Comparison of Bumetanide- and Metolazone-Based Diuretic Regimens to Furosemide in Acute Heart Failure

Conclusion:
Compared to CIF, F + M or CIB was associated with greater increases in UO. No difference in the incidence of worsening renal function was found; however, electrolyte abnormalities may be more prevalent when furosemide is combined with metolazone or when bumetanide is used. These therapeutic differences warrant prospective study.

Source: Journal of Cardiovascular Pharmacology and Therapeutics - June 12, 2013 Category: Cardiology Authors: Ng, T. M. H., Konopka, E., Hyderi, A. F., Hshieh, S., Tsuji, Y., Kim, B. J., Han, S. Y., Phan, D. H., Jeng, A. I., Lou, M., Elkayam, U. Tags: Clinical Studies Source Type: research