{beta}3-Adrenoceptor Impairs Mitochondrial Biogenesis and Energy Metabolism During Rapid Atrial Pacing-Induced Atrial Fibrillation

Conclusion:
The activation of β3-AR contributes to atrial metabolic remodeling via transcriptional downregulation of PGC-1α/NRF-1/Tfam pathway that are involved in mitochondrial biogenesis, which ultimately perturbs mitochondrial function in rapid pacing-induced AF. The β3-AR is therefore a potential novel therapeutic target for the treatment or prevention of AF.

Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 10, 2015 Category: Cardiology Authors: Dong, J., Zhao, J., Zhang, M., Liu, G., Wang, X., Liu, Y., Yang, N., Liu, Y., Zhao, G., Sun, J., Tian, J., Cheng, C., Wei, L., Li, Y., Li, W. Tags: Experimental Studies Source Type: research