slow Coronary Flow Phenomenon: A Randomized Clinical Trial
Conclusion: In slow flow patients, nicorandil provides better symptomatic relief of angina than nitroglycerin. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 17, 2015 Category: Cardiology Authors: Sani, H. D., Eshraghi, A., Nezafati, M. H., Vojdanparast, M., Shahri, B., Nezafati, P. Tags: Clinical Studies Source Type: research

Predicting the Need for Upfront Combination Therapy in Pulmonary Arterial Hypertension
Conclusion: Patients with PAH who require combination therapy in the course of their disease have worse hemodynamics, PAH risk score, functional class, and end of 6MWT oxygen saturation at the time of presentation compared to patients maintained on monotherapy. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 17, 2015 Category: Cardiology Authors: Bajwa, A. A., Qureshi, T., Shujaat, A., Seeram, V., Jones, L. M., Al-Saffar, F., Cury, J. D. Tags: Clinical Studies Source Type: research

Genotype-Guided Dosing of Coumarin Anticoagulants: A Meta-analysis of Randomized Controlled Trials
Conclusions: This meta-analysis showed that genotype-guided dosing increased the effectiveness and safety of coumarin therapy compared with standard dosing but did not have advantages compared with clinical variables-guided dosing. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 17, 2015 Category: Cardiology Authors: Tang, T., Liu, J., Zuo, K., Cheng, J., Chen, L., Lu, C., Han, S., Xu, J., Jia, Z., Ye, M., Pei, E., Zhang, X., Li, M. Tags: Clinical Studies Source Type: research

Patterns of Antiplatelet Therapy in Patients Who Have Experienced an Acute Coronary Event: A Descriptive Study in UK Primary Care
Conclusion: Although most patients were prescribed AP therapy in the 90 days following an acute coronary event, a substantial proportion discontinued DAT or ASA monotherapy within 1 year. It is essential that physicians consider strategies to reduce the risk of discontinuation of AP therapy. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 17, 2015 Category: Cardiology Authors: Saez, M. E., Gonzalez-Perez, A., Johansson, S., Nagy, P., Rodriguez, L. A. G. Tags: Clinical Studies Source Type: research

Antiplatelet Therapy Considerations in Ischemic Cardiogenic Shock: Implications of Metabolic Bioactivation
Dual antiplatelet therapy with aspirin and a P2Y12 receptor antagonist remains a mainstay in the prevention of ischemic events following coronary stent placement. Significant controversy exists regarding the optimal management of high platelet reactivity despite antiplatelet therapy; however this finding has been consistently associated with poor clinical outcomes including greater risk of stent thrombosis and myocardial infarction. Variability in antiplatelet effects of clopidogrel and prasugrel has been linked to genetic polymorphisms and potential drug–drug interactions. Both of these factors have significant infl...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 17, 2015 Category: Cardiology Authors: Weeks, P. A., Sieg, A., Paruthi, C., Rajapreyar, I. Tags: Review Articles Source Type: research

What is Wrong With Cardiac Conditioning? We May be Shooting at Moving Targets
Early recanalization of the occluded culprit coronary artery clearly reduces infarct size in both animal models and patients and improves clinical outcomes. Unfortunately, reperfusion can seldom be accomplished before some myocardium infarcts. As a result there has been an intensive search for interventions that will make the heart resistant to infarction so that reperfusion could salvage more myocardium. A number of interventions have been identified in animal models, foremost being ischemic preconditioning. It protects by activating signaling pathways that prevent lethal permeability transition pores from forming in the ...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 17, 2015 Category: Cardiology Authors: Iliodromitis, E. K., Cohen, M. V., Dagres, N., Andreadou, I., Kremastinos, D. T., Downey, J. M. Tags: Review Articles Source Type: research

Response to Letter on "Statins Use and Risk of Cataracts: Firm Conclusions Are Still Far Off"
(Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 15, 2015 Category: Cardiology Authors: Kostis, J. B., Dobrzynski, J. M. Tags: Letters to the Editor Source Type: research

Statins Use and Risk of Cataracts: Firm Conclusions Are Still Far Off
(Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 15, 2015 Category: Cardiology Authors: Saint-Gerons, D. M., Honrubia, C. d. l. F., Montero, D., Gonzalez-Bermejo, D., Andres-Trelles, F. d., Catala-Lopez, F. Tags: Letters to the Editor Source Type: research

Bramah N. Singh, MD, DPhil, DSc: A Tribute
(Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 15, 2015 Category: Cardiology Authors: Naccarelli, G. V. Tags: Tribute Source Type: research

Carbon Monoxide-Releasing Molecules Attenuate Postresuscitation Myocardial Injury and Protect Cardiac Mitochondrial Function by Reducing the Production of Mitochondrial Reactive Oxygen Species in a Rat Model of Cardiac Arrest
The objective of this study is to examine whether carbon monoxide-releasing molecules (CORMs) can decrease the generation of excessive reactive oxygen species (ROS) in cardiac mitochondria, thereby protecting against postresuscitation myocardial injury and cardiac mitochondrial dysfunction after resuscitation in a rat model of ventricular fibrillation (VF), and further investigated the underlying mechanism. Rats suffered 8 minutes of untreated VF and resuscitation and were randomized into the control group with vehicle infusion and the CORM group with CO-releasing molecule 2 (CORM2) treatment. Animals in the Sham group wer...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 15, 2015 Category: Cardiology Authors: Yao, L., Wang, P., Chen, M., Liu, Y., Zhou, L., Fang, X., Huang, Z. Tags: Experimental Studies Source Type: research

Hydroxybutyl Chitosan Polymer-Mediated CD133 Antibody Coating of Metallic Stents to Reduce Restenosis in a Porcine Model of Atherosclerosis
In this study, HBC was explored for the immobilization of anti-CD133 antibodies. We demonstrated that CD133 antibodies mediated by HBC were successfully coated on cobalt–chromium alloy discs and metal stents. The coating was homogeneous and smooth as shown by electronic microscopy analysis. Balloon expansion of coated stents did not cause cracking or peeling. The HBC discs promoted CD133+ EPCs and human umbilical vein endothelial cell growth in vitro. The CD133 antibody-coated but not bare discs bound CD133+ EPCs in vitro. Implantation of CD133 antibody-coated stents significantly inhibited intimal hyperplasia and re...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 15, 2015 Category: Cardiology Authors: Li, J., Zhang, Q., Li, D., An, Y., Kutryk, M. B. J. Tags: Experimental Studies Source Type: research