A Model of Hypoxia-Reoxygenation on Isolated Adult Mouse Cardiomyocytes: Characterization, Comparison With Ischemia-Reperfusion, and Application to the Cardioprotective Effect of Regular Treadmill Exercise

In conclusion, this H/R model of cardiomyocytes freshly isolated from adult mice shows similar characteristics to the in vivo ischemia-reperfusion conditions. The comparison of in vivo and in vitro settings represents a powerful approach to investigate cardioprotective strategies and to distinguish between direct and indirect cardiomyocyte-dependent mechanisms.

Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 12, 2013 Category: Cardiology Authors: Portal, L., Martin, V., Assaly, R., d'Anglemont de Tassigny, A., Michineau, S., Berdeaux, A., Ghaleh, B., Pons, S. Tags: Experimental Studies Source Type: research