Journal of Cardiovascular Pharmacology and Therapeutics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Traditional Heart Failure Medications and Sudden Cardiac Death Prevention: A Review
This article will review the data on the effects of traditional heart failure medications, especially β-blockers, Renin Angiotensin system blockers, as well as Statin therapy on sudden cardiac death in post MI patients and in patients with systolic heart failure. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - August 12, 2013 Category: Cardiology Authors: Al Chekakie, M. O. Tags: Review Article Source Type: research

Lipid-Lowering Agents
The role of lipid lowering in reducing the risk of mortality and morbidity from cardiovascular disease (CVD) is well established. Treatment particularly aimed at decreasing low-density lipoprotein cholesterol (LDL-C) is effective in reducing the risk of death from coronary heart disease and stroke. Statins form the cornerstone of treatment. However, in some individuals with a high risk of CVD who are unable to achieve their target LDL-C due to either intolerance or lack of efficacy, there is the need for alternative therapies. This review provides an overview of the different classes of currently available lipid-lowering m...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - August 12, 2013 Category: Cardiology Authors: Ewang-Emukowhate, M., Wierzbicki, A. S. Tags: Cardiovascular Pharmacology Core Review Source Type: research

RETRACTED: The Effect of Coenzyme A Capsule on Serum Triglyceride Concentration inPatients With Hypertriglyceridemia: Results of a Multicenter Clinical Trial
Retraction notice for "The Effect of Coenzyme A Capsule on Serum Triglyceride Concentration in Patients with Hypertriglyceridemia: Results of a Multicenter Clinical Trial" by Tianming Xuan, Bifeng Wu, Yunpeng Shang, Jiangtao Lai, Xiaosheng Hu, Zhong Liu, and Junzhu Chen The article has been retracted due to its earlier publication in substantially similar form as follows: Effect and Safety of coenzyme A on Hyperlipidemia by Zhao Shu-ping, Chen Ya-qin, Chen Jun-zhu, Lai Jiang-tao, published in the Chinese Journal of New Drugs and Clinical Remedies; 2012:242-245. The Effects of Coenzyme A on Serum Lipids in Patients Wi...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - August 12, 2013 Category: Cardiology Tags: Retraction Source Type: research

Cardioprotective Effect of Calcitriol on Myocardial Injury Induced by Isoproterenol in Rats
Conclusions This study provides evidence that CAL ameliorated cardiac hypertrophy, interstitial fibrosis, and oxidative stress in ISO-induced cardiac injury and might play a vital cardioprotective role in such injuries. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 12, 2013 Category: Cardiology Authors: Wang, X., Zhu, Y., Wang, X., Yang, Y., Cheng, S. Tags: Experimental Studies Source Type: research

Effects of Pre- and Postconditioning on Arrhythmogenesis in the In Vivo Rat Model
The antiarrhythmic potential of postconditioning in in vivo models remains poorly defined. We compared the effects of pre- and postconditioning on ventricular arrhythmogenesis against controls with and without reperfusion. Wistar rats (n = 40, 269 ± 3 g) subjected to ischemia (30 minutes)–reperfusion (24 hours) were assigned to the following groups: (1) preconditioning (2 cycles), (2) postconditioning (6 cycles), or (3) no intervention and were compared with (4) nonreperfused infarcts and (5) sham-operated animals. Infarct size was measured, and arrhythmogenesis was evaluated with continuous telemetric electro...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 12, 2013 Category: Cardiology Authors: Kolettis, T. M., Vilaeti, A. D., Tsalikakis, D. G., Zoga, A., Valenti, M., Tzallas, A. T., Papalois, A., Iliodromitis, E. K. Tags: Experimental Studies Source Type: research

A Model of Hypoxia-Reoxygenation on Isolated Adult Mouse Cardiomyocytes: Characterization, Comparison With Ischemia-Reperfusion, and Application to the Cardioprotective Effect of Regular Treadmill Exercise
In conclusion, this H/R model of cardiomyocytes freshly isolated from adult mice shows similar characteristics to the in vivo ischemia-reperfusion conditions. The comparison of in vivo and in vitro settings represents a powerful approach to investigate cardioprotective strategies and to distinguish between direct and indirect cardiomyocyte-dependent mechanisms. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 12, 2013 Category: Cardiology Authors: Portal, L., Martin, V., Assaly, R., d'Anglemont de Tassigny, A., Michineau, S., Berdeaux, A., Ghaleh, B., Pons, S. Tags: Experimental Studies Source Type: research

Sunitinib, a Small-Molecule Receptor Tyrosine Kinase Inhibitor, Suppresses Neointimal Hyperplasia in Balloon-Injured Rat Carotid Artery
The migration and proliferation of vascular smooth muscle cells (VSMCs) induced by growth factors play a critical role in in-stent stenosis after percutaneous coronary intervention (PCI). The present study tested the hypothesis that sunitinib malate (sunitinib), a tyrosine kinase inhibitor of multiple receptors for growth factors, can reduce neointimal formation after arterial injury in vivo and sought to reveal the underlying mechanism in vitro. Male Wistar rats with balloon-injured carotid arteries were administered either sunitinib or a vehicle orally for 2 weeks. Sunitinib significantly inhibited neointimal hyperplasia...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 12, 2013 Category: Cardiology Authors: Ishii, S., Okamoto, Y., Katsumata, H., Egawa, S., Yamanaka, D., Fukushima, M., Minami, S. Tags: Experimental Studies Source Type: research

Systemic Vascular Hemodynamic Changes due to 17-{beta}-Estradiol Intranasal Administration
Conclusions: The administration of a single intranasal dose of 17-β-estradiol in healthy postmenopausal women increased cerebral perfusions, whereas the effect on peripheral circulation was much more limited. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 12, 2013 Category: Cardiology Authors: Ciccone, M. M., Scicchitano, P., Gesualdo, M., Fornarelli, F., Pinto, V., Farinola, G., Lagioia, R., Sassara, M., Zito, A., Federici, A., Cicinelli, E. Tags: Clinical Studies Source Type: research

Comparison of Bumetanide- and Metolazone-Based Diuretic Regimens to Furosemide in Acute Heart Failure
Conclusion: Compared to CIF, F + M or CIB was associated with greater increases in UO. No difference in the incidence of worsening renal function was found; however, electrolyte abnormalities may be more prevalent when furosemide is combined with metolazone or when bumetanide is used. These therapeutic differences warrant prospective study. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 12, 2013 Category: Cardiology Authors: Ng, T. M. H., Konopka, E., Hyderi, A. F., Hshieh, S., Tsuji, Y., Kim, B. J., Han, S. Y., Phan, D. H., Jeng, A. I., Lou, M., Elkayam, U. Tags: Clinical Studies Source Type: research

Ivabradine in Combination With Metoprolol Succinate in the Treatment of Inappropriate Sinus Tachycardia
Conclusion: Combining ivabradine with metoprolol is an effective and well-tolerated treatment option for IST in patients with refractory to monotherapy. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 12, 2013 Category: Cardiology Authors: Ptaszynski, P., Kaczmarek, K., Ruta, J., Klingenheben, T., Cygankiewicz, I., Wranicz, J. K. Tags: Clinical Studies Source Type: research

The Effect of Continuous Infusion Loop Diuretics in Patients With Acute Decompensated Heart Failure With Hypoalbuminemia
Conclusion: Overall, hypoalbuminemia did not decrease the diuretic effectiveness when measured by the net urine output in patients receiving continuous infusion diuretics for the treatment of ADHF. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 12, 2013 Category: Cardiology Authors: Bleske, B. E., Clark, M. M., Wu, A. H., Dorsch, M. P. Tags: Clinical Studies Source Type: research

Effect of a Single High Loading Dose of Rosuvastatin on Percutaneous Coronary Intervention for Acute Coronary Syndromes
Conclusions: A single, high dose (20 mg) of rosuvastatin prior to PCI reduces postprocedural myocardial injury in patients with ACS, with a concomitant attenuation of the postprocedural increase in hs-CRP and IL-6 levels. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 12, 2013 Category: Cardiology Authors: Wang, Z., Dai, H., Xing, M., Yu, Z., Lin, X., Wang, S., Zhang, J., Hou, F., Ma, Y., Ren, Y., Tan, K., Wang, Y., Ge, Z. Tags: Clinical Studies Source Type: research

Effects of Statins on Serum n-3 to n-6 Polyunsaturated Fatty Acid Ratios in Patients With Coronary Artery Disease
Conclusions: Pitavastatin decreased the serum DHA/AA ratio, whereas pravastatin had no effect on this ratio. Neither pitavastatin nor pravastatin had an effect on the serum EPA/AA ratio in patients with coronary artery disease. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 12, 2013 Category: Cardiology Authors: Nozue, T., Yamamoto, S., Tohyama, S., Fukui, K., Umezawa, S., Onishi, Y., Kunishima, T., Sato, A., Nozato, T., Miyake, S., Takeyama, Y., Morino, Y., Yamauchi, T., Muramatsu, T., Hibi, K., Michishita, I. Tags: Clinical Studies Source Type: research

{beta}-Adrenergic Blockade in Cardiovascular Disease
The development and subsequent clinical application of the β-adrenergic receptor blocking drugs represent one of the major advances in human pharmacotherapeutics. No other class of synthetic drugs has demonstrated such widespread therapeutic utility for the treatment and prevention of so many cardiovascular diseases. In addition, these drugs have proven to be molecular probes that have contributed to our understanding of the disease, and on the molecular level, both the structure and function of the 7 transmembrane G protein receptors that mediate the actions of many different hormones, neurotransmitters, and drugs. T...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 12, 2013 Category: Cardiology Authors: Frishman, W. H. Tags: Review Article Source Type: research

Editor's Note
(Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 12, 2013 Category: Cardiology Authors: Kloner, R. A. Tags: Editorial Source Type: research